TO ASSESS THE EFFICACY OF NAPROXEN AND SULFASALAZINE IN SUBJECTS WITH JUVENILE ONSET ANKYLOSING SPONDYLITIS (10-17 YEARS): A PROSPECTIVE STUDY
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Keywords
Juvenile onset of Ankylosing spondylitis, inflammatory markers, Sulfasalazine, Naproxen
Abstract
Background – Juvenile onset Ankylosing Spondylitis(JoAS) damages joints, inflames the spine, breaks bones, and causes back pain. Our study's objective was to evaluate the development of JoAS symptoms utilizing sophisticated inflammatory indicators.
Materials and methods: For this prospective study, three groups of 21 JOAS participants were created. Three men and two women made up Group A. There were four males and four females in each of the two groups, Group B and Group C. A placebo was given to Group A, 1000 mg of naproxen was given to Group B each day, and 2000 mg of sulfasalazine was given to Group C each day. BASFI, BASDAI, and BASGI scores of four were accepted by the study. JoAS was also connected to MMP-3, ICAM-1, IL-6, IL-17, TNF α, and IL-6. JoAS biomarker measures were taken at baseline and at six weeks in Groups A, B, and C. The levels of CRP, TNF α, IL-6, and MMP-3 in groups A, B, and C were compared.
Results - For TNF α -, IL-6, and MMP-3, the medication response was significantly greater in group C than in group B. IL-6 levels declined threefold in group C from baseline (p = 0.01) to the 6th week (p = 0.001). TNF α levels in groups B and C were lower than in group A. (p 0.01, p 0.001).
Conclusion IL-6 and TNF α are cytokines that may have a role in the immunopathogenesis of JoAS. We also believe that these cytokines can be utilized to make diagnoses and gauge the success of treatments. Sulfasalazine treats JoAS better than naproxen.
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Bansal Yogesh
Assistant Professor, Department of Biochemistry, Rajshree Medical Research Institute, Bareilly, Uttar Pradesh, India.