“A COMPREHENSIVE REVIEW ON THE ACIDITY SUPPRESSING EFFECT BY USING PEPPERMINT LEAVES AND ALMOND FRUIT”
Main Article Content
Keywords
Peppermint, Raw Almonds, Acidity, GERD, Gastrointestinal Health, Phytochemicals, Anti-inflammatory, Antioxidant
Abstract
This review explores the acidity-suppressing effects of peppermint (Mentha piperita L.) and raw almonds (Prunus dulcis). Peppermint, with its rich phytochemical profile, exhibits significant anti-inflammatory, antimicrobial, and antispasmodic properties, which can alleviate gastrointestinal discomfort and reduce acidity. Its active components, such as menthol and menthone, play a crucial role in relaxing the esophageal sphincter, reducing intracolonic pressure, and minimizing the symptoms of gastrointestinal disorders like GERD (Gastroesophageal Reflux Disease). Raw almonds, known for their high content of bioactive compounds such as flavonoids and phenolic acids, also demonstrate anti-inflammatory and antioxidant activities that contribute to their acid-neutralizing properties. The review highlights the potential of these natural remedies in managing acidity and promoting digestive health, emphasizing the need for further clinical studies to validate these effects.
References
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27. Sachan AK, Das DR, Shuaib MD, Gangwar SS, Sharma R. An overview on menthae piperitae (peppermint oil). Int J Pharmaceut Chem Biol Sci. 2013 Jul 1;3:834-8
28. Shams R, Oldfield EC, Copare J, Johnson DA. Peppermint oil: clinical uses in the treatment of gastrointestinal diseases. JSM Gastroenterol Hepatol. 2015;3(1):1035.
29. Hussain SZ, Naseer B, Qadri T, Fatima T, Bhat TA. Almond (Prunus dulcis)—morphology, taxonomy, composition and health benefits. Infruits Grown in Highland Regions of the Himalayas: Nutritional and Health Benefits 2021 Jun 16 (pp. 283-295). Cham: Springer International Publishing.
30. Mushtaq A, Khaliq M, Saeed A, Azeem MW, Ghania JB. Almond (Purunus amygdalus L.): A review on health benefits, nutritional value and therapeutic applications. Int. J. Chem. Biochem. Sci. 2015;8:103-6.
31. Syed Zameer Hussain · Bazila Naseer · Tahiya Qadri · Tabasum Fatima · Tashooq Ahmad Bhat. Fruits Grown in Highland Regions of the Himalayas. Nutritional and Health Benefits. ISBN 978-3-030-75501-0 ISBN 978-3-030-75502-7.
32. Singh D, Gohil KJ, Rajput RT, Sharma V. Almond (Prunus amygdalus Batsch.): a latest review on pharmacology and medicinal uses. Research Journal of Pharmacy and Technology. 2022;15(7):3301-8
33. Masihuzzaman AM, Iftikhar MY, Farheen K. Badam shireen (Prunus dulcis Mill): A ghiza-e-dawaee and immunomodulator: A latest review. International Journal of Unani and Integrative Medicine. 2020;4(2):09-14.
34. Pedro Martínez-Gómez1, Raquel Sánchez-Pérez1, Federico Dicenta1, Werner Howad2, Pere Arús2, and Thomas M. Gradziel3. Almond chapter-11. Researchgate .2014.
35. Naveen Gautam. Prnus dulcis(Mill.)D.A Webb. Accession No. CPUH 10587. Career point university Hamirpur. 2020.
36. Almond | Diseases and Pests, Description, Uses, Propagation. Plant village.
37. Petruzzello, Melissa. "almond". Encyclopedia Britannica, 21 Jul. 2024,
38. Anonymous, ”Almond” Wikipedia .
39. Prgomet I, Gonçalves B, Domínguez-Perles R, Pascual-Seva N, Barros AI. Valorization challenges to almond residues: Phytochemical composition and functional application. Molecules. 2017 Oct 20;22(10):1774.
40. Pasqualone A, Laddomada B, Boukid F, Angelis DD, Summo C. Use of almond skins to improve nutritional and functional properties of biscuits: An example of upcycling. Foods. 2020 Nov 20;9(11):1705.
