A REVIEW ON SYNERGISTIC EFFECTS OF PUMPKIN SEEDS AND GUAVA ON HUMAN HEALTH
Main Article Content
Keywords
Pumpkin seed, Guava, Anti-oxidant, Anti-diabetic, Protein, Vitamin
Abstract
This review examines the nutritional and pharmacological benefits of pumpkin and guava, and their potential synergistic effects when combined. Pumpkin seeds exhibit anti-carcinogenic, anti-diabetic, anti-inflammatory, and anti-depressant properties. Guava, on the other hand, is rich in antioxidants, demonstrates anti-cancer activity, and supports immune function and wound healing. The combination of pumpkin and guava may enhance health outcomes through improved antioxidant defense, metabolic regulation, and overall well-being. Marketed formulations and emerging research highlight the promise of these natural pairings in developing new nutraceutical products and functional foods. Further research is warranted to validate these potential benefits and fully explore the health benefits of combining pumpkin and guava.
References
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11. Ruwanthika KH, Munasinghe MM, Marapana RU. “Overview of Cucurbita spp.(pumpkin) and development of value-added products emphasizing its nutritional and chemical composition”. World Journal of Advanced Research and Reviews; 2023;18(2):1215-1226.
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14. Dar AH, Sofi SA, Rafiq S. “Pumpkin the functional and therapeutic ingredient: A review”, International Journal of Food Science and Nutrition; 2017;2(6):165-170.
15. Chaturvedi M, Chaturvedi N, “Potential Pharmacological Activities of Pumpkin Seeds as a Functional Food: A Comprehensive Review”, Journal of Ayurvedic and Herbal Medicine; 2023; 9(2): 101-107.
16. Chen X, Qian L, Wang B, Zhang Z, Liu H, Zhang Y, Liu J. “Synergistic hypoglycemic effects of pumpkin polysaccharides and puerarin on type II diabetes mellitus mice”, Molecules. 2019;24(5):955.
17. Li T, Ito A, Chen X, Long C, Okamoto M, Raoul F, Giraudoux P, Yanagida T, Nakao M, Sako Y, Xiao N. Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China. Acta tropica; 2012;124(2):152-157.
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19. Shalan NA, Rahim NA, Saad N. “The effects of Black Mulberry fruit extract, sunflower seed, and pumpkin seed with exercise on memory function and neural activation biomarkers among healthy young adults”, Current Research in Nutrition and Food Science Journal; 2020;8(1):281-290.
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21. Singh SK, Malhotra SK, Bhargava R, Singh RS, Shukla AK. “Morphological and physiological characterization of guava (Psidium guajava) under hot-arid zone of Rajasthan”, Indian Journal of Agricultural Sciences; 2017;87(4):491-495.
22. Parvez GM, Shakib U, Khokon M, Sanzia M, “A short review on a nutritional fruit: guava,” Toxicology and Research; 2018;1:1-8.
23. Hussain SZ, Naseer B, Qadri T, Fatima T, Bhat TA, “ Guava (Psidium Guajava)-Morphology, Taxonomy, Composition, and Health Benefits,” InFruits Grown in Highland Regions of the Himalayas: Nutritional and Health Benefits; 2021; 257-267.
24. Kafle A, Mohapatra SS, Reddy I, Chapagain M. “A review on medicinal properties of Psidium guajava”, J Med Plants Stud; 2018;6(4):44-47.
25. Angulo-López JE, Flores-Gallegos AC, Torres-León C, Ramírez-Guzmán KN, Martínez GA, Aguilar CN. “Guava (Psidium guajava L.) fruit and valorization of industrialization by-products”, Processes. 2021;9(6):2-17.
26. Naseer S, Hussain S, Naeem N, Pervaiz M, Rahman M. “The phytochemistry and medicinal value of Psidium guajava (guava)”, Clinical phytoscience; 2018;4(1):1-8.
27. Amjad M, Khan AR, Ahmed A, Luqman M, Raza A, Hussain I. “A review on the Beneficial Properties od Guava Plant”, Annals Of Plant Science;2021;10(12):4450-4456.
28. Sravani S, Charitha sai CH, Nadendla RR. “A Complete Review On Psidium Guajava Linn(Medicinal Plant)”, International Journal Of Pharmaceutical Sciences Review and Reasearch; 2021;67(2):13-17.
29. Gavhane A, Chopade S, Dighe P, Kour A. “The nutritional and bioactive potential of guava and possibilities for its commercial application in value-added products”, Pharma Innov. J; 2022;11:2643-2647.
30. Tanmoy S. “Growth and yield attributes of guava (Psidium guajava L.) varieties under West Bengal condition”, International Journal of Agriculture Sciences, ISSN; 2016:3499-3501.
