SYNERGISTIC EFFECT OF ASCORBIC ACID AND IRON SUPPLEMENTATION AGAINST POSTPARTUM ANEMIA AND OXIDATIVE STRESS MITIGATION
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Keywords
PPA, Hb, Serum iron Level, Serum Ferritin Level, Serum vitamin C, MetHb%, TAC
Abstract
Background & Objective: Postpartum Anemia is a multi-factorial pathogenic condition, which is etiologically determined by decreased blood cells production and decline in antioxidant levels which fail to fulfill body requirements and result in severe health related complications such as postnatal iron deficiency, inflammation, defective erythropoiesis, hemolysis and oxidative stress. Vitamin C decreases oxidative stress as well as enhance absorption of iron from non heme sources and ultimately increases maternal iron stores by converting oxidation state of iron from (Fe3+) ferric iron to (Fe2+) ferrous iron. Aim of this study is; To determine the role of oxidative stress in denouement of anemia and combined effect of vitamin C along with iron supplementation during postpartum anemia on maternal iron status and oxidative stress.
Methods: RCT was conducted in THQ hospital Muridke, Pakistan .40 patients were included and data that was collected included Demographics, PBAC scoring, CBC, Serum iron, Serum Ferritin, Serum vitamin C, MetHb%, TAC and FFQ. Participants were then divided into 2 groups that were observed for 8 weeks. The control group received iron supplementation (iron poly maltose 100g) 1 tablet per day and experimental group received both iron and vitamin C supplementation (iron poly maltose 100g along with chewable vitamin C 500mg), 1 tablet of both supplements per day in a single dose for 8 weeks. After 8 weeks post analysis of above mentioned parameters was done.
Results: Hb, HCT, MCV and MCH level of experimental and control group was found significant (p=0.000 < 0.05). RBCs count in experimental and control group was not significant (P=O.610 >0.05).Results indicated no significant improvement in RBCs count with any supplement. However, Serum iron level, serum ferritin and serum vitamin c levels of experimental and control group was significant (p=0.000 < 0.05). Similarly, MetHb% and TAC level of both groups improved significantly (p=0.000<0.05).
Conclusion: Vitamin C and iron considerably shown pronounced improvement in Hb, HCT, MCV, MCH, Serum iron, TAC and Serum Ferritin levels and decreases MetHb% in women with postpartum anemia. But the improvement in RBCs count was not significant. Improved TAC level and decline in MetHb% after treatment indicate that vitamin c improves oxidantal defense within body.
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Khansa
Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan
Muhammad imran Hussain
Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan
Mubashra Basharat
Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan
Saba Akhtar
Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan
Munawara Mohamed Yahaya
Indira Gandhi National Open University, India
Noman Aslam
Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan
Sahir Shahzad
Department of Human Nutrition & Dietetics, Riphah International university QIE campus, Lahore, Pakistan