HIBISCUS ROSA-SINENSIS AND AZADIRACHTA INDICA HEALING FOR GETTING SKIN INFLAMMATION NATURALLY: A REVIEW
Main Article Content
Keywords
Skin inflammation, Anthocyanins, azadirachtin, Azadirachtin
Abstract
Hibiscus rosa-sinensis, commonly known as China rose, is a member of the Malvaceae family and is widely distributed across the world. In Indian traditional medicine, its leaves, bark, roots, and flowers have been extensively used to treat various ailments. This plant has significant medicinal value, particularly for treating wounds, inflammation, fever, coughs, diabetes, bacterial and fungal infections, hair loss, and gastric ulcers, especially in tropical countries.
Phytochemical studies have identified that the primary bioactive compounds responsible for its medicinal properties include flavonoids, tannins, terpenoids, saponins, and alkaloids. Numerous research studies have shown that different parts of Hibiscus rosa-sinensis possess antioxidant, antimicrobial, antidiabetic, antiulcer, hepatoprotective, antifertility, and anti-inflammatory properties, making it effective in treating a wide range of diseases. Flavonoids, in particular, are known to aid in wound healing due to their astringent and antimicrobial properties. Additionally, Hibiscus rosa-sinensis is often used in various herbal mixtures and beverages. This review seeks to emphasize the therapeutic potential of Hibiscus rosa-sinensis in modern medicine.
References
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8) Shaikh, Mohammed Zuber, Md Rageeb Md Usman, and Abhishek Sunil Shirsath. "Development Of Antiseptic Soap By Using Calendula Officinalis And Althaea Officinalis." Journal of Survey in Fisheries Sciences (2023): 725-733.
9) Patil, Jitesh Narendra, et al. "Formulation and evaluation of camphor aloe soap." World J. Pharm. Res 12 (2023): 1257-1273.
10) https://en.wikipedia.org/w/index.php?title=Hibiscus_rosasinensis&oldid=1235606426 ( Wikipedia)
11) https://www.researchgate.net/publication/277309261_Skin_Deep_The_Basics_of_Human_Skin_Structure_and_Drug_Penetration
12) Da-Costa-Rocha, Inês, et al. "Hibiscus sabdariffa L.–A phytochemical and pharmacological review." Food chemistry 165 (2014): 424-443.
13) Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123.
14) Ali, Badreldin H., Naser Al Wabel, and Gerald Blunden. "Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review." Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 19.5 (2005): 369-375.
15) Al-Hashimi, Alaa G. "Antioxidant and antibacterial activities of Hibiscus sabdariffa L. extracts." African Journal of Food Science 6.21 (2012): 506-511.
16) Kumar, Sanjay, et al. "Analgesic, anti-inflammatory and anti-pyretic effects of Azadirachta indica (Neem) leaf extract in albino rats." Int J Sci Res 4.8 (2015): 713-21.
17) Ahmad, Sharique, et al. "Biological detail and therapeutic effect of azadirachta indica (neem tree) products-a review." J. Evid. Based Med. Healthc 6.22 (2019): 1607-1612.
18) Cerella, Claudia, Mario Dicato, and Marc F. Diederich. "Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf..."
19) Girish, K., and Bhat S. Shankara. "Neem–a green treasure." Electronic journal of Biology 4.3 (2008): 102-111.
20) Rahmani, Arshad, et al. "Pharmacological and therapeutic potential of neem (Azadirachta indica)." Pharmacognosy Reviews 12.24 (2018): 250-255.
21) Mahadevan, N., and Pradeep Kamboj. "Hibiscus sabdariffa Linn.–an overview." (2009).
22) Sharma, Satish Kumar, and Suruchi Singh. "Antimicrobial herbal soap formulation." J. Pharmaceut. Res. Int 32.36 (2020): 82-88.
23) Mohamed, Bahaeldeen Babiker, Abdelatif Ahmed Sulaiman, and Abdelhafiz Adam Dahab. "Roselle (Hibiscus sabdariffa L.) in Sudan, cultivation and their uses." Bull. Environ. Pharmacol. Life Sci 1.6 (2012): 48-54.
24) El Bilali, Hamid. "State and contours of research on roselle (Hibiscus sabdariffa L.) in Africa." Open Agriculture 9.1 (2024): 20220336.
25) Almukashir, Mukhtar, et al. "Potent antibacterial activity of Terminalia chebula-based herbal soap formulation against Propionibacterium acnes and its cytotoxic evaluation on human skin fibroblast cells." Journal of Applied Pharmaceutical Research 11.5 (2023): 01-08.