31. Liu H, Wei S, Shi L, Tan H. “Preparation, structural characterization and bioactivity of polysaccharides from Psidium guajava”, Food Chemistry; 2023;411:135423.
32. Kumari N, Gautam S, Ashutosh C. “Psidium Guajava A fruit or medicine-An overview”, The Pharma Innovation; 2013;2(8, Part A):63-67.
33. Rajpoot D, Sanodiya M, Mishra P, Kumari. “P.Guava(psidium guajava) Morphology and Taxonomy,Uses and Composition” Just Agriculture; 2024;4(8):138-143.
34. Kareem AT, Kadhim EJ. “Psidium guajava: A Review on Its Pharmacological and Phytochemical Constituents”, Biomedical & Pharmacology Journal; 2024;17(2):1079-1090.
35. Asif F, Khan MKI, Asif M, Tehreem Z, Tehreem S. “Nutritional and Therapeutical Properties of Guava(Psidium guajava) and its Applications: A Review”, Plant Science Journal; 2022;11(1):07-16.
36. Kumar R, Kumar A, Gautam S. “Guava: A Healthy Fruit With Therapeutic Benefits”, New Era Agriculture Magazine; 2023;1(8):20-23.
37. Mathpal D, Rathore G. “An Analysis of Health Benefits of Guava”, International Journal of Innovative Research in Engineering & Management; 2022;9(1):239-242.
38. Lakshmi EN, Kumar S, Sudhir DA, Jitendrabhai PS, Singh S, Jangir S. “A review on nutritional and medicinal properties of guava (Psidium guajavaL.)”, Annals of Phytomedicine; 2022;11(2):240-244.
39. Mitra S, Hodiwala AV, Kar H. “Susceptibility and Synergistic Effects of Guava Plant Extract and Antimicrobial Drugs on Escherichia coli”, Cureus; 2024;16(1):2-8.
40. Amadi LO, Wanabia D, Amadi V. “Synergistic effects of alum and guava (Psidium guajava) leaf extracts on some pathogens from clinical samples”, International Journal of Current Research; 2016;8(05):31354-31358.
41. Jyoti A, Agarwal M, Tomar RS. “Synergistic effect of Zinc Oxide Nanoparticles and Guava Leaf extract for Enhanced antimicrobial activity against Enterotoxigenic Escherichia coli”, Journal of Biochemical Technology; 2020;11(2-2020):17-23.
42. Mounica M, Lakshmi GT, Manaswini K, Tony DE, Babu AN. “Synergistic Effect of Leaf Extracts of Ficus hispida and Psidium guajava for Anti-Diabetic Activity on Wistar Rats”, Research Journal of Pharmacy and Technology; 2020;13(6):2877-2880.
43. Bala I, Yusha'u M, Lawal D, Abubakar S. “Synergistic Effect of Eucalyptus (Eucalyptus Camaldulensis) and Guava (Psidium Guajava) Ethanolic Extracts on Eschericia Coli and Staphylococcus Aureus”, Academic Research International; 2014;5(6):35-41.
2. Dotto JM, Chacha JS, “The potential of pumpkin seeds as a functional food ingredient: A review,” Scientific African; 2020;1;1-14.
3. Singh A, Kumar V, “Pumpkin seeds as a nutraceutical and functional food ingredient for future: A review,” Grain & Oil Science and Technology; 2023;7(1);12-29.
4. Syed QA, Akram M, Shukat R. “Nutritional and therapeutic importance of the pumpkin seeds. Seed”, Biomedical Journal of Scientific & Technical Research; 2019;21(2):15798-15803.
5. Hussain A, Kausar T, Sehar S, Sarwar A, Quddoos MY, Aslam J, Liaqat A, Siddique T, An QU, Kauser S, Rehman A. “A review on biochemical constituents of pumpkin and their role as pharma foods; a key strategy to improve health in post COVID 19 period”, Food Production, Processing and Nutrition; 2023; 22;5(1):2-14.
6. Dhiman AK, Sharma KD, Attri S. “Functional constitutents and processing of pumpkin: A review ”, Journal of Food Science and Technology; 2009;46(5):411-417.
7. Rasdi MR, Abidin MZ, Malik NH. “Effect of Drying Conditions on Functional Properties of Pumpkin Powder”, Advances in Agricultural and Food Research Journal; 2024; ;5(1):2-11.
8. Ahmad G, Khan AA. “Pumpkin: horticultural importance and its roles in various forms; a review Int”, J. Hortic. Agric; 2019;4(1):1-6.
