EFFECT OF CASSIA AURICULATA ON LIPID PROFILES IN STREPTOZOTOCIN–NICOTINAMIDE INDUCED TYPE 2 DIABETES MELLITUS
Main Article Content
Keywords
Cassia auriculta, lipoproteins, lipids, diabetes, glibenclamide
Abstract
In experimental diabetes, enzymes of glucose and fatty acid metabolism are markedly altered. A study was undertaken to evaluate the antihyperlipidemic activity of Cassia auriculta flower extract (CFEt), leaf extract (CLEt) and seed extract (CSEt). Oral administration of CFEt (0.45 g/kg), leaf extract (0.45 g/kg) seeds extract CSEt (0.45 g/kg) to streptozotocin-nicotinamide induced diabetic rats for 45 days, significantly reduced the elevated serum very low density lipoprotein (VLDL) and low density lipoprotein (LDL) – cholesterol levels and significantly increased the serum high-density lipoprotein (HDL)-cholesterol. CFEt showed a better effect when compared with CLEt and CSEt. Results of the present study indicate that CFEt, CLEt and CSEt showed antihyperlipidemic effect in addtion to its antidiabetic effect in type 2 diabetic rats.
References
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21. Murugan P. Effect of Cassia auriculata L on erythrocyte membrane bound enzymes andantioxidant status in experimental diabetes. International Journal of Recent Advances in Multidisciplinary Research. Vol. 02, Issue 12, pp.5760-5764, December, 2015
22. Murugan P. Effect of Cassia auriculata L on plasma antioxidants in streptozotocin-nicotinamide induced experimental diabetes. International Journal of Information Research and Review. Vol. 02, Issue, 05, pp.6930-6934, May, 2015b.
23. Murugan P. Preventive effects of Cassia auriculata on brain lipid peroxidation streptozotocin diabetic rats. Internat J Inform Res Rev. 2015a; 05: 6924-6929.
24. Murugan P. Taner’s Cassia (Cassia auriculata L) extract prevents hemoglobin glycation tail tendon collagen properties in experimental diabetic rats. J cell tissue res. 2010; 10 (1): 2109-2114.
25. Murugan P. Taner’s Cassia (Cassia auriculata L) extract prevents hemoglobin glycation tail tendon collagen properties in experimental diabetic rats. Journal of cell and tissue research. 2010; 10 (1): 2109-2114.
26. Pari L, Murugan P. Influence of Cassia auriculata flowers on Insulin Receptors in Streptozotocin Induced Diabetic Rats: Studies on Insulin Binding to Erythrocytes. African Journal of Biochemistry Research. 2007; 1 (7): 148-155.
27. Philipp B, Shapiro DJ. (1970). Improved methods for the assay and activation of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. J Lipid Res 20: 588 – 93.
28. Rimando AM, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J Agric Food Chem 2002;50:3453-3457.
29. Shrotri DS, Aiman R. The relationship of the post-absorptive state to the hypoglyceamic action. Ind. J. Med. Res.1960. 48: 162 – 168.
30. Sudhakar Nayak, S & T.N. Pattabiraman: A new colorimetric method for the estimation of glycosylated hemoglobin. Clin. Chem. Acta. 1981, 109, 267 - 274.
31. Taskinen M-R, NikkilaEA, Kunsi T, Harno K. Lipoprotein lipase activity and serum lipoproteins in untreated type 2 (insulin-independent) diabetes associated with obesity. Diabetologia 1982;22:46-50
32. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract . 2011; 94:311–321.
33. Yilmaz O, Ersan Y, Dilek Ozsahin A, Ozturk AI, Ozkan Y. Consequences of the combined α-tocopherol, ascorbic acid and α-lipoic acid on the glutathione, cholesterol and fatty acid composition in muscle and liver of diabetic rats. Iran J Basic Med Sci. 2013; 16:165–172.
34. Zare K, Fatemi Tabatabaei SR, Shahriari A, Jafari RA. The effect of butter oil on avoidance memory in normal and diabetic rats. Iran J Basic Med Sci . 2012; 15:983–989.
2. Babu PS, Srinivasan K. Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol Cell Biochem 1997;166:169-175.
3. Bannon, P: Effect of pH on the elimination of the labile fraction of glycosylated haemoglobin. Clin. Chem. 1982, 28, 2183.
4. Bergman RN, Ader M. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab 2000;11:351-356.
5. Chauhan UPS, Jagi CB, Singh VN. Incorporation of 32Pi into plasma phosphatidylcholine of diabetic rats. Ind J Nucl Med 1987;2:92-98.
6. Drabkin, D.L & J.M. Austin: Spectrophotometric constants for common hemoglobin derivatives in human, dog and rabbit blood. J. Biol. Chem. 1932, 98, 719 - 733.
7. Duncan BD. (1957). Multiple range tests for correlated and heteroscedastic means. Biometrics. 13: 359-364.
8. Fruchart JC, Duriez P. [Anti-cholesterol agents, new therapeutic approaches]. Ann Pharm Fr 2004;62:3-18.
9. Fruchart JC, Duriez P. [Anti-cholesterol agents, new therapeutic approaches]. Ann Pharm Fr 2004;62:3-18.
10. Gervois P, Torra IP, Fruchart JC, Staels B. Regulation of lipid and lipoprotein metabolism by PPAR activators. Clin Chem Lab Med 2000;38:3-11.
11. Ghorbani A. Phytotherapy for diabetic dyslipi-demia: evidence from clinical trials. Clin Lipidol . 2013; 8:311–319.
12. Gibbons GF. Hyperlipidemia of diabetes. Clin Sci 1986;71:477-86.
13. Gilde AJ, Van Bilsen M. Peroxisome proliferator-activated receptors (PPARS): regulators of gene expression in heart and skeletal muscle. Acta Physiol Scand 2003;178:425-434.
