ADVANCEMENT AND CHARACTERIZATION OF NUTRACEUTICALS AS PHYSIOLOGICAL BENEFITS AGAINST MULTIPLE PATHOGENS; A COMPREHENSIVE REVIEW
Main Article Content
Keywords
herbal nutraceuticals, Nutrients, Pharmaceuticals, Chronic diseases, Therapeutic Efficacy
Abstract
Nutraceuticals are products, which other than nutrition are also used as medicine. A nutraceutical product may be defined as a substance which has physiological benefit or provides protection against chronic disease. Nutraceuticals may be used to improve health, delay the aging process, prevent chronic diseases, increase life expectancy, or support the structure or function of the body. Nowadays, nutraceuticals have received considerable interest due to potential nutritional, safety and therapeutic effects. Recent studies have shown promising results for these compounds in various complications. In the present review much effort has been devoted to presenting new concepts about nutraceuticals based on their disease modifying indications. Emphasis has been made to present herbal nutraceuticals effective on hard curative disorders related to oxidative stress including allergy, Alzheimer, cardiovascular, cancer, diabetes, eye, immune, inflammatory and Parkinson’s diseases as well as obesity. The recently published papers about different aspects of nutraceuticals as alternative for pharmaceuticals were searched using scientific sites such as Medline, PubMed, and Google Scholar. The used terms included nutraceutical and allergy, Alzheimer, cardiovascular, cancer, diabetes, eye, immune, inflammatory or Parkinson.
Nutraceuticals are items other than sustenance which are additionally utilized as medication.
References
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2. Zhao J. Nutraceuticals, nutritional therapy, phytonutrients, and phytotherapy for improvement of human health: a perspective on plant biotechnology application. Recent patents on biotechnology. 2007;1(1):75-97.
3. Chauhan B, Kumar G, Kalam N, Ansari SH. Current concepts and prospects of herbal nutraceutical: A review. Journal of advanced pharmaceutical technology & research. 2013;4(1):4.
4. Zeisel SH. Regulation of" nutraceuticals". American Association for the Advancement of Science; 1999. p. 1853-5.
5. Hardy G. Nutraceuticals and functional foods: introduction and meaning. Nutrition (Burbank, Los Angeles County, Calif). 2000;16(7-8):688-9.
6. Baradaran A, Madihi Y, Merrikhi A, Rafieian-Kopaei M, Nasri H. Serum lipoprotein (a) in diabetic patients with various renal function not yet on dialysis. 2013.
7. Nasri H. Impact of diabetes mellitus on parathyroid hormone in hemodialysis patients. Journal of Parathyroid Disease. 2013;1(1):9-11.
8. Madihi Y, Merrikhi A, Baradaran A, Rafieian-Kopaei M, Shahinfard N, Ansari R, et al. Impact of Sumac on postprandialhigh-fat oxidative stress. 2013.
9. Setorki M, Rafieian-Kopaei M, Merikhi A, Heidarian E, Shahinfard N, Ansari R, et al. Suppressive impact of anethum graveolens consumption on biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits. International Journal of Preventive Medicine. 2013;4(8):889.
10. Khosravi-Boroujeni H, Mohammadifard N, Sarrafzadegan N, Sajjadi F, Maghroun M, Khosravi A, et al. Potato consumption and cardiovascular disease risk factors among Iranian population. International journal of food sciences and nutrition. 2012;63(8):913-20.
11. Khosravi-Boroujeni H, Sarrafzadegan N, Mohammadifard N, Sajjadi F, Maghroun M, Asgari S, et al. White rice consumption and CVD risk factors among Iranian population. Journal of health, population, and nutrition. 2013;31(2):252.
12. Shirzad H, Burton R, Smart Y, Rafieian‐kopaei M, Shirzad M. Natural Cytotoxicity of NC‐2+ Cells Against the Growth and Metastasis of WEHI‐164 Fibrosarcoma. Scandinavian journal of immunology. 2011;73(2):85-90.
13. Shirzad M, Kordyazdi R, Shahinfard N, Nikokar M. Does Royal jelly affect tumor cells? Journal of HerbMed Pharmacology. 2013;2(2):45-8.
