VASCULITIS UNVEILED: A DETAILED CASE REPORT
Main Article Content
Keywords
vasculitis, inflammation of blood vessels, c-ANCA, p-ANCA, serum ANA IgG
Abstract
Vasculitis is characterized by inflammation of the blood vessels that usually presents with fever, arthralgias, itching, purpural rashes, ulcers, weakness, and other symptoms (1). It can be classified in various ways and the age of presentation will depend on the type of vasculitis. However, regardless of the type, it commonly occurs in adults older than 50 years old. The exact causative factors or agents for vasculitis are unknown but they are usually classified under autoimmune diseases and infections, which includes rheumatoid arthritis, lupus, and hepatitis (2). In this report, we describe the case of a 50-year-old female who presented to OPD of a tertiary care hospital in Islamabad that was a diagnosed case of chronic gastroenteritis from 2 months, with complaints of fever, vomiting, diarrhea, itching, painful blisters on feet, thigh, and abdomen in addition to arthralgias in both knees. The patient was conscious and admitted to female medical ward. She was treated with systemic corticosteroids, topical corticosteroids, emollients, and anti-histamines for her skin blisters. Co-Amoxiclav was administered in IV form for chronic gastroenteritis. NSAID was given for arthralgias. She was also given Ringer Lactate in IV form to treat dehydration, loperamide for vomiting and domperidone for diarrhea. Serum ANA IgG came out as Non-Reactive. CBC indicated anemia and thrombocytopenia. ESR and CRP were raised. The diagnosis was made clinically.
References
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2. Clinic manifestations in granulomatosis with polyangiitis. Greco, A., et al. 2, s.l. : International journal of immunopathology and pharmacology, 2016, Vol. 29.
3. Overview of the 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Jennette, J.C. s.l. : Clinical and Experimental Nephrology, 2013, Vol. 17.
4. Introduction, epidemiology and classification of vasculitis. A.Watts, Richard and Robson, Joanna. 1, s.l. : Best Practice & Research Clinical Rheumatology, 2018, Vol. 32, pp. 3-20.
5. Vasculitis. Jatwani, Shraddha and Goyal, Amandeep. 2023, In StatPearls. StatPearls Publishing.
6. Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis. Stone, John H., et al. 3, s.l. : The NEW ENGLAND JOURNAL of MEDICINE, 2010, Vol. 363.
7. Nova, Amina Nur. Approach to a patient with vasculitis. slideshare. [Online] slideshare a Scribd company, October 17, 2015. https://www.slideshare.net/slideshow/approach-to-a-patient-with-vasculitis/54063344#3
8. John Hopkins. Symptoms of Vasculitis. John Hopkins Vasculitis Center. [Online] https://www.hopkinsvasculitis.org/vasculitis/symptoms-vasculitis/
9. Optimised glucocorticoid therapy: the sharpening of an old spear . Buttgereit, Frank, Burmester, Gerd-Rudiger and Lipworth, Brian J. 9461, Lancet : s.n., 2005, Vol. 365.