14. Gomez-Perez FJ, Aguilar-Salinas CA, Almeda-Valdes P, Cuevas-Ramos D, Lerman Garber I, Rull JA. HbA1c for the diagnosis of diabetes mellitus in a developing country. Arch Med Res . 2010; 4:302–308.
15. John A. Lott & K. Turner: Evaluation of trinder’s glucose oxidase method for measuring glucose in serum and urine. Clin. Chem. 1975, 21/12, 1754-1760.
16. Kanters SDJMN, Banga JD, Erkelens DW. Lipid-lowering therapy in diabetes mellitus. The Netherlands J Med 2001;58:214-222.
17. Latha M, Pari L . Preventive effects of Cassia auriculata L. flowers on brain lipid peroxidation in rats treated with streptozotocin diabetes. Molecular and Cellular Biochemistry.2003, 243, 23–28.
18. Lopaschuk GD, Tahiliani AG, Vadlamudi RV, Katz S, McNeill JH. Cardiac sarcoplasmic reticulum function in insulin- or carnitine-treated diabetic rats. Am J Physiol 1983;245:H969-976.
19. Masiello, P., C. Broca, R. Gross, M. Roye, M. Manteghetti, D. Hillaire-Buys, M. Novelli & G. Ribes. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes. 1998; 47: 224-229.
20. McKenney JM. (2001). Pharmacotherapy of dyslipidemia. Cardiovasc Drugs Ther. 15: 413-422.
21. Murugan P. Effect of Cassia auriculata L on erythrocyte membrane bound enzymes andantioxidant status in experimental diabetes. International Journal of Recent Advances in Multidisciplinary Research. Vol. 02, Issue 12, pp.5760-5764, December, 2015
22. Murugan P. Effect of Cassia auriculata L on plasma antioxidants in streptozotocin-nicotinamide induced experimental diabetes. International Journal of Information Research and Review. Vol. 02, Issue, 05, pp.6930-6934, May, 2015b.
23. Murugan P. Preventive effects of Cassia auriculata on brain lipid peroxidation streptozotocin diabetic rats. Internat J Inform Res Rev. 2015a; 05: 6924-6929.
24. Murugan P. Taner’s Cassia (Cassia auriculata L) extract prevents hemoglobin glycation tail tendon collagen properties in experimental diabetic rats. J cell tissue res. 2010; 10 (1): 2109-2114.
25. Murugan P. Taner’s Cassia (Cassia auriculata L) extract prevents hemoglobin glycation tail tendon collagen properties in experimental diabetic rats. Journal of cell and tissue research. 2010; 10 (1): 2109-2114.
26. Pari L, Murugan P. Influence of Cassia auriculata flowers on Insulin Receptors in Streptozotocin Induced Diabetic Rats: Studies on Insulin Binding to Erythrocytes. African Journal of Biochemistry Research. 2007; 1 (7): 148-155.
27. Philipp B, Shapiro DJ. (1970). Improved methods for the assay and activation of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. J Lipid Res 20: 588 – 93.
28. Rimando AM, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J Agric Food Chem 2002;50:3453-3457.
29. Shrotri DS, Aiman R. The relationship of the post-absorptive state to the hypoglyceamic action. Ind. J. Med. Res.1960. 48: 162 – 168.
30. Sudhakar Nayak, S & T.N. Pattabiraman: A new colorimetric method for the estimation of glycosylated hemoglobin. Clin. Chem. Acta. 1981, 109, 267 - 274.
31. Taskinen M-R, NikkilaEA, Kunsi T, Harno K. Lipoprotein lipase activity and serum lipoproteins in untreated type 2 (insulin-independent) diabetes associated with obesity. Diabetologia 1982;22:46-50
32. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract . 2011; 94:311–321.
33. Yilmaz O, Ersan Y, Dilek Ozsahin A, Ozturk AI, Ozkan Y. Consequences of the combined α-tocopherol, ascorbic acid and α-lipoic acid on the glutathione, cholesterol and fatty acid composition in muscle and liver of diabetic rats. Iran J Basic Med Sci. 2013; 16:165–172.
34. Zare K, Fatemi Tabatabaei SR, Shahriari A, Jafari RA. The effect of butter oil on avoidance memory in normal and diabetic rats. Iran J Basic Med Sci . 2012; 15:983–989.
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Mar 1, 2021
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How to Cite
Murugan P, & Sakthivel V. (2021). EFFECT OF CASSIA AURICULATA ON LIPID PROFILES IN STREPTOZOTOCIN–NICOTINAMIDE INDUCED TYPE 2 DIABETES MELLITUS. Journal of Population Therapeutics and Clinical Pharmacology, 28(01), 73-79. https://doi.org/10.53555/jptcp.v28i01.2440
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Author Biographies
Murugan P
Principal i/c, Assistant professor, Department of Biochemistry, Government arts and science college, Vedharanyam-614810. Tamil Nadu, India
Sakthivel V
Principal i/c, Assistant professor, Department of Biotechnology, Government arts and science college, Thiruthuraipoondi-614715. Tamil Nadu, India.
How to Cite
Murugan P, & Sakthivel V. (2021). EFFECT OF CASSIA AURICULATA ON LIPID PROFILES IN STREPTOZOTOCIN–NICOTINAMIDE INDUCED TYPE 2 DIABETES MELLITUS. Journal of Population Therapeutics and Clinical Pharmacology, 28(01), 73-79. https://doi.org/10.53555/jptcp.v28i01.2440