41. Li X, Liu Y, Hao J, Wang W. Study of almond shell characteristics. Materials. 2018 Sep 19;11(9):1782
42. Depeters EJ, Swanson KL, Bill HM, Asmus J, Heguy JM. Nutritional composition of almond hulls. Applied animal science. 2020 Dec 1;36(6):761-70
43. Sindhu Shivaram. “Almond Oil: Give your skin that extra nourishment & glow it deserves”. Enclaire, Jan 17 2022,
44. Rajaram S, Connell KM, Sabaté J. Effect of almond-enriched high-monounsaturated fat diet on selected markers of inflammation: a randomised, controlled, crossover study. British journal of nutrition. 2010 Mar;103(6):907-12.
45. Arangia A, Ragno A, Cordaro M, D’Amico R, Siracusa R, Fusco R, Marino Merlo F, Smeriglio A, Impellizzeri D, Cuzzocrea S, Mandalari G. Antioxidant Activity of a Sicilian Almond Skin Extract Using In Vitro and In Vivo Models. International Journal of Molecular Sciences. 2023 Jul 28;24(15):12115.
46. Jabeen A, Baig MT, Shaikh S, Sarosh NA, Kashif SS, Shahnaz S, Vengus P, Soomro H, Shahid U. In vivo study on laxative effect of Prunus amygdalus oil. International Journal of Medical Research & Health Sciences. 2019;8(3):121-5.
47. Singar S, Kadyan S, Patoine C, Park G, Arjmandi B, Nagpal R. The Effects of Almond Consumption on Cardiovascular Health and Gut Microbiome: A Comprehensive Review. Nutrients. 2024 Jun 20;16(12):1964.
48. Musarra-Pizzo M, Ginestra G, Smeriglio A, Pennisi R, Sciortino MT, Mandalari G. The antimicrobial and antiviral activity of polyphenols from almond (Prunus dulcis L.) Skin. Nutrients. 2019 Oct 3;11(10):2355.
49. Abdullah MK, Hussain MK. Badam (Prunus amygdalus Bail.): A fruit with medicinal properties. International Journal of Herbal Medicine. 2017;5(5):114-7.
50. Kleeberg, J . Studies on Almonds in Ulcer Therapy. Gastroenterologin 1956.
2. VAN DE GRAAFF KM. Anatomy and physiology of the gastrointestinal tract. The Pediatric Infectious Disease Journal. 1986 Jan 1; 5(1):11-6.
3. Ravisankar P, Koushik O, Reddy A, kumaru AP, Pragna P. A detailed analysis on acidity and ulcers in esophagus, gastric and duodenal ulcers and management. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 2016;15(1):94-114.
4. Yamamura R, Inoue KY, Nishino K, Yamasaki S. Intestinal and fecal ph in human health. Frontiers in Micro biomes. 2023 Jul 26;2:1192316.
5. Bereda G. Peptic Ulcer disease: definition, pathophysiology, and treatment. Journal of Biomedical and Biological Sciences. 2022;1(2):1-0.
6. Ahmad RS, Imran A, Arshad MS, Hussain MB, Waheed M, Safdar S, Yasmin Z. Introductory chapter: Mentha piperita (a valuable herb): Brief overview. Herbs and Spices. 2020 Oct 7;25(4):275-81.
7. Rita P, Animesh DK. An updated overview on peppermint (Mentha piperita L.). International Research Journal of Pharmacy. 2011 Aug;2(8):1-0.
8. Mentha piperata - Herb Information Himalaya Wellness Company
9. Naveen KL, Bhattacharjee A, Hegde K, Shabarayanbsp A. A Detailed Review on Pharmacological Profile of Mentha piperita. RGUHS Journal of Pharmaceutical Sciences. 2020;10(1).
10. Singh R, Shushni MA, Belkheir A. Antibacterial and antioxidant activities of Mentha piperita L. Arabian Journal of Chemistry. 2015 May 1;8(3):322-8.
11. Mint -nhb.gov- Horticultural College and Research Institute, Tamil Nadu Agricultural University, Coimbatore – 641 003 [Tel: (0422) 244 5414].
12. Dr Manoj Semwal Principal Scientist CSIR-CIMAP. From importing menthol mint to becoming a leading exporter. Council of Scientific & Industrial Research.
13. Fayed MA. Mentha Piperita L.-A promising dental care herb mainly against cariogenic bacteria. Universal Journal of Pharmaceutical Research. 2019 Jul 9.
14. Nayak P, Kumar T, Gupta AK, Joshi NU. Peppermint a medicinal herb and treasure of health: A review. Journal of Pharmacognosy and Phytochemistry. 2020; 9(3):1519-28.
