EFFECT OF PTEROSTILBENE COMPARED TO TETRAHYDROCURCUMIN ON ERYTHROCYTE MEMBRANE BOUND ENZYMES AND ANTIOXIDANT STATUS IN DIABETES
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Keywords
Tetrahydrocurcumin, pterostilbene, Erythrocyte antioxidants, Lipid peroxidation, Ca2+-ATPase, Na+/K+-ATPase, Mg2+-ATPase, Streptozotocin, Nicotinamide.
Abstract
Pterocarpus marsupium has been used in the treatment of toothache, diarrhoea, heartburn, urinary tract infections, boils, sores and skin diseases. P. marsupium has been used for many years in the treatment of diabetes mellitus. Pterostilbene was found to be one of the active constituents in the extracts of the heartwood of Pterocarpus marsupium. Pterostilbene, a phenolic compound derived from resveratrol, possesses greater bioavailability than its parent compound due to the presence of two methoxyl groups. In this review, the beneficial effects of pterostilbene on diabetes, liver steatosis and dyslipidemia are summarized. Pterostilbene is a useful bioactive compound in preventing type 1 diabetes, insulin resistance and type 2 diabetes in animal models. Hyperlipidemia is an associated complication of diabetes mellitus. Oral administration of pterostilbene (40 mg/kg body weight ) THC (80 mg/kg body weight) to diabetic rats for 45 days. The effect of pterostilbene and THC on glucose, insulin, haemoglobin, glycosylated haemoglobin, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxide (Gpx), glutathione-S-transferase (GST), reduced glutathione (GSH) and membrane bound enzymes were studied. The effect of pterostilbene was compared with THC. The levels of blood glucose, glycosylated haemoglobin, erythrocyte TBARS, were increased significantly whereas the level of plasma insulin and haemoglobin, erythrocyte antioxidants (SOD, CAT, GPx, GST and GSH), membrane bound total ATPase, Na+/K+-ATPase, Ca2+- ATPase, Mg2+- ATPase were decreased significantly in diabetic rats. Administration of pterostilbene and THC to diabetic rats showed decreased level of blood glucose, glycosylated haemoglobin and erythrocyte TBARS. In addition the levels of plasma insulin, haemoglobin, erythrocyte antioxidants and the activities of membrane bound enzymes also were increased in pterostilbene and THC treated diabetic rats. The present study indicates that the pterostilbene and THC possesses a significant beneficial effect on erythrocyte membrane bound enzymes and antioxidants defense in addition to its antidiabetic effect.
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MURUGAN P
Principal (i/c), Assistant professor of Biochemistry, Faculty of Science, Bharathidhasn University Model College, Vedharanyam-614810. Tamil Nadu, India.Tel: + 9791620088,
SAKTHIVEL V
Principal i/c, Assistant professor, Department of Biotechnology, Bharathidhasn University Model College, Thiruthuraipoondi-614715. Tamil Nadu, India.