TRIGLYCERIDE-GLUCOSE INDEX: A NOVEL MARKER OF THE INSULIN RESISTANCE FOR THE PREDICTION OF DIABETIC NEPHROPATHY
Main Article Content
Keywords
Diabetic nephropathy, Insulin resistance, HDL, Type 2 diabetes mellitus, Triglyceride-glucose index
Abstract
This study aims at the identification of the relationship between insulin resistances (IR) in patients with type 2 diabetes mellitus (T2DM) and the triglyceride-glucose (TyG) index as determined by the homeostasis model assessment (HOMA-IR). Furthermore, the relationship between the TyG index and the urine albumin-to-creatinine ratio (UACR) was investigated in order to evaluate the TyG index's potential as a diagnostic for diabetic nephropathy.
Place and Duration of Study: This study was conducted in Bilawal Medical College Hospital Kotri From January 2023 to December 2023
Methodology
This was a cross-sectional study involving people recently diagnosed with T2DM. Vital signs, body mass index (BMI), age, gender, length of diabetes, and other clinical and demographic data were gathered. Important markers such as the UACR, TyG index, HOMA-IR, HbA1c, triglycerides, serum creatinine, and total cholesterol were assessed in the study. Based on their TyG index values, participants had been categorized into four quartiles: Q1=4.5–5, Q2=5.1–5.5, Q3=5.6–6, and Q4=>6. SPSS version 26 had been used to analyze the data.
Results
There were 200 participants in all, 130 of whom were female (65%) and 70 of whom were male (35%). The average age was 11.21 +/- 10.21 years. According to BMI classification, 75 (37.5%) had a normal BMI, 30 (15%) were obese, and 95 (47.5%) were overweight. In Q1, 80 (40%) in Q2, 40 (20%) in Q3, and 25 (12.5%) in Q4 was the quartile distribution. Higher levels of fasting glucose, total cholesterol, LDL cholesterol, triglycerides, HbA1c, HOMA-IR, and UACR were seen in Q4 participants (p<0.05). On the other hand, this group's eGFR and HDL levels were lower (p<0.05). TyG index (r=0.74, p<0.001), HOMA-IR (r=0.47, p<0.001), and UACR (r=0.11, p<0.05) all significantly correlated positively with HbA1c, but fasting serum insulin had an inverse relationship with both.
Conclusion
In people with T2DM, the TyG index was found as a good predictor of diabetic nephropathy because to its substantial connection with HOMA-IR. More research is necessary to determine its potential value as a clinical tool for nephropathy early identification.
References
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Kuldeep Kumar Poorani
Assistant professor of Medicine, Bilawal Medical College Lumhs Jamshoro, Pakistan.
Kashif Ali
Assistant professor of Medicine, Bilawal Medical College Lumhs Jamshoro, Pakistan
Bedar Bakhat Khan
Assistant professor of Medicine, LUMHS Jamshoro, Pakistan.
Atif Ahmed
Associate Professor of Medicine, Bilawal Medical College Lumhs Jamshoro, Pakistan
Kamran Ali Qureshi
Senior registrar Medicine, LUMHS Jamshoro, Pakistan.
Abdul Ghaffar Dars
Assistant professor of Medicine, LUMHS Jamshoro, Pakistan.