14. Akhlaghi M, Shabanian G, Rafieian-Kopaei M, Parvin N, Saadat M, Akhlaghi M. Citrus aurantium blossom and preoperative anxiety. Revista brasileira de anestesiologia. 2011;61:707-12.
15. Roohafza H, Sarrafzadegan N, Sadeghi M, Rafieian-Kopaei M, Sajjadi F, Khosravi-Boroujeni H. The association between stress levels and food consumption among Iranian population. Archives of Iranian medicine. 2013;16(3):0-.
16. Baradaran A, Nasri H, Nematbakhsh M, Rafieian-Kopaei M. Antioxidant activity and preventive effect of aqueous leaf extract of Aloe Vera on gentamicin-induced nephrotoxicity in male Wistar rats. La clinica terapeutica. 2014;165(1):7-11.
17. Nasri H, Tavakoli M, Ahmadi A, Baradaran A, Nematbakhsh M, Rafieian-Kopaei M. Ameliorative effect of melatonin against contrast media induced renal tubular cell injury. Pakistan journal of medical sciences. 2014;30(2):261.
18. Parsaei P, Karimi M, Asadi SY, Rafieian-Kopaei M. Bioactive components and preventive effect of green tea (Camellia sinensis) extract on post-laparotomy intra-abdominal adhesion in rats. International Journal of Surgery. 2013;11(9):811-5.
19. Kafash-Farkhad N, Asadi-Samani M, Rafieian-Kopaei M. A review on phytochemistry and pharmacological effects of Prangos ferulacea (L.) Lindl. Life Sci J. 2013;10(8s):360-7.
20. Mirhoseini M, Baradaran A, Rafieian-Kopaei M. Medicinal plants, diabetes mellitus and urgent needs. J HerbMed Pharmacol. 2013;2(2):53-4.
21. Akbari F, Karimi A, Shahinfard N. Effect of turnip on glucose and lipid profiles of alloxan-induced diabetic rats. Iranian Journal of Endocrinology and Metabolism. 2013;14(5):492-7.
22. Bahmani M, Saatloo NV, Maghsoudi R, Momtaz H, Saki K, Kazemi-Ghoshchi B, et al. A comparative study on the effect of ethanol extract of wild Scrophularia deserti and streptomycin on Brucellla melitensis. Journal of HerbMed Pharmacology. 2013;2(1):17-20.
23. Karimi A, Moradi M-T, Saeedi M, Asgari S, Rafieian-Kopaei M. Antiviral activity of Quercus persica L.: high efficacy and low toxicity. Advanced biomedical research. 2013;2.
24. Rafieian-Kopaie M. Metformin and renal injury protection. Nickan Research Institute; 2013. p. 91-2.
25. Rafieian-Kopaei M, Baradaran A, Merrikhi A, Nematbakhsh M, Madihi Y, Nasri H. Efficacy of co-administration of garlic extract and metformin for prevention of gentamicin–renal toxicity in wistar rats: A biochemical study. International journal of preventive medicine. 2013;4(3):258.
26. Kiani M-A, Khodadad A, Mohammadi S, Ghayour Mobarhan M, Saeidi M, Jafari SA, et al. Effect of peppermint on pediatrics’ pain under endoscopic examination of the large bowel. J HerbMed Pharmacol. 2013;2(2):41-4.
27. Hosseini-Asl K, Rafieian-Kopaei M. Can patients with active duodenal ulcer fast Ramadan? Official journal of the American College of Gastroenterology| ACG. 2002;97(9):2471-2.
28. Abdel-Daim MM, El-Tawil OS, Bungau SG, Atanasov AG. Applications of antioxidants in metabolic disorders and degenerative diseases: Mechanistic approach. Hindawi; 2019.
29. Williams RJ, Mohanakumar K, Beart PM. Neuro-nutraceuticals: Further insights into their promise for brain health. Elsevier; 2016. p. 1-3.
30. Van Der Burg KP, Cribb L, Firth J, Karmacoska D, Sarris J. Nutrient and genetic biomarkers of nutraceutical treatment response in mood and psychotic disorders: a systematic review. Nutritional Neuroscience. 2021;24(4):279-95.