9. Lemus-Mondaca R, Marin J, Rivas J, Sanhueza L, Soto Y, Vera N, Puente-Díaz L. “Semillas de calabaza (Cucurbita máxima). Una revisión de sus propiedades funcionales y sub-productos”, Revista chilena de nutrición; 2019;46(6):1-9.
10. Swami, K.R.M. “Origin, Distribution, Taxonomy, Botanical Description, Genatics, Genatic Diversity, And Breeding Of Pumpkins And Squashes (Cucurbita spp.)”, International Journal of Current Research; 2022; 12(11): 22860-22877.
11. Ruwanthika KH, Munasinghe MM, Marapana RU. “Overview of Cucurbita spp.(pumpkin) and development of value-added products emphasizing its nutritional and chemical composition”. World Journal of Advanced Research and Reviews; 2023;18(2):1215-1226.
12. Yadav M, Jain S, Tomar R, Prasad GB, Yadav H. “Medicinal and biological potential of pumpkin: an updated review”, Nutrition research reviews. 2010; 23(2):184-190.
13. Batool M, Ranjha MM, Roobab U, Manzoor MF, Farooq U, Nadeem HR, Nadeem M, Kanwal R, AbdElgawad H, Al Jaouni SK, Selim S. “Nutritional value, phytochemical potential, and therapeutic benefits of pumpkin (Cucurbita sp.)”, Plants; 2022;11(11):2-23.
14. Dar AH, Sofi SA, Rafiq S. “Pumpkin the functional and therapeutic ingredient: A review”, International Journal of Food Science and Nutrition; 2017;2(6):165-170.
15. Chaturvedi M, Chaturvedi N, “Potential Pharmacological Activities of Pumpkin Seeds as a Functional Food: A Comprehensive Review”, Journal of Ayurvedic and Herbal Medicine; 2023; 9(2): 101-107.
16. Chen X, Qian L, Wang B, Zhang Z, Liu H, Zhang Y, Liu J. “Synergistic hypoglycemic effects of pumpkin polysaccharides and puerarin on type II diabetes mellitus mice”, Molecules. 2019;24(5):955.
17. Li T, Ito A, Chen X, Long C, Okamoto M, Raoul F, Giraudoux P, Yanagida T, Nakao M, Sako Y, Xiao N. Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China. Acta tropica; 2012;124(2):152-157.
18. Park HJ, Kim JY, Kim HS, Lee SH, Jang JS, Lee MH. “Synergistic effect of fruit–seed mixed juice on inhibition of angiotensin I-converting enzyme and activation of NO production in EA. hy926 cells”, Food science and biotechnology; 2019;28(3):881-893.
19. Shalan NA, Rahim NA, Saad N. “The effects of Black Mulberry fruit extract, sunflower seed, and pumpkin seed with exercise on memory function and neural activation biomarkers among healthy young adults”, Current Research in Nutrition and Food Science Journal; 2020;8(1):281-290.
20. Arzoo SH, Chattopadhyay K, Banerjee S, Chattopadhyay B. “Synergistic improved efficacy of Gymnadenia orchidis root Salep and pumpkin seed on induced diabetic complications”, diabetes research and clinical practice; 2018;146:278-288.
21. Singh SK, Malhotra SK, Bhargava R, Singh RS, Shukla AK. “Morphological and physiological characterization of guava (Psidium guajava) under hot-arid zone of Rajasthan”, Indian Journal of Agricultural Sciences; 2017;87(4):491-495.
22. Parvez GM, Shakib U, Khokon M, Sanzia M, “A short review on a nutritional fruit: guava,” Toxicology and Research; 2018;1:1-8.
23. Hussain SZ, Naseer B, Qadri T, Fatima T, Bhat TA, “ Guava (Psidium Guajava)-Morphology, Taxonomy, Composition, and Health Benefits,” InFruits Grown in Highland Regions of the Himalayas: Nutritional and Health Benefits; 2021; 257-267.
24. Kafle A, Mohapatra SS, Reddy I, Chapagain M. “A review on medicinal properties of Psidium guajava”, J Med Plants Stud; 2018;6(4):44-47.
25. Angulo-López JE, Flores-Gallegos AC, Torres-León C, Ramírez-Guzmán KN, Martínez GA, Aguilar CN. “Guava (Psidium guajava L.) fruit and valorization of industrialization by-products”, Processes. 2021;9(6):2-17.
26. Naseer S, Hussain S, Naeem N, Pervaiz M, Rahman M. “The phytochemistry and medicinal value of Psidium guajava (guava)”, Clinical phytoscience; 2018;4(1):1-8.
27. Amjad M, Khan AR, Ahmed A, Luqman M, Raza A, Hussain I. “A review on the Beneficial Properties od Guava Plant”, Annals Of Plant Science;2021;10(12):4450-4456.
