HISTOLOGICAL FINDINGS ON FORMULATION AND STABILITY OF AA-21 IN ALOPECIA ON CHEMOTHERAPY INDUCED ALOPECIA MODEL OF RAT.
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Keywords
Animal Model, Chemotherapy, Alopecia
Abstract
Introduction: Hair is the human body’s major esthetic display part, especially in cultural and social interactions. Hair serves many vital functions which includes defense from contaminants and sweat-gland dispersion substances e.g. pheromones. Alopecia is a common term for loss of hair, the hair matrix comprised (inside and outside) medulla, cortex and hair cuticle. The inner root sheath composed of the cuticle of the inner root sheath, the sheet of Huxley and the sheet of Henley (inside to out). The occurrence of hair loss is reported to increase gradually with increasing age in each of these males and females in populous-based surveys of White people aged 20-70 aged.
Methodology: This pre-clinical animal study was performed on wistar albino rats at animal house of faculty of pharmacy Ziauddin University Karachi. The duration of this study was eight to ten months. The successful induction of Alopecia was done, the animals were divided into three groups with six animals per group and all the CIA wistar rats were tested for effects of AA-21 on Alopecia as topical formulations and H&E was performed and our
Results were satisfactory.
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Shumaila Shaikh
Department of Pharmacology, Bibi Aseefa Dental College, larkana, Sindh Pakistan.
Sadaf Ibrahim
Department of Pharmacology, Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan.
Mirza Tasawer Baig
Department of Pharmacy Practice, Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan.
Aneela Atta Ur Rahman
Department of Community Medicine and Public Health Sciences at LUMHS, Jamshoro, Sindh, Pakistan.