COMBINED EFFECT OF VITAMIN B (B6, B9, B12) AND POTASSIUM SUPPLEMENTATION ON STROKE IN RAT MODEL
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Keywords
Vitamin B, Complete Blood Count (CBC), Homocysteine Level, Liver Function Tests (LFTs), Potassium
Abstract
Stroke is second most common cause of death and the third most common cause of disability worldwide. The burden of stroke is rising quickly in low and middle-income nations, many of which are ill-equipped to handle the problem it poses. The objective of the current study was to determine the combined effect of Vitamin B (B6, B9, B12) and Potassium supplementation on stroke in rat model. Methods: Vitamin B (B6, B9, B12) and Potassium was bought in supplemented form. Rats were divided into five groups, including a control group Go). Complete Blood Count (CBC), Liver Function Test, Homocysteine Level and Blood Pressure were analyzed to check impact of B vitamins and potassium. The p-value <0.05 was considered significant. Results: Vitamin B (B6, B9, B12) and Potassium supplementations significantly decrease the Homocysteine level by 55% (19.95 ± 0.08 g/dL) and (21.97 ± 0.06 g/dL) respectively. The systolic and diastolic blood pressure significantly de-escalated with the potassium supplementation diastolic (84.96 ± 0.06 mmHg) and systolic (122.97 ± 0.06 mmHg) in (G4 group). Conclusion: Our findings suggest that Vitamin B (B6, B9, B12) and Potassium supplementation shod improving trend in the CBC, LFT, s Homocysteine levels and BP. Further research is warranted to explore the translational potential in human subjects.
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Noman Aslam
Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan
Muhammad Imran Hussain
Assistant Professor Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan
Khansa
Lecturer Al Razi Institute, Lahore
Imran Nawaz Bhatti
Minhaj University, Lahore
Qaswara Affaf
University of Veterinary & Animal Sciences, Lahore
Hafiza Iqra Akram
Government College University Faisalabad
Sahir Shahzad
Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan
Tasbiha Irfan
Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan
Moha Akram Khan
Department of Diet and Nutrition Sciences, Rashid Latif Khan University