ANTIDIABETIC AND ANTIOXIDANT POTENTIAL OF COPRINUS COMATUS IN ALLOXAN-INDUCED DIABETIC RATS MODELS
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Keywords
Mushrooms, Bioactive Compounds, Antioxidant and anti-diabetic Activity
Abstract
Background: Mushrooms are used as nutraceuticals from a long time. In the present era they got attention of researchers due to a large number of bioactive compounds. Coprinus comatus (C. comatus) is a therapeutic mushroom helpful in the management of Diabetes Mellitus. The pancreas having beta cells were very susceptible to Reactive Oxygen Species (ROS) attack, producing an unbalance insulin productions.
Methodology: The study was organized to investigate the C.comatus methanolic extracts for antidiabetic and antioxidant activity. Sixty (60) male rats were divided into five groups, G1 was consist of normal control group (NC), G2 was positive control (PC) G3 was Diabetic Control (DC) (G4 and G5: Giving 200 and 400 mg/kg BW mushroom extracts). All the parameters were analyzed using the ANOVA software.
Results: On the bases of obtained results, the 400mg/ kg BW C. comatus extracts significantly reduced the fasting blood glucose level (FBC) up to 22.86% in G5 group.
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Jan Baz Khan
Department of Botany, Hazara University, Mansehra 21300, Pakistan
Salma Gul
Department of Chemistry, Women University Swabi, Pakistan
Shazia Sakhi
Centre for Plant Sciences and Biodiversity, University of Swat, Pakistan
Shamaila Irum
Department of Zoology, University of Gujrat, Pakistan
Amtul Sami
Department of Health Biotechnology, Women University Swabi, Pakistan
Faryal Ali
Department of Public Health and Informatics, Women University Swabi, Pakistan
Hikmat Ullah Jan
Department of Botany, Government Superior Science College Peshawar, Higher Education Department KP, Pakistan
Sumaira Salahuddin Lodhi
Department of Biochemistry, Hazara University, Mansehra 21300, Pakistan
Rahmat Ali
Department of Biotechnology, University of Science and Technology, Bannu, Pakistan
Muhammad Fiaz
Department of Botany, Hazara University, Mansehra 21300, Pakistan
Nosheen Khalid
Pharmacy Manager, THQ Hospital Hazro, Attock, Punjab, Pakistan
Mahreen Khalid
Regional Agricultural Research Institute, Bahawalpur 63100, Pakistan
Gulnaz Parveen
Department of Botany, Women University Swabi, Pakistan