31. Helal NA, Eassa HA, Amer AM, Eltokhy MA, Edafiogho I, Nounou MI. Nutraceuticals’ novel formulations: the good, the bad, the unknown and patents involved. Recent patents on drug delivery & formulation. 2019;13(2):105-56.
32. Chong LK, Udell LJ, Downs BW. Intellectual property, branding, trademark and regulatory approvals in nutraceuticals and functional foods. Nutraceutical and Functional Food Regulations in the United States and Around the World: Elsevier; 2008. p. 403-16.
33. DeFelice SL. The nutraceutical revolution: its impact on food industry R&D. Trends in Food Science & Technology. 1995;6(2):59-61.
34. Jack DB. Keep takingthe tomatoes—the exciting world of nutraceuticals. Molecular Medicine Today. 1995;1(3):118-21.
35. Brower V. Nutraceuticals: poised for a healthy slice of the healthcare market? Nature biotechnology. 1998;16(8):728-31.
36. Mannion M. Nutraceutical revolution continues at foundation for innovation in medicine conference. Am J Nat Med. 1998;5:30-3.
37. Rishi R. Nutraceutical: borderline between food and drug. Pharma review. 2006;2006:51-3.
38. Esther B, Rapport L, Lockwood B. What is nutraceutical. Pharm J. 2000;265:57-8.
39. Cockbill C. Food law and functional foods. British Food Journal. 1994.
40. Food U, Administration D. Dietary SupplementsHealth and EducationAct of 1994 (Available from:) http://www. fda. gov/RegulatoryInformation/Legislation/Federal Food Drug and Cosmetic Act FDCAct. Significant Amendments to the FDCAct/ucm148003 htm (Accessed 12 January 2011). 2011.
41. Pandey M, Verma RK, Saraf SA. Nutraceuticals: new era of medicine and health. Asian J Pharm Clin Res. 2010;3(1):11-5.
42. Adelaja AO, Schilling BJ. Nutraceuticals: blurring the line between food and drugs in the twenty-first century. Choices. 1999;14(4):35-9.
43. Richardson DP. Functional foods--shades of gray: an industry perspective. Nutrition Reviews. 1996;54(11):S174.
44. Act A. Dietary Supplement Health and Education Act of 1994 Public Law 103-417 103rd Congress. Public Law. 1994;103:417.
45. Aronson JK. Defining ‘nutraceuticals’: Neither nutritious nor pharmaceutical. British journal of clinical pharmacology. 2017;83(1):8-19.
46. Dureja H, Kaushik D, Kumar V. Development in nutraceuticals. Indian Journal of Pharmacology. 2003;35:363-72.
47. Mobarhan S. Micronutrient supplementation trials and the reduction of cancer and cerebrovascular incidence and mortality. Nutr Rev. 1994;52(3):102-5.
48. de Rijk MC, Breteler MM, den Breeijen JH, Launer LJ, Grobbee DE, van der Meché FG, et al. Dietary antioxidants and Parkinson disease. The Rotterdam Study. Arch Neurol. 1997;54(6):762-5.
49. Agus DB, Gambhir SS, Pardridge WM, Spielholz C, Baselga J, Vera JC, et al. Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J Clin Invest. 1997;100(11):2842-8.
50. Klein C, Sato T, Meguid MM, Miyata G. From food to nutritional support to specific nutraceuticals: a journey across time in the treatment of disease. J Gastroenterol. 2000;35 Suppl 12:1-6.
51. Jialal I, Fuller CJ. Effect of vitamin E, vitamin C and beta-carotene on LDL oxidation and atherosclerosis. Can J Cardiol. 1995;11 Suppl G:97g-103g.
52. Burney PG, Comstock GW, Morris JS. Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer. Am J Clin Nutr. 1989;49(5):895-900.
53. Mathew P, Wyllie R, Van Lente F, Steffen RM, Kay MH. Antioxidants in hereditary pancreatitis. Am J Gastroenterol. 1996;91(8):1558-62.
