"IMPACT OF ORAL ALOE VERA SUPPLEMENTATION ON DERMAL WOUND HEALING IN TYPE 2 DIABETIC RAT MODELS"

Abstract

The purpose of this research is to examine the role of oral Aloe Vera supplements on wound healing in rats to establish the efficiency and possible mechanisms. Utilizing a controlled experimental design, 40 rats were divided into two groups: an experimental control group that continued consuming a standard diet and an experimental treatment group that was given Aloe Vera at a dose of 200 mg/kg of the animal’s body weight for fourteen days. Healing of the wound was evaluated by monitoring the wounds daily for changes, measuring the size of the wound, and histological examination. Taking from the findings, it was observed that the Aloe Vera group showed an improvement in the wound healing ratio in comparison to the control group. More particularly, Aloe Vera group reduced their wound size by 35% after 7 days while the control group reduced it by 20%. The histopathological analysis revealed better results in the Aloe Vera group as regards establishment of more collagen (45%) and faster re-epithelialization (55%) than the control group with little inflammation (30%). Moreover, biochemical analysis showed increased superoxide dismutase in the Aloe Vera group, which indicates one of the ways by which the reduction of oxidative stress may have occurred. The outcomes here suggest that there is a marked expedite in wound healing and tissue repair by a supplementation of Aloe Vera in rat models. This work opens the door for further utilization of Aloe Vera as additional therapy for boosting the wound healing process and creates the need for further studies to unveil more of the beneficial aspects of Aloe Vera in wound care.