15. Jyoti Bashyal Peppermint (Mentha piperita): Aromatic Herb. Botany in Science info 2024.
16. Eftekhari A, Khusro A, Ahmadian E, Dizaj SM, Hasanzadeh A, Cucchiarini M. Phytochemical and nutra-pharmaceutical attributes of Mentha spp.: A comprehensive review. Arabian Journal of Chemistry. 2021 May 1; 14(5):103106.
17. Sharma M, Gautam D. Phytoconstituents and medicinal value of Mentha piperita. Modern Phytomorphology. 2022 Feb 28;15:156-60.
18. Mahendran G, Rahman LU. Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha× piperita L.)—A review. Phytotherapy Research. 2020 Sep;34(9):2088-139.
19. Hudz N, Kobylinska L, Pokajewicz K, Horčinová Sedláčková V, Fedin R, Voloshyn M, Myskiv I, Brindza J, Wieczorek PP, Lipok J. Mentha piperita: essential oil and extracts, their biological activities, and perspectives on the development of new medicinal and cosmetic products. Molecules. 2023 Nov 6;28(21):7444.
20. Desam NR, Al-Rajab AJ, Sharma M, Mylabathula MM, Gowkanapalli RR, Albratty M. Chemical constituents, in vitro antibacterial and antifungal activity of Mentha× Piperita L.(peppermint) essential oils. Journal of King Saud University-Science. 2019 Oct 1;31(4):528-33.
21. Tyagi AK, Malik A. Antimicrobial potential and chemical composition of Mentha piperita oil in liquid and vapour phase against food spoiling microorganisms. Food control. 2011 Nov 1;22(11):1707-14.
22. Heimes K, Hauk F, Verspohl EJ. Mode of action of peppermint oil and (‐)‐menthol with respect to 5‐HT3 receptor subtypes: binding studies, cation uptake by receptor channels and contraction of isolated rat ileum. Phytotherapy Research. 2011 May;25(5):702-8.
23. Schmidt E, Bail S, Buchbauer G, Stoilova I, Atanasova T, Stoyanova A, Krastanov A, Jirovetz L. Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha x piperita. Natural product communications. 2009 Aug;4(8):1934578X0900400819.
24. Arakawa T, Shibata M, Hosomi K, Watanabe T, Honma Y, Kawasumi K, Takeuchi Y. Anti-allergic effects of peppermint oil, chicle and jelutong. Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi). 1992 Dec 5;33(6):569-75_1.
25. Paula Gardiner Peppermint Longwood Herbal Task Force: http://www.mcp.edu/herbal/ Revised May 2, 2000
26. Loolaie M, Moasefi N, Rasouli H, Adibi H. Peppermint and its functionality: A review. Arch Clin Microbiol. 2017 Jul;8(4):54.
27. Sachan AK, Das DR, Shuaib MD, Gangwar SS, Sharma R. An overview on menthae piperitae (peppermint oil). Int J Pharmaceut Chem Biol Sci. 2013 Jul 1;3:834-8
28. Shams R, Oldfield EC, Copare J, Johnson DA. Peppermint oil: clinical uses in the treatment of gastrointestinal diseases. JSM Gastroenterol Hepatol. 2015;3(1):1035.
29. Hussain SZ, Naseer B, Qadri T, Fatima T, Bhat TA. Almond (Prunus dulcis)—morphology, taxonomy, composition and health benefits. Infruits Grown in Highland Regions of the Himalayas: Nutritional and Health Benefits 2021 Jun 16 (pp. 283-295). Cham: Springer International Publishing.
30. Mushtaq A, Khaliq M, Saeed A, Azeem MW, Ghania JB. Almond (Purunus amygdalus L.): A review on health benefits, nutritional value and therapeutic applications. Int. J. Chem. Biochem. Sci. 2015;8:103-6.
31. Syed Zameer Hussain · Bazila Naseer · Tahiya Qadri · Tabasum Fatima · Tashooq Ahmad Bhat. Fruits Grown in Highland Regions of the Himalayas. Nutritional and Health Benefits. ISBN 978-3-030-75501-0 ISBN 978-3-030-75502-7.
32. Singh D, Gohil KJ, Rajput RT, Sharma V. Almond (Prunus amygdalus Batsch.): a latest review on pharmacology and medicinal uses. Research Journal of Pharmacy and Technology. 2022;15(7):3301-8
33. Masihuzzaman AM, Iftikhar MY, Farheen K. Badam shireen (Prunus dulcis Mill): A ghiza-e-dawaee and immunomodulator: A latest review. International Journal of Unani and Integrative Medicine. 2020;4(2):09-14.
