Antidiabetic activity of selenium nanoparticle synthesized using clove and cumin formulation
Main Article Content
Keywords
clove, cumin, anti diabetic, selenium synthesis, nanoparticles
Abstract
Background: Nanotechnology explores a lot of interesting approaches in the field of biomedicine. Researchers have recently developed interest in biomolecule mediated nanoparticle production because of its eco-friendly and non-toxic properties. Clova and cumin have long been used in traditional medicine to treat various illnesses.
Aim: The purpose of this study is to use clove and cumin extract to produce the selenium nanoparticles via green approach.
Materials And Method: Collection of clove and cumin extract then 1 g of clove and cumin, powder was dissolved in distilled water and boiled for 5–10 min at 60–70C. The solutions were then filtered using Whatman No. 1 filter paper. The filtered extract was collected, synthesis of selenium nanoparticles using an herbal formulation, and to finalise the anti- diabetic activity of silver nanoparticles.
Results: The antioxidant effect of selenium nanoparticles showed a higher percentage of inhibition at 50μg/ml in DPPH Assay and H2O2 Assay. The clove and cumin extract showed an increased percentage of inhibition with increasing concentration.
Conclusion: The clove and cumin formulation mediated selenium nanoparticles acts as potent antioxidant agents. It also has the least side effects compared to commercial drugs.
References
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15. Ms. K. Esha Gayathri, Dr. Lakshmi Thangavelu, Dr. Rajeshkumar Shanmugam, Dr. Elumalai Perumal*, Green synthesis of cumin and clove mediated selenium nanoparticles and its anticancer activity against osteosarcoma cell line, Journal of Survey in Fisheries Sciences, 2023, 10(1S) 300-311.
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18. Divij Khullar, S Rajeshkumar, Nabeel AhmedPhyto-assisted Synthesis and Assessment of Properties of Selenium Nanoparticles prepared Using Banana Stem Extracts and Incorporating them in a Mouthwash-A Patent, J Res Med Dent Sci, 2022, 10(1): 480-483.
19. M. Nagalingam, S. Rajeshkumar, Satheesh Kumar Balu, M. Tharani, Kalirajan Arunachalam, "Anticancer and Antioxidant Activity of Morinda Citrifolia Leaf Mediated Selenium Nanoparticles", Journal of Nanomaterials, vol. 2022