Enhancing Fasting Safety in Ramadan for Adults and Adolescents with Type 1 Diabetes Mellitus through Optimal Diabetes Care
Main Article Content
Keywords
Ramadan fasting, Type 1 Diabetes Mellitus, glycemic control
Abstract
Despite guidelines advising against fasting for individuals with type 1 diabetes during Ramadan, many choose to fast, posing risks of hypoglycemia, hyperglycemia, and diabetic ketoacidosis.
Aim: This study aimed to assess the effects of optimal care, including Ramadan-focused education, flash glucose monitoring, dietary advice, and treatment adjustment, on the safety of Ramadan fasting in individuals with type 1 diabetes.
Methods: Thirty participants with type 1 diabetes, opting to fast during Ramadan, were enrolled. Pre-Ramadan, all received specialized education and training for Freestyle Libre (FSL) sensor use. Participants utilized the sensor for 6 weeks (pre-Ramadan and during Ramadan). Physical and biological parameters were collected 2 to 4 weeks before and after Ramadan.
Results: Among the 24 patients on basal bolus insulin and 2 on insulin pumps with FSL data, the average fasting period was 24 days. Ninety-five percent reported educational session benefits. No clinically significant changes in physical/biological data occurred pre/post-Ramadan, except for a reduction in HbA1c from 8.2% to 7.9% post-Ramadan (P=0.010). While 63% adjusted insulin doses during Ramadan, flash glucose monitoring revealed fewer hypoglycemic episodes (29.2% vs. 46.7% pre-Ramadan). One case of diabetic ketoacidosis occurred due to missed insulin doses to prevent hypoglycemia.
Conclusion: Selective individuals with type 1 diabetes, receiving optimal care, demonstrated improved glycemic control and reduced hypoglycemia risk during Ramadan fasting. Larger, randomized controlled trials are necessary for generalizing these findings as recommendations.
References
2. Al-Arouj, M., Assaad-Khalil, S., Buse, J., Fahdil, I., Fahmy, M., Hafez, S., et al. (2010). Recommendations for management of diabetes during Ramadan: update 2010. Diabetes Care, 33(8), 1895-1902.
3. Abdelgadir, E. I., Hassan, K., Basheir, A. M., Afandi, B. O., Alawadi, F., et al. (2015). Comparison of Incidences, Hospital Stay and Precipitating Factors of Diabetic Ketoacidosis in Ramadan and the Following Month in Three Major Hospitals in United Arab Emirates. A Prospective Observational Study. J Diabetes Metab Disord, 6(514).
4. Abdelgadir, E. I., Hassanein, M. M., Bashier, A. M., Abdelaziz, S., Baki, S., Chadli, A., et al. (2016). A prospective multi-country observational trial to compare the incidences of. J Diabetes Metab Disord, 15, 50.
5. Salti, I., Benard, E. F., Detournay, B., Bianchi-Biscay, M., Le Brigand, C., et al. (2004). A population-based study of diabetes and its characteristics during the fasting. Diabetes Care, 27(10), 2306-2311.
6. Klonoff, D. C., Ahn, D., & Drincic, A. (2017). Continuous glucose monitoring: A review of the technology and clinical use. Diabetes Res Clin Pract, 133, 178-192. doi:10.1016/j.diabres.2017.08.005.
7. Poolsup, N., Suksomboon, N., & Kyaw, A. M. (2013). Systematic review and meta-analysis of the effectiveness of continuous glucose monitoring (CGM) on glucose control in diabetes. Diabetol Metab Syndr, 5, 39.
8. Langendam, M., Luijf, Y. M., Hooft, L., Devries, J. H., Mudde, A. H., & Scholten, R. J. (2012). Continuous glucose monitoring systems for type 1 diabetes mellitus. Cochrane Database Syst Rev, 1, CD008101.
9. Alamoudi, R., Alsubaiee, M., Alqarni, A., Saleh, Y., Aljaser, S., Salam, A., et al. (2017). Comparison of Insulin Pump Therapy and Multiple Daily Injections Insulin Regimen. Diabetes Technol Ther, 19(6), 349-354. doi:10.1089/dia.2016.0418.
10. Deeb, A., Al Qahtani, N., Attia, S., Al Suwaidi, H., & Nagelkerke, N. (2016). Does Reducing Basal Insulin During Ramadan Fasting by Children and Adolescents. Diabetes Technol Ther, 18(9), 539-542. doi:10.1089/dia.2016.0197.
11. Afandi, B., Kaplan, W., Al Hassani, N., Hadi, S., & Mohamed, A. (2017). Rate, timing, and severity of hypoglycemia in adolescents with type 1 diabetes during Ramadan fasting: A Study with FreeStyle Libre flash glucose monitoring system. Ibnosina J Med Biomed Sci, 10, 9-11.
12. Afandi, B., Kaplan, W., Al Hassani, N., Hadi, S., & Zoubeidi, T. (2017). Comparison of continuous glucose monitoring in adolescents with type 1 diabetes. Diabetes Res Clin Pract, 134, 178-182. doi:10.1016/j.diabres.2017.10.010.
13. Deeb, A., Al Qahtani, N., Akle, M., Singh, H., Assadi, R., Attia, S., et al. (2017). Attitude, complications, ability of fasting. Diabetes Res Clin Pract, 126, 10-15. doi:10.1016/j.diabres.2017.01.015.
14. Bravis, V., Hui, E., Salih, S., Mehar, S., Hassanein, M., & Devendra, D. (2010). Ramadan Education and Awareness in Diabetes (READ) programme for Muslims with Type 2 diabetes who fast during Ramadan. Diabet Med, 27(3), 327-331.
15. Mustafa, H., Hashim, T., Beshyah, S., Amin, R., Eissa, R., Tommy, M., et al. (2012). The Effect of “Targeted Diabetes Education” on Glycemic Control During Ramadan Fasting. 242-248.
16. Mohamed, O. HM., Syeed, A., Khan, F. B., Al Tunaiji, M. AMS., Ofiaelia, N. NEO., Al Bloushi, N., & Ali, N. MM. AHS., Lahloub, E. (2019). Impact of Pre-Ramadan Intervention Program on Diabetic Patients (PRINTED 1): A Randomised Controlled Trial in a Family Medicine Clinic - Abu Dhabi. World Family Medicine / Middle East Journal of Family Medicine, 17(1), 10-22.
17. Tourkmani, A. M., Hassali, M. A., Alharbi, T. J., Alkhashan, H. I., Alobikan, A. H., Bakhiet, A. H., et al. (2016). Impact of Ramadan focused education program on hypoglycemic risk and metabolic control for patients with type 2 diabetes. Patient preference and adherence, 10, 1709-1717.
18. El Toony, L. F., Hamad, D. A., & Omar, O. M. (2018). Outcome of focused pre-Ramadan education on metabolic and glycaemic parameters in patients with type 2 diabetes mellitus. Diabetes Metab Syndr, 12(5), 761-767.
19. Petrie, J., Peters, A., Bergenstal, R., Holl, R., Fleming, A., & Heinemann, L. (2017). Improving the Clinical Value and Utility of CGM Systems: Issues and Recommendations: A Joint Statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group.
20. Fokkert, M. J., van Dijk, P. R., Edens, M. A., Abbes, S., de Jong, D., Slingerland, R. J., et al. (2017). Performance of the FreeStyle Libre Flash glucose monitoring system in patients with type 1 and 2 diabetes mellitus. BMJ Open Diabetes Res Care, 5(1), e000320.