26) Devi, A. Seetha, et al. "Formulation and Evaluation of Antimicrobial Herbal Soap." International Journal of Pharmaceutical Sciences Review and Research 71.2 (2021): 122-125.
27) Bhavani, J., et al. "FORMULATION AND EVALUATION OF HERBAL SOAP BY USING NATURAL INGREDIENTS." (2023).
28) Talreja, Shreya, Dr Tiwari, and Archana Bharti. "Formulation and evaluation of herbal soap by using moringa oleifera as main active constituents." European Chemical Bulletin 12 (2023): 2121-2141.
29) Gupta, Akash, et al. "Therapeutics role of neem and its bioactive constituents in disease prevention and treatment." Journal of Pharmacognosy and Phytochemistry 8.3 (2019): 680-691.
30) Kale, Mayuri, Anilkumar Aher, and Shraddha Dhanokar. "Authentication of Azadirachta indica (Neem) plant by pharmacognostic, physicochemical and phytochemical evaluation." Current Trends in Pharmacy and Pharmaceutical Chemistry 2.3 (2020): 109-115.
31) Singh, Varinder, et al. "An insight into the dermatological applications of neem: a review on traditional and modern aspect." Recent Advances in Anti-Infective Drug Discovery Formerly Recent Patents on Anti-Infective Drug Discovery 16.2 (2021): 94-121.
32) Kadir, Afreen, et al. "IN-DEPTH REVIEW ON TAXONOMY, PHYTOCHEMISTRY,
TRADITIONAL USES AND PHARMACOLOGICAL SIGNIFICANCE OF AZADIRACHTA INDICA PLANT." European Journal of Biomedical 11.6 (2024): 277-284.
33) Koul, A., et al. "Potential of Azadirachta indica against Salmonella typhimurium-induced inflammation in BALB/c mice." Inflammopharmacology 17 (2009): 29-36.
34) Eid, Ahmad, Nidal Jaradat, and Nagib Elmarzugi. "A Review of chemical constituents and traditional usage of Neem plant (Azadirachta Indica)." Palestinian Medical and Pharmaceutical Journal 2.2 (2017)
35) Hussein, M. E., et al. "Immunomodulatory and anti-inflammatory activities of the defatted alcoholic extract and mucilage of Hibiscus sabdariffa L. leaves, and their chemical characterization." Journal of Pharmacognosy and Phytochemistry 8.4 (2019): 982-990.
36) Gupta, Anshita, et al. "Exploration of anti-inflammatory activity of aquaeous extract of Hibiscus rosa sinesis (Malvacae)." Research Journal of Pharmacognosy and Phytochemistry 6.3 (2014): 109-111.
37) Guddeti, Venkateswarlu, et al. "EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF HIBISCUS ROSA SINENSIS Linn. FLOWER EXTRACT IN RATS." International Journal of Pharmaceutical, Chemical & Biological Sciences 5.3 (2015).
38) Mounika, B., and I. Bala Tripura Sundari. "Development and evaluation of anti-inflammatory activity of Hibiscus emulgel." International Journal of Ayurveda and herbal medicine 2 (2019): 3464-3476.
39) Sivaraman, Chinju M., and Fels Saju. "Medicinal value of Hibiscus rosa sinensis: a review." International Journal of Pharmacognosy and Chemistry (2021): 1-11.
40) Sultana, Sayema, et al. "In-vitro antiinflammatory, anti-oxidant and in-vivo analgesic, anti-diarrheal activities of fractional leaf extracts of Hibiscus surattensis." European Journal of Pharmaceutical and Medical Research 5.4 (2018): 167-173.
41) Patel, Shilpi, and Madhavi Adhav. "Comparative phytochemical screening of ethanolic extracts (flower and leaf) of morphotypes of Hibiscus Rosa-sinensis Linn." Journal of Pharmacognosy and Phytochemistry 5.3 (2016): 93-95.
42) Yakubu, Medinat Abbas, et al. "Chemical Constituents and Effect of Ethanol Leaf Extract of Hibiscus articulatus Hochst. ex A. Rich.(Malvaceae) on Glucose-and Streptozotocin-Induced Hyperglycaemia using Wistar Rats." Journal of Current Biomedical Research 2.5, September-October (2022): 503-532.
