“ASSESSMENT OF ISCHEMIA MODIFIED ALBUMIN AS A MARKER OF GLYCEMIA STATUS IN TYPE2 DIABETES MELLITUS PATIENTS”
Main Article Content
Keywords
Type 2 diabetes mellitus, hyperglycemia, hyperlipidemia, MDA and IMA.
Abstract
Background: The novel biomarker of ischemia and oxidative stress is called ischemia modified albumin (IMA). IMA has been linked to an increase in diabetes mellitus, according to numerous research. The metabolic disease known as diabetes mellitus (DM) is characterized by hyperglycemia, hypertension, and hyperlipidemia. Therefore, estimating the IMA levels in type 2 DM individuals was our goal. additionally to assess the correlation between IMA and every lipid profile measure (TC, LDL, HDL, TG) in individuals with type 2 diabetes.
Subjects and Methods: 200 subjects were selected from the medicine OPD of INDEX Medical College and Hospital for the study. Out of which 100 were diagnosed with T2DM and remaining 100 were age and sex matched healthy controls.
Results: Patients with type 2 diabetes had significantly higher levels of fasting and postprandial plasma glucose, HbA1c, serum TG, TC, LDL, HDL, and IMA compared to control participants (p <0.05). A noteworthy association was discovered between the IMA and the lipid profile.
Conclusion: According to the current study, IMA measurement in diabetic individuals with dyslipidemia can be an early indicator of ischemia and its severity. This might support improved DM management and prognosis.
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Dr. Pavan Kumar Sharma
Ph.D. Scholar, Department of Biochemistry, INDEX Medical College and Hospital, Indore, M.P.
Dr. Manoj Kumar Yadav
Associate Professor, Department of Biochemistry, World College of Medical Sciences Research and Hospital, Jhajjar
Dr. Shreya Nigoskar
Professor & Head, Department of Biochemistry, INDEX Medical College and Hospital, Indore, M.P.