FORMULATION, CHARACTERIZATION AND CLINICAL INVESTIGATION OF CORDIA MYXA EXTRACT LOADED EMULSION FOR UV PROTECTION AND ANTI-AGING POTENTIAL
Main Article Content
Keywords
Cordia myxa extract, Antioxidant, Sun Protection Factor (SPF), Skin Elasticity, Anti-inflammatory, Photo-aging
Abstract
Phyto-constituents from Cordia myxa (CM) demonstrate anti-inflammatory, UV protection and anti-aging properties due to its mucilage contents. However, incorporation and stabilization of Cordia myxa extract into a suitable delivery system has always been a challenge. To overcome, this study aimed to formulate a topical formulation, preferably emulsion, characterize its physicochemical properties, quantify its sun protection factor, investigate its effects on skin physical parameters, and evaluate its anti-aging potential, extraction and phyto-chemical analysis of CM extract. Cordia myxa (CM) extract loaded emulsion was formulated and characterized. The Cordia myxa plant extract exhibited anti-oxidant eventual (86.26±1.005% DPPH inhibition), Phenolic contents (214.38±0.412 mg of GAE/g extract), and Flavonoid contents (46.01±0.47 µg of QE/mg of extract) while the extract loaded emulsion demonstrated a sun protection factor of 17. Formulation showed stability in terms of organoleptic, pH, microscopy, and rheological investigations. Non-invasive in vivo investigations on 13 healthy volunteers showed significant improvements in skin elasticity and hydration while the skin erythema and melanin contents were reduced.
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Ammara Choudhry
Faculty of Pharmacy, the Islamia University of Bahawalpur, Bahawalpur, Pakistan
Mudassar Mazher
Department of Pharmacy, the University of Chenab, Gujrat, Pakistan
Muhammad Shahzad Khan
Abbas Institute of Medical Sciences, GC. University, Layyah Campus, Layyah, Pakistan.
Hosh Muhammad Lashari
Department of Pharmacognosy, Faculty of Pharmacy, University of Sindh, Jamshoro Pakistan.
Umer Shaukat
Rashid Latif College of Pharmacy, Lahore Pakistan.
Sidra
Department of Pharmacy, the University of Chenab, Gujrat, Pakistan
Aqna Malik
Department of Pharmacy, the University of Chenab, Gujrat, Pakistan
Muhammad Yousuf
SHIPS (South Punjab Institute of Health Professionals Studies) Jalal Pur Pirwala, Multan.
Zafar Iqbal
College of Pharmacy, Bahawalpur medical And Dental College, Bahawalpur, Pakistan.
Abdul Qudoos
Department of Pharmacy, The Sahara University, Narowal , Pakistan.
Qazi Adnan
Faculty of Pharmacy, the Islamia University of Bahawalpur, Bahawalpur, Pakistan
Maham Amjad
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, GC University, Faisalabad.
Zahara Razzaq
Faculty of Pharmacy, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Aisha Sethi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, GC University, Faisalabad.