FETO MATERNAL OUTCOME IN DIABETIC MOTHER AND ITS ASSOCIATION WITH NEONATAL MORTALITY: A STUDY OF TERTIARY HOSPITAL OF PESHAWAR, KPK PAKISTAN

Main Article Content

Mahnaz Hanif
Syeda Wajeeha Ojala Shah
Neelam Hassan
Iman Adnan
Hoor Arif Kamal
Farhana Jabeen Shah

Keywords

Diabetes, Mortality, Newborn, Feto Maternal Outcome, Neonatal Mortality

Abstract

Introduction: The aim of the current study was to investigate the association between feto maternal outcome in diabetic mothers and its association with neonatal mortality in tertiary care hospital, Peshawar, Pakistan.


Methods: A retrospective cross-sectional research design was adopted in January 2024- June 2024. The population of the current study included all the mothers who were diagnosed with pre-existing diabetes who delivered at Hayatabad Medical Complex, Peshawar during the past 6 months. Data was collected from the medical records. A sample of 168 diabetic mothers, calculated through Cochran's formula, and their new newborns was collected through purposive sampling technique. Maternal Outcomes, including Mode of Delivery and Postpartum Hemorrhage (PPH), while Fetal Outcomes including Stillbirth, Meconium-Stained Liquor and Low APGAR Score was calculated. Demographics, descriptive, and Chi-square test was conducted for association between maternal diabetes and neonatal mortality  rates based on maternal diabetes characteristics. Analyses was done  through SPSS.


Results: The results indicated that 35.1% had type 1 diabetes and 64.9% had type 2 diabetes, indicating a predominant presence of type 2 diabetes in the study sample. Majority of diabetic mothers (47.6%) underwent normal delivery, while 37.5% required cesarean section, and 14.9% had instrumental delivery. Similarly, a total of 8.9% of mothers sustained genital tract trauma during delivery, indicating potential complications associated with childbirth. 8.9% of newborns of diabetic mothers were stillborn, indicating a significant risk factor associated with maternal diabetes. A low APGAR score (<8/10) was observed in 23.8% of newborns, highlighting potential neonatal health challenges at birth. The neonatal mortality  was 4.8%, indicating deaths among newborns within the first 28 days of life and  there was a significant association between maternal outcomes and neonatal mortality (Chi-Square = 6.21, p = 0.013).


Conclusion: According to the results of the current study, diabetes may have serious consequences for both mother and neonates therefore early diagnosis and treatment with dietary changes and use of oral hypoglycemic drugs or insulin are crucial. Pregnant women with pre-existing diabetes are more likely to have complications throughout their pregnancy,

