Assessment Of Antioxidant and Anti-inflammatory Properties Of Gold Nanoparticles Synthesized Using Pterocarpus Santa- An In Vitro Study
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Keywords
Gold Nanoparticles, Pterocarpus santa, A-PRF+, Periodontal Regeneration, antioxidant and anti-inflammatory properties
Abstract
Background: Pterocarpus santa which is popularly known as red sandal or yerra chandanam or lal chandan, is one of most expensive plant in the world, which is used for its anti inflammatory, antipyretic and anti hyperglycemic properties from the ancient times. Aim of the present study is to synthesize, characterize and assess antioxidant and anti-inflammatory properties of red sandal gold nanoparticles.
Materials and methods: Preparation and characterisation of red sandal gold nanoparticles (AuNP) and its characterisation by UV spectroscopy, transmission electron microscopy (TEM) and fourier-transform infrared spectroscopy (FTIR). Antioxidant and anti-inflammatory activity of gold nanoparticles were assessed using DPPH assay and BSA method respectively.
Results: The production of AuNPs was monitored using visual color change and UV–visible spectroscopy and Pterocarpus santa mediated gold nanoparticles are spherical in shape and size of 2-35 nanometers shown in TEM analysis. Biosynthesized red sandal AuNP showed 83% highest inhibitory activity of DPPH radical at highest concentration of 50μg/ml. Highest inhibition and maximum protective activity of red sandal AuNP was 80.5% at concentration of 50μg/mL.
Conclusion: Red sandal mediated green synthesis of gold nanoparticles exhibited good antioxidant and anti-inflammatory properties and can be applied in regenerative periodontal therapy in the future studies.
References
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