43) Sharma, S. A. F. A. L., et al. "Formulation And Evaluation of Herbal Soap Taking Different Bioactive Plants by Cold Saponification Method." Int J Curr Pharm Res 14.5 (2022): 30-35.
44) Aishwarya, Shinde, Kuskar Sharmila, and Kalyani Chande. "FORMULATION AND EVALUATION OF HERBAL SOAP." INNOVATIONS IN LIFE SCIENCES: 119.
45) Goukonde, Rekha, et al. "Formulation and evaluation of herbal scrub soap." World Journal of Biology Pharmacy and Health Sciences 18.3 (2024): 354-370.
46) Shah, Madeha, Zahida Parveen, and Muhammad Rashid Khan. "Evaluation of antioxidant, anti-inflammatory, analgesic and antipyretic activities of the stem bark of Sapindus mukorossi." BMC complementary and alternative medicine 17 (2017): 1-16.
47) Priyanka, M. "Herbal paper soap (Turmeric)."
48) Gorde, Shankar Vishnu, et al. "FORMULETION AND EVALUATION OF ALOE VERA SOAP." EPRA International Journal of Research and Development (IJRD) 9.5 (2024): 486-491.
49) Chou, Shun-Ting, et al. "Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation." Journal of ethnopharmacology 194 (2016): 617-625.
50) Sogo, Takayuki, et al. "Anti‐inflammatory activity and molecular mechanism of delphinidin 3‐sambubioside, a Hibiscus anthocyanin." BioFactors 41.1 (2015): 58-65.
51) Raduan, S. Z., et al. "Anti-inflammatory effects of Hibiscus rosa-sinensis L. and Hibiscus rosa-sinensis var. alba ethanol extracts." Int J Pharm Sci 5.4 (2013): 754-762.
2) Kassakul, W., Praznik, W., Viernstein, H., Hongwiset, D., Phrutivorapongkul, A., & Leelapornpisid, P. (2014). Characterization of the mucilages extracted from hibiscus rosa-sinensis linn and hibiscus mutabilis linn and their skin moisturizing effect. Int J Pharm Sci, 6(11), 453-7.
3) Arun, Sonvane Komal. "FORMULATION AND EVALUATION OF HERBAL SOAP." World Journal of Pharmaceutical Research 12.9 (2023): 2136-2147.
4) Michelle, Shareen, et al. "Inhibitory Power of Liquid Soap Made from Hibiscus Flower (Hibiscus rosasinensis L.) on The Growth of Bacterial Colonies on Hands."
5) Missoum, Asmaa. "An update review on Hibiscus rosa sinensis phytochemistry and medicinal uses." Journal of ayurvedic and herbal medicine 4.3 (2018): 135-146.
6) Blessy Jacob, Ciyamol, V. Chandy Formulation and Evaluation of Herbal Soap. Research & Reviews: A Journal of Pharmacology. 2019; 9(2): 22–29.
7) Akuaden, Namo Jeremiah, I. Y. Chindo, and Joel Ogboji. "Formulation, Physicochemical and Antifungi Evaluation of Herbal Soaps of AzadiractaIndica and ZiziphusMauritiana." IOSR Journal of Applied Chemistry 12.8 (2019): 26-34.
8) Shaikh, Mohammed Zuber, Md Rageeb Md Usman, and Abhishek Sunil Shirsath. "Development Of Antiseptic Soap By Using Calendula Officinalis And Althaea Officinalis." Journal of Survey in Fisheries Sciences (2023): 725-733.
9) Patil, Jitesh Narendra, et al. "Formulation and evaluation of camphor aloe soap." World J. Pharm. Res 12 (2023): 1257-1273.
10) https://en.wikipedia.org/w/index.php?title=Hibiscus_rosasinensis&oldid=1235606426 ( Wikipedia)
11) https://www.researchgate.net/publication/277309261_Skin_Deep_The_Basics_of_Human_Skin_Structure_and_Drug_Penetration
12) Da-Costa-Rocha, Inês, et al. "Hibiscus sabdariffa L.–A phytochemical and pharmacological review." Food chemistry 165 (2014): 424-443.
13) Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123.
14) Ali, Badreldin H., Naser Al Wabel, and Gerald Blunden. "Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review." Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 19.5 (2005): 369-375.
15) Al-Hashimi, Alaa G. "Antioxidant and antibacterial activities of Hibiscus sabdariffa L. extracts." African Journal of Food Science 6.21 (2012): 506-511.
