FORMULATION AND TESTING OF HERBAL UNDER EYE SERUM PREPARED FROM CITRULLUS LANATUS FRUIT EXTRACT
Main Article Content
Keywords
Natural cosmetics, Dark circles, Citrullus lanatus, under eye serum
Abstract
Background: Dark circles, wrinkles and puffing eyes has become a peril for today’s generation. These problems exerts a significant psychological impact on a person's quality of life, especially among young girls. It may be due to the extensive use of alcohols, allergies, age factors, genetics, nutritional deficiencies and imbalanced diet, lacking of vitamins and minerals like vitamin C, iron or zinc, excessive use of computer and mobile screens, stress, insomnia or sleep disturbances due to hectic life styles.
Objective: The present project was designed to resolve the problem of dark circles and other under eye skin problems with a suitable cost effective formulation with least adverse effects.
Methodology: This formulation of a serum to be applied under eye portion was designed and tested after continuous experimentation using standard reported methods. The quality control tests were performed for samples along with acute dermal toxicity test.. Phase 1 Clinical Trials were conducted on 25 participants aged between 18-55 years after consent and ethical approval. Finally a questionnaire was filled by the participants at the end of study period of two months.
Results: Most of the participants of study exhibited high satisfaction levels with treatment outcomes. No safety concerns were noted. The study revealed that Citrullus lanatus herbal under eye serum is highly significant for treating dark circles, puffy eyes and wrinkles.
Conclusion: The research study could lead to safe and cost effective herbal serum to manage dark circles. However further studies required at molecular level to find out mode of action.
References
2. Chandrashekar BS, Soumya S. Effectiveness and Safety of Topical Under-eye Serum in Patients with Periorbital Hyperpigmentation: An Open-label Single Arm Prospective Study. J Clin Aesthet Dermatol. 2022 Feb;15(2):18-22. PMID: 35309875; PMCID: PMC8884187.
3. Global IVF; 2017. Chemicals in cosmetics can cause infertility. Available from: https://globalivf.com/2017/04/17/chemicals-in-cosmetics-can-cause-infertility/
4. Iasonos, A., O’Quigley, J. Randomised Phase 1 clinical trials in oncology. Br J Cancer 125, 920–926 (2021). https://doi.org/10.1038/s41416-021-01412-y
5. NCATS (2021). Ref: National Center for Advancing Translational Sciences, Genetic and Rare Diseases Information Center. Skin Diseases. (https://rarediseases.info.nih.gov/diseases/diseases-by-category/22/skin-diseases) Accessed 6/4/2021.
6. Erhirhie EO. and Ekene NE. (2013). Medicinal Values on Citrullus lanatus (Watermelon): Pharmacological Review. International Journal of Research in Pharmaceutical and Biomedical Sciences . Vol. 4 (4) Oct – Dec 2013 Page 1305-1312
https://doi.org/10.1111/jfbc.13763
7. Nadeem M, Navida M, Ameer K, Iqbal A, Malik F, Nadeem MA, Fatima H, Ahmed A, Din A. A comprehensive review on the watermelon phytochemical profile and their bioactive and therapeutic effects. Korean J Food Preserv, 29(4), 546-576 (2022). https://doi.org/10.11002/kjfp.2022.29.4.546
8. Mei X. Chen, Kenneth S. Alexander, and Gabriella Baki (2016). Formulation and Evaluation of Antibacterial Creams and Gels Containing Metal Ions for Topical Application. Journal of Pharmaceutics Volume 2016, Article ID 5754349, 10 pages http://dx.doi.org/10.1155/2016/5754349
9. OECD (2017). OECD Guideline for Testing of Chemicals: Acute Dermal Toxicity – Fixed Dose Procedure (Test No.402). OECD, Paris.
10. Roberts W. Periorbital Hyperpigmentation: Review of Etiology, Medical Evaluation, and Aesthetic Treatment. Journal of drugs in dermatology : JDD. 2014;13:472–482. [PubMed] [Google Scholar]
11. Clinical Trial Phases https://med.uc.edu/depart/psychiatry/research/clinical-research/crm/trial-phases-1-2-3-defined sited on 22 Sep 2023
12. Vrcek I, Ozgur O, Nakra T. Infraorbital Dark Circles: A Review of the Pathogenesis, Evaluation and Treatment. J Cutan Aesthet Surg. 2016 Apr-Jun;9(2):65-72. doi: 10.4103/0974-2077.184046. PMID: 27398005; PMCID: PMC4924417.