28. Sravani S, Charitha sai CH, Nadendla RR. “A Complete Review On Psidium Guajava Linn(Medicinal Plant)”, International Journal Of Pharmaceutical Sciences Review and Reasearch; 2021;67(2):13-17.
29. Gavhane A, Chopade S, Dighe P, Kour A. “The nutritional and bioactive potential of guava and possibilities for its commercial application in value-added products”, Pharma Innov. J; 2022;11:2643-2647.
30. Tanmoy S. “Growth and yield attributes of guava (Psidium guajava L.) varieties under West Bengal condition”, International Journal of Agriculture Sciences, ISSN; 2016:3499-3501.
31. Liu H, Wei S, Shi L, Tan H. “Preparation, structural characterization and bioactivity of polysaccharides from Psidium guajava”, Food Chemistry; 2023;411:135423.
32. Kumari N, Gautam S, Ashutosh C. “Psidium Guajava A fruit or medicine-An overview”, The Pharma Innovation; 2013;2(8, Part A):63-67.
33. Rajpoot D, Sanodiya M, Mishra P, Kumari. “P.Guava(psidium guajava) Morphology and Taxonomy,Uses and Composition” Just Agriculture; 2024;4(8):138-143.
34. Kareem AT, Kadhim EJ. “Psidium guajava: A Review on Its Pharmacological and Phytochemical Constituents”, Biomedical & Pharmacology Journal; 2024;17(2):1079-1090.
35. Asif F, Khan MKI, Asif M, Tehreem Z, Tehreem S. “Nutritional and Therapeutical Properties of Guava(Psidium guajava) and its Applications: A Review”, Plant Science Journal; 2022;11(1):07-16.
36. Kumar R, Kumar A, Gautam S. “Guava: A Healthy Fruit With Therapeutic Benefits”, New Era Agriculture Magazine; 2023;1(8):20-23.
37. Mathpal D, Rathore G. “An Analysis of Health Benefits of Guava”, International Journal of Innovative Research in Engineering & Management; 2022;9(1):239-242.
38. Lakshmi EN, Kumar S, Sudhir DA, Jitendrabhai PS, Singh S, Jangir S. “A review on nutritional and medicinal properties of guava (Psidium guajavaL.)”, Annals of Phytomedicine; 2022;11(2):240-244.
39. Mitra S, Hodiwala AV, Kar H. “Susceptibility and Synergistic Effects of Guava Plant Extract and Antimicrobial Drugs on Escherichia coli”, Cureus; 2024;16(1):2-8.
40. Amadi LO, Wanabia D, Amadi V. “Synergistic effects of alum and guava (Psidium guajava) leaf extracts on some pathogens from clinical samples”, International Journal of Current Research; 2016;8(05):31354-31358.
41. Jyoti A, Agarwal M, Tomar RS. “Synergistic effect of Zinc Oxide Nanoparticles and Guava Leaf extract for Enhanced antimicrobial activity against Enterotoxigenic Escherichia coli”, Journal of Biochemical Technology; 2020;11(2-2020):17-23.
42. Mounica M, Lakshmi GT, Manaswini K, Tony DE, Babu AN. “Synergistic Effect of Leaf Extracts of Ficus hispida and Psidium guajava for Anti-Diabetic Activity on Wistar Rats”, Research Journal of Pharmacy and Technology; 2020;13(6):2877-2880.
43. Bala I, Yusha'u M, Lawal D, Abubakar S. “Synergistic Effect of Eucalyptus (Eucalyptus Camaldulensis) and Guava (Psidium Guajava) Ethanolic Extracts on Eschericia Coli and Staphylococcus Aureus”, Academic Research International; 2014;5(6):35-41.
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Dec 11, 2024
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How to Cite
Heli S Patel, Dr. Nikita Patel, & Dr. Pragnesh Patani. (2024). A REVIEW ON SYNERGISTIC EFFECTS OF PUMPKIN SEEDS AND GUAVA ON HUMAN HEALTH. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 899-907. https://doi.org/10.53555/pd30jd40
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Author Biographies
Heli S Patel
Khyati College of Pharmacy, Palodia, Ahmedabad
Dr. Nikita Patel
Associate Professor, Department of Pharmaceutics, Khyati College of Pharmacy, Palodia, Ahmedabad
Dr. Pragnesh Patani
Principal, Khyati College of Pharmacy, Palodia, Ahmedabad
How to Cite
Heli S Patel, Dr. Nikita Patel, & Dr. Pragnesh Patani. (2024). A REVIEW ON SYNERGISTIC EFFECTS OF PUMPKIN SEEDS AND GUAVA ON HUMAN HEALTH. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 899-907. https://doi.org/10.53555/pd30jd40