54. Clark LC, Combs GF, Jr., Turnbull BW, Slate EH, Chalker DK, Chow J, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. Jama. 1996;276(24):1957-63.
55. Ceremuzyński L, Chamiec T, Herbaczyńska-Cedro K. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol. 1997;80(3):331-3.
56. Braeckman J. The extract of Serenoa repens in the treatment of benign prostatic hyperplasia: A multicenter open study. Current Therapeutic Research-clinical and Experimental. 1994;55:776-85.
57. Melchart D, Linde K, Worku F, Sarkady L, Holzmann M, Jurcic K, et al. Results of five randomized studies on the immunomodulatory activity of preparations of Echinacea. J Altern Complement Med. 1995;1(2):145-60.
58. Ernst E. The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava. Ann Intern Med. 2002;136(1):42-53.
59. Krinsky DL. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care: American Pharmacists Association; 2020.
60. Krinsky DL, Ferreri SP, Hemstreet B, Hume AL, Newton GD, Rollins CJ, et al. Handbook of Nonprescription Drugs: An Interactive Approach to Self-care: American Pharmacists Association; 2018.
61. Kokate C, Purohit A, Gokhale S. Nutraceutical and cosmaceutical. Pharmacognosy, 21st edition, Pune, India: Nirali Prakashan. 2002;542:549.
62. Das L, Bhaumik E, Raychaudhuri U, Chakraborty R. Role of nutraceuticals in human health. Journal of food science and technology. 2012;49:173-83.
63. Escott-Stump S. Nutrition and diagnosis-related care: Lippincott Williams & Wilkins; 2008.
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Aug 31, 2024
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How to Cite
Aisha Sethi, Muhammad Abdul Haq Khan, Umbreen Farrukh, Faiqa Dastgir, Muhammad Hussnain Tariq, Misha Arshad, Dilshad Sabir, Ejaz Bashir, Anfas Muneeb, Maira Tahir, Usman Munir, Wajeeha Sultan, Amir Jalal, & Ijaz Ali. (2024). ADVANCEMENT AND CHARACTERIZATION OF NUTRACEUTICALS AS PHYSIOLOGICAL BENEFITS AGAINST MULTIPLE PATHOGENS; A COMPREHENSIVE REVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 31(8), 1901-1921. https://doi.org/10.53555/8gbwsd73
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Author Biographies
Aisha Sethi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Pakistan
Muhammad Abdul Haq Khan
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College UniversityFaisalabad, Pakistan
Umbreen Farrukh
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan
Faiqa Dastgir
Department of Pharmacy, Quaid e Azam University, Islamabad, Pakistan
Muhammad Hussnain Tariq
Department of Pharmacy, Faculty of Pharmaceutical Sciences, Government College University,FaisalabadPakistan
Misha Arshad
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan
Dilshad Sabir
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan
Ejaz Bashir
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan
Anfas Muneeb
Department of Pharmacy, Faculty of Pharmaceutical Sciences, Government College University,FaisalabadPakistan
Maira Tahir
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Pakistan
Usman Munir
Department of Pharmacy, Faculty of Pharmaceutical Sciences, Government College University,FaisalabadPakistan
Wajeeha Sultan
Department of Pharmacy, Faculty of Pharmaceutical Sciences, Government College University,FaisalabadPakistan
Amir Jalal
Sahara Medical College, Narowal,Sialkot. 0542, Punjab. Pakistan.
Ijaz Ali
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan
How to Cite
Aisha Sethi, Muhammad Abdul Haq Khan, Umbreen Farrukh, Faiqa Dastgir, Muhammad Hussnain Tariq, Misha Arshad, Dilshad Sabir, Ejaz Bashir, Anfas Muneeb, Maira Tahir, Usman Munir, Wajeeha Sultan, Amir Jalal, & Ijaz Ali. (2024). ADVANCEMENT AND CHARACTERIZATION OF NUTRACEUTICALS AS PHYSIOLOGICAL BENEFITS AGAINST MULTIPLE PATHOGENS; A COMPREHENSIVE REVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 31(8), 1901-1921. https://doi.org/10.53555/8gbwsd73