16) Kumar, Sanjay, et al. "Analgesic, anti-inflammatory and anti-pyretic effects of Azadirachta indica (Neem) leaf extract in albino rats." Int J Sci Res 4.8 (2015): 713-21.
17) Ahmad, Sharique, et al. "Biological detail and therapeutic effect of azadirachta indica (neem tree) products-a review." J. Evid. Based Med. Healthc 6.22 (2019): 1607-1612.
18) Cerella, Claudia, Mario Dicato, and Marc F. Diederich. "Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf..."
19) Girish, K., and Bhat S. Shankara. "Neem–a green treasure." Electronic journal of Biology 4.3 (2008): 102-111.
20) Rahmani, Arshad, et al. "Pharmacological and therapeutic potential of neem (Azadirachta indica)." Pharmacognosy Reviews 12.24 (2018): 250-255.
21) Mahadevan, N., and Pradeep Kamboj. "Hibiscus sabdariffa Linn.–an overview." (2009).
22) Sharma, Satish Kumar, and Suruchi Singh. "Antimicrobial herbal soap formulation." J. Pharmaceut. Res. Int 32.36 (2020): 82-88.
23) Mohamed, Bahaeldeen Babiker, Abdelatif Ahmed Sulaiman, and Abdelhafiz Adam Dahab. "Roselle (Hibiscus sabdariffa L.) in Sudan, cultivation and their uses." Bull. Environ. Pharmacol. Life Sci 1.6 (2012): 48-54.
24) El Bilali, Hamid. "State and contours of research on roselle (Hibiscus sabdariffa L.) in Africa." Open Agriculture 9.1 (2024): 20220336.
25) Almukashir, Mukhtar, et al. "Potent antibacterial activity of Terminalia chebula-based herbal soap formulation against Propionibacterium acnes and its cytotoxic evaluation on human skin fibroblast cells." Journal of Applied Pharmaceutical Research 11.5 (2023): 01-08.
26) Devi, A. Seetha, et al. "Formulation and Evaluation of Antimicrobial Herbal Soap." International Journal of Pharmaceutical Sciences Review and Research 71.2 (2021): 122-125.
27) Bhavani, J., et al. "FORMULATION AND EVALUATION OF HERBAL SOAP BY USING NATURAL INGREDIENTS." (2023).
28) Talreja, Shreya, Dr Tiwari, and Archana Bharti. "Formulation and evaluation of herbal soap by using moringa oleifera as main active constituents." European Chemical Bulletin 12 (2023): 2121-2141.
29) Gupta, Akash, et al. "Therapeutics role of neem and its bioactive constituents in disease prevention and treatment." Journal of Pharmacognosy and Phytochemistry 8.3 (2019): 680-691.
30) Kale, Mayuri, Anilkumar Aher, and Shraddha Dhanokar. "Authentication of Azadirachta indica (Neem) plant by pharmacognostic, physicochemical and phytochemical evaluation." Current Trends in Pharmacy and Pharmaceutical Chemistry 2.3 (2020): 109-115.
31) Singh, Varinder, et al. "An insight into the dermatological applications of neem: a review on traditional and modern aspect." Recent Advances in Anti-Infective Drug Discovery Formerly Recent Patents on Anti-Infective Drug Discovery 16.2 (2021): 94-121.
32) Kadir, Afreen, et al. "IN-DEPTH REVIEW ON TAXONOMY, PHYTOCHEMISTRY,
TRADITIONAL USES AND PHARMACOLOGICAL SIGNIFICANCE OF AZADIRACHTA INDICA PLANT." European Journal of Biomedical 11.6 (2024): 277-284.
33) Koul, A., et al. "Potential of Azadirachta indica against Salmonella typhimurium-induced inflammation in BALB/c mice." Inflammopharmacology 17 (2009): 29-36.
34) Eid, Ahmad, Nidal Jaradat, and Nagib Elmarzugi. "A Review of chemical constituents and traditional usage of Neem plant (Azadirachta Indica)." Palestinian Medical and Pharmaceutical Journal 2.2 (2017)
35) Hussein, M. E., et al. "Immunomodulatory and anti-inflammatory activities of the defatted alcoholic extract and mucilage of Hibiscus sabdariffa L. leaves, and their chemical characterization." Journal of Pharmacognosy and Phytochemistry 8.4 (2019): 982-990.
36) Gupta, Anshita, et al. "Exploration of anti-inflammatory activity of aquaeous extract of Hibiscus rosa sinesis (Malvacae)." Research Journal of Pharmacognosy and Phytochemistry 6.3 (2014): 109-111.