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References

1. Anane-Fenin, B., et al., A ten-year review of indications and outcomes of obstetric admissions to an intensive care unit in a low-resource country. Plos one, 2021. 16(12): p. e0261974.
2. Bellos, I., A. Pandita, and R. Panza, Maternal and perinatal outcomes in pregnant women infected by SARS-CoV-2: A meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2021. 256: p. 194-204.
3. Ebrahimi, S., et al., A comparative study on adverse pregnancy outcomes in pregnant women with different age. Journal of Holistic Nursing And Midwifery, 2021. 31(1): p. 9-16.
4. Jung, Y.M., et al., Prognosis of remaining fetus in twin pregnancy after demise of one fetus according to its location. BMC Pregnancy and Childbirth, 2024. 24(1): p. 430.
5. Kimani, M.W., Association between third trimester cerebro-placental ratio and adverse outcomes in appropriate for gestational age foetuses. 2022.
6. LIMENIH, A.S., A. KIDANEMARIAM, and A.D. DURESSA, Outcome of induction and associated factors among induced laboring mother at Dessie Comprehensive specialized Hospital, Dessie, Ethiopia. 2024.
7. Magar, J.S., P.S. Rustagi, and A.D. Malde, Retrospective analysis of patients with severe maternal morbidity receiving anaesthesia services using'WHO near miss approach'and the applicability of maternal severity score as a predictor of maternal outcome. Indian Journal of Anaesthesia, 2020. 64(7): p. 585-593.
8. Si, K.-y., et al., Cesarean delivery on maternal request and common child health outcomes: A prospective cohort study in China. Journal of Global Health, 2022. 12.
9. Teka, H., et al., Clinical presentation, maternal-fetal, and neonatal outcomes of early-onset versus late onset preeclampsia-eclampsia syndrome in a teaching hospital in a low-resource setting: A retrospective cohort study. PloS one, 2023. 18(2): p. e0281952.
10. Yu, D.-Q., et al., Glycemic control and neonatal outcomes in women with gestational diabetes mellitus treated using glyburide, metformin, or insulin: a pairwise and network meta-analysis. BMC endocrine disorders, 2021. 21: p. 1-15.
11. Broni, E.K., et al., The diabetes-cardiovascular connection in women: understanding the known risks, outcomes, and implications for care. Current diabetes reports, 2022. 22(1): p. 11-25.
12. Chen, J., et al., Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs. PLoS medicine, 2020. 17(8): p. e1003305.
13. Li, M.-F., et al., Maternal pre-pregnancy obesity combined with abnormal glucose metabolism further increases adverse pregnancy outcomes in Chinese pregnant women. Frontiers in Endocrinology, 2022. 12: p. 754406.
14. Shen, Y., et al., Association of gestational diabetes mellitus with adverse pregnancy outcomes: our experience and meta-analysis. International Journal of Diabetes in Developing Countries, 2020. 40: p. 357-370.
15. Sheng, B., et al., Short-term neonatal outcomes in women with gestational diabetes treated using metformin versus insulin: a systematic review and meta-analysis of randomized controlled trials. Acta Diabetologica, 2023. 60(5): p. 595-608.
16. Tang, X., et al., Predelivery HbA1c levels and their relationship with adverse perinatal outcomes in women with normal 75-g OGTT. Archives of Gynecology and Obstetrics, 2023: p. 1-8.
17. Ugwu, A.O., et al., Maternal and Perinatal Outcomes of Preeclampsia at a Tertiary Hospital in Lagos, Nigeria. International Journal of Medicine and Health Development, 2022. 27(2): p. 197-200.
18. Vishwakarma, A., ASSOCIATION OF MATERNAL ABO BLOOD GROUP AND RANDOM BLOOD GLUCOSE LEVELS IN PATIENTS OF HYPERTENSIVE DISORDER OF PREGNANCY. 2022.
19. Wu, H., et al., Maternal age at birth and neonatal mortality: Associations from 67 low‐income and middle‐income countries. Paediatric and Perinatal Epidemiology, 2021. 35(3): p. 318-327.
20. Yin, B., et al., Maternal gestational weight gain and adverse pregnancy outcomes in non-diabetic women. Journal of Obstetrics and Gynaecology, 2023. 43(2): p. 2255010.
21. Awoyesuku, P.A., D.H. John, and L.B. Lebara, Maternal and perinatal outcome in severe preeclampsia and eclampsia at the Rivers State university teaching hospital, Nigeria. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2020. 9(11): p. 4383.
22. Behboudi-Gandevani, S., et al., The effect of mild gestational diabetes mellitus treatment on adverse pregnancy outcomes: A systemic review and meta-analysis. Frontiers in endocrinology, 2021. 12: p. 640004.
23. Carlsen, E.Ø., Determinants of perinatal outcomes in Norway: 1982-2020. 2023.
24. Greco, E., et al., Gestational diabetes mellitus and adverse maternal and perinatal outcomes in twin and singleton pregnancies: a systematic review and meta-analysis. American Journal of Obstetrics and Gynecology, 2023.
25. Lijalem, N., Maternal and fetal outcome of hypertension related pregnancy and their associated risk factors in Adigrat General Hospital, Northern Ethiopia, hospital based retrospective cohort study. 2020, Kamuzu University of Health Sciences.
26. Liu, X., et al., Associations between gestational weight gain and adverse birth outcomes: a population-based retrospective cohort study of 9 million mother-infant pairs. Frontiers in nutrition, 2022. 9: p. 811217.
27. Vasconcelos, A., et al., Adverse birth outcomes and associated factors among newborns delivered in Sao Tome & Principe: A case‒control study. Plos one, 2023. 18(7): p. e0276348.
28. Xu, Y., et al., Prevalence of major morbidities and outcome of all hospitalized neonates. A retrospective cohort study of Huai’an neonatal survivals. The Journal of Maternal-Fetal & Neonatal Medicine, 2022. 35(25): p. 9800-9810.
29. Ogumu, E.I., et al., Fetal and maternal outcome of higher-order multiple pregnancies in a tertiary hospital: A 5-year single-center observational study from Nigeria. SAGE Open Medicine, 2022. 10: p. 20503121221127160.