34. Pedro Martínez-Gómez1, Raquel Sánchez-Pérez1, Federico Dicenta1, Werner Howad2, Pere Arús2, and Thomas M. Gradziel3. Almond chapter-11. Researchgate .2014.
35. Naveen Gautam. Prnus dulcis(Mill.)D.A Webb. Accession No. CPUH 10587. Career point university Hamirpur. 2020.
36. Almond | Diseases and Pests, Description, Uses, Propagation. Plant village.
37. Petruzzello, Melissa. "almond". Encyclopedia Britannica, 21 Jul. 2024,
38. Anonymous, ”Almond” Wikipedia .
39. Prgomet I, Gonçalves B, Domínguez-Perles R, Pascual-Seva N, Barros AI. Valorization challenges to almond residues: Phytochemical composition and functional application. Molecules. 2017 Oct 20;22(10):1774.
40. Pasqualone A, Laddomada B, Boukid F, Angelis DD, Summo C. Use of almond skins to improve nutritional and functional properties of biscuits: An example of upcycling. Foods. 2020 Nov 20;9(11):1705.
41. Li X, Liu Y, Hao J, Wang W. Study of almond shell characteristics. Materials. 2018 Sep 19;11(9):1782
42. Depeters EJ, Swanson KL, Bill HM, Asmus J, Heguy JM. Nutritional composition of almond hulls. Applied animal science. 2020 Dec 1;36(6):761-70
43. Sindhu Shivaram. “Almond Oil: Give your skin that extra nourishment & glow it deserves”. Enclaire, Jan 17 2022,
44. Rajaram S, Connell KM, Sabaté J. Effect of almond-enriched high-monounsaturated fat diet on selected markers of inflammation: a randomised, controlled, crossover study. British journal of nutrition. 2010 Mar;103(6):907-12.
45. Arangia A, Ragno A, Cordaro M, D’Amico R, Siracusa R, Fusco R, Marino Merlo F, Smeriglio A, Impellizzeri D, Cuzzocrea S, Mandalari G. Antioxidant Activity of a Sicilian Almond Skin Extract Using In Vitro and In Vivo Models. International Journal of Molecular Sciences. 2023 Jul 28;24(15):12115.
46. Jabeen A, Baig MT, Shaikh S, Sarosh NA, Kashif SS, Shahnaz S, Vengus P, Soomro H, Shahid U. In vivo study on laxative effect of Prunus amygdalus oil. International Journal of Medical Research & Health Sciences. 2019;8(3):121-5.
47. Singar S, Kadyan S, Patoine C, Park G, Arjmandi B, Nagpal R. The Effects of Almond Consumption on Cardiovascular Health and Gut Microbiome: A Comprehensive Review. Nutrients. 2024 Jun 20;16(12):1964.
48. Musarra-Pizzo M, Ginestra G, Smeriglio A, Pennisi R, Sciortino MT, Mandalari G. The antimicrobial and antiviral activity of polyphenols from almond (Prunus dulcis L.) Skin. Nutrients. 2019 Oct 3;11(10):2355.
49. Abdullah MK, Hussain MK. Badam (Prunus amygdalus Bail.): A fruit with medicinal properties. International Journal of Herbal Medicine. 2017;5(5):114-7.
50. Kleeberg, J . Studies on Almonds in Ulcer Therapy. Gastroenterologin 1956.
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Dec 11, 2024
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Srivenugopal Iyer. R, Kuntupalli Sandhya Rani, & Dr. Pragnesh Patani. (2024). “A COMPREHENSIVE REVIEW ON THE ACIDITY SUPPRESSING EFFECT BY USING PEPPERMINT LEAVES AND ALMOND FRUIT”. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 953-964. https://doi.org/10.53555/sk7txp12
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Author Biographies
Srivenugopal Iyer. R
Student, Khyati College of Pharmacy, Palodia, Ahmedabad.
Kuntupalli Sandhya Rani
Assistant Professor, Khyati College of Pharmacy, Palodia, Ahmedabad
Dr. Pragnesh Patani
Principal and Professor, Khyati College of Pharmacy, Palodia, Ahmedabad
How to Cite
Srivenugopal Iyer. R, Kuntupalli Sandhya Rani, & Dr. Pragnesh Patani. (2024). “A COMPREHENSIVE REVIEW ON THE ACIDITY SUPPRESSING EFFECT BY USING PEPPERMINT LEAVES AND ALMOND FRUIT”. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 953-964. https://doi.org/10.53555/sk7txp12