THE PROGNOSTIC VALUE OF THYROID FUNCTION TESTS IN ACUTE CORONARY SYNDROME: A COMPREHENSIVE STUDY IN AN INDIAN POPULATION
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Keywords
Thyroid dysfunction, Acute Coronary Syndrome, Thyroid Function Tests, Risk stratification, Prognostic value
Abstract
This research explores the prognostic significance of Thyroid Function Tests (TFTs) in patients diagnosed with Acute Coronary Syndrome (ACS) within an Indian demographic. Through a comprehensive evaluation of thyroid dysfunction in ACS patients, the study examines thyroid dysfunction in Acute Coronary Syndrome (ACS) patients in India. It found that 30% of patients had thyroid dysfunction, with 15% being hypothyroid and 10% hyperthyroid. Thyroid function tests (TFTs) positively correlated with ACS severity, while lower FT3 levels were associated with increased ACS severity. Thyroid dysfunction significantly impacted clinical outcomes, with higher TSH levels leading to longer hospital stays and higher mortality risk. Including TFTs in clinical models improved the prediction of major adverse cardiovascular events. ROC curve analysis showed that incorporating TFTs into clinical models improved the prediction of MACE, with the Area Under the Curve (AUC) increasing from 0.68 to 0.78 (p < 0.01), underscoring the utility of TFTs in enhancing risk stratification for ACS patients.
References
2. Yamakawa, T., S. Kato, J. Yuasa, et al. (2021). "Thyroid hormone plays an important role in cardiac function: from bench to bedside." Frontiers in Endocrinology.
3. Kumar, R., Sinha, R., Gunjan, G., & Singh, S. K. (2024). "A Cross-Sectional Study of Acute Coronary Syndrome and Thyroid Profile: Dissecting the Relationship to Improve Patient Care." Journal of Clinical Medicine.
4. Jabbar, L., Ingoe, H., Thomas, P., Carey, P., et al. (2021). "Prevalence, predictors, and outcomes of thyroid dysfunction in patients with acute myocardial infarction: the ThyrAMI-1 study." Endocrine Reviews.
5. Müller, P., Leow, M. K. S., & Dietrich, J. W. (2021). "Minor perturbations of thyroid homeostasis and major cardiovascular endpoints—Physiological mechanisms and clinical evidence." Journal of the American College of Cardiology.
6. Priyadarshini, Arambam., Shikhar, Gupta., Upendra, Kaul., Priya, Ranjan., Sudhir, Sekhawat., Rajiv, Janardhanan. Hypothyroidism in acute coronary syndrome – A prospective Indian study. Indian heart journal, (2024). doi: 10.1016/j.ihj.2023.12.008
7. E., M., Nifontov., I., S., Trusov., T., T., Khachikyan., A., V., Biryukov., Alexander, S., Krasichkov., D., S., Shapovalova., I., A., Serdiukovа. The influence of thyroid status on long-term complications after stenting in patients with acute coronary syndrome without ST-segment elevation.. Translational Medicine, (2024). doi: 10.18705/2311-4495-2023-10-6-484-494
8. Oğuz, Akkuş., Fatih, Şen., Ramazan, Yasdıbaş., Alper, Tunga, Ötegen., İrem, Hüzmeli., Gamze, Akkuş. Is Low-free Triiodothyronine (fT3) Associated with Increased Morbidity in Patients Admitted to Coronary Care Units?. Endocrine‚ Metabolic & Immune Disorders-Drug Targets, (2024). doi: 10.2174/0118715303287732240201122412
9. Bhavik, Thacker., Lalit, Shrimali., Abhishek, Padhiar. Evaluation of thyroid profile and its prognostic value in patients of acute coronary syndrome. Asian Journal of Pharmaceutical and Clinical Research, (2023). doi: 10.22159/ajpcr.2023.v16i10.47967
10. Yuan, Gao., Tianwei, Zhan., Yingchun, Xu., Kaijun, Zhu., Yifei, Shi., Langping, Jin., Liwei, Meng. Causal association of TSH with ischemic heart diseases and heart failure: A 2-sample Mendelian randomization study. Medicine, (2024). doi: 10.1097/md.0000000000037539
11. E., M., Nifontov., I., S., Trusov., T., T., Khachikyan., A., V., Biryukov., Alexander, S., Krasichkov., D., S., Shapovalova., I., A., Serdiukovа. The influence of thyroid status on long-term complications after stenting in patients with acute coronary syndrome without ST-segment elevation.. Translational Medicine, (2024). doi: 10.18705/2311-4495-2023-10-6-484-494
12. Shen, Wang., Yue, Wang., Shuaifeng, Sun., Fadong, Li., Wenxin, Zhao., Xinjian, Li., Maomao, Ye., Yufei, Niu., Xiaofan, Wu. Free triiodothyronine to free thyroxine ratio as a marker of poor prognosis in euthyroid patients with acute coronary syndrome and diabetes after percutaneous coronary intervention. Frontiers in Endocrinology, (2024). doi: 10.3389/fendo.2024.1322969
13. Bhavik, Thacker., Lalit, Shrimali., Abhishek, Padhiar. Evaluation of thyroid profile and its prognostic value in patients of acute coronary syndrome. Asian Journal of Pharmaceutical and Clinical Research, (2023). doi: 10.22159/ajpcr.2023.v16i10.47967
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Venkata Rao Vulli
Research Scholar, Department of Medical Biochemistry, Index Medical College Hospital and Research Centre, Indore
Dr. Shreya Nigoskar
Professor and head, Department of Medical Biochemistry, Index Medical College Hospital and Research Centre, Indore