EFFECT OF CASSIA AURICULATA FLOWERS, LEVES AND SEEDS DOSE DEPENDENT STUDY IN STREPTOZOTOCIN - INDUCED DIABETIC RATS.
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Keywords
blood glucose, plasma insulin, pancreas, Cassia auriculata
Abstract
Diabetes is a major health problem affecting major populations worldwide. Cassia auriculata L. (Ceasalpiniaceae) has been used traditionally as antidiabetic and has been proven scientifically to possess high antioxidant activity and anticancer properties. Cassia auriculata L. is a shrub that has attractive yellow flowers, commonly used for the treatment of skin disorders and body odour. It is a native plant present in different parts of India. Indigenous people use various parts of the plant for diabetes mellitus. Streptozotocin (STZ)-nicotinamide type 2 model shares a number of features with human type 2 diabetes and is characterized by moderate stable hyperglycemia, glucose intolerance, altered but significant glucose-stimulated insulin secretion, in vivo and in vitro. Oral administration of Cassia auriculta flower extract (CFEt), leaf extract (CLEt) and seed extract (CSEt) at 0.45 mg/kg body weight to diabetic rats for 45 days. In the present study, we have investigated of Tanner’s cassia CFEt, CLEt and CSEt on glucose levels were assayed. Our results indicate that administration of CFEt, CLEt and CSEt to diabetic animals normalizes blood glucose and causes marked improvement of altered blood glucose and plasma insulin during diabetes. The CFEt administration showed more effective than CLEt, CSEt and glibenclamide.
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Murugan P
Principal (i/c), Assistant professor of Biochemistry, Faculty of Science, Bharathidhasn University Model College, Vedharanyam-614810. Tamil Nadu, India. Tel: + 9791620088
Sakthivel V
Principal i/c, Assistant professor, Department of Biotechnology, Bharathidhasn University Model College, Thiruthuraipoondi-614715. Tamil Nadu, India.
Jawahar S
Assistant professor of Agronomy, Faculty of Agriculture, Annamalai University, Annamalai nagar-608002, Tamil Nadu, India