37) Guddeti, Venkateswarlu, et al. "EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF HIBISCUS ROSA SINENSIS Linn. FLOWER EXTRACT IN RATS." International Journal of Pharmaceutical, Chemical & Biological Sciences 5.3 (2015).
38) Mounika, B., and I. Bala Tripura Sundari. "Development and evaluation of anti-inflammatory activity of Hibiscus emulgel." International Journal of Ayurveda and herbal medicine 2 (2019): 3464-3476.
39) Sivaraman, Chinju M., and Fels Saju. "Medicinal value of Hibiscus rosa sinensis: a review." International Journal of Pharmacognosy and Chemistry (2021): 1-11.
40) Sultana, Sayema, et al. "In-vitro antiinflammatory, anti-oxidant and in-vivo analgesic, anti-diarrheal activities of fractional leaf extracts of Hibiscus surattensis." European Journal of Pharmaceutical and Medical Research 5.4 (2018): 167-173.
41) Patel, Shilpi, and Madhavi Adhav. "Comparative phytochemical screening of ethanolic extracts (flower and leaf) of morphotypes of Hibiscus Rosa-sinensis Linn." Journal of Pharmacognosy and Phytochemistry 5.3 (2016): 93-95.
42) Yakubu, Medinat Abbas, et al. "Chemical Constituents and Effect of Ethanol Leaf Extract of Hibiscus articulatus Hochst. ex A. Rich.(Malvaceae) on Glucose-and Streptozotocin-Induced Hyperglycaemia using Wistar Rats." Journal of Current Biomedical Research 2.5, September-October (2022): 503-532.
43) Sharma, S. A. F. A. L., et al. "Formulation And Evaluation of Herbal Soap Taking Different Bioactive Plants by Cold Saponification Method." Int J Curr Pharm Res 14.5 (2022): 30-35.
44) Aishwarya, Shinde, Kuskar Sharmila, and Kalyani Chande. "FORMULATION AND EVALUATION OF HERBAL SOAP." INNOVATIONS IN LIFE SCIENCES: 119.
45) Goukonde, Rekha, et al. "Formulation and evaluation of herbal scrub soap." World Journal of Biology Pharmacy and Health Sciences 18.3 (2024): 354-370.
46) Shah, Madeha, Zahida Parveen, and Muhammad Rashid Khan. "Evaluation of antioxidant, anti-inflammatory, analgesic and antipyretic activities of the stem bark of Sapindus mukorossi." BMC complementary and alternative medicine 17 (2017): 1-16.
47) Priyanka, M. "Herbal paper soap (Turmeric)."
48) Gorde, Shankar Vishnu, et al. "FORMULETION AND EVALUATION OF ALOE VERA SOAP." EPRA International Journal of Research and Development (IJRD) 9.5 (2024): 486-491.
49) Chou, Shun-Ting, et al. "Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation." Journal of ethnopharmacology 194 (2016): 617-625.
50) Sogo, Takayuki, et al. "Anti‐inflammatory activity and molecular mechanism of delphinidin 3‐sambubioside, a Hibiscus anthocyanin." BioFactors 41.1 (2015): 58-65.
51) Raduan, S. Z., et al. "Anti-inflammatory effects of Hibiscus rosa-sinensis L. and Hibiscus rosa-sinensis var. alba ethanol extracts." Int J Pharm Sci 5.4 (2013): 754-762.
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Dec 11, 2024
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Vandan Ghadiya, Vaidehi Gurjar, & Dr. Pragnesh Patani. (2024). HIBISCUS ROSA-SINENSIS AND AZADIRACHTA INDICA HEALING FOR GETTING SKIN INFLAMMATION NATURALLY: A REVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1046-1058. https://doi.org/10.53555/4rvj1z80
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Author Biographies
Vandan Ghadiya
Student, Khyati College of Pharmacy, Palodia, Ahmedabad.
Vaidehi Gurjar
Assistant Professor, Khyati College of Pharmacy, Palodia, Ahmedabad.
Dr. Pragnesh Patani
Principal, Khyati College of Pharmacy, Palodia, Ahmedabad.
How to Cite
Vandan Ghadiya, Vaidehi Gurjar, & Dr. Pragnesh Patani. (2024). HIBISCUS ROSA-SINENSIS AND AZADIRACHTA INDICA HEALING FOR GETTING SKIN INFLAMMATION NATURALLY: A REVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1046-1058. https://doi.org/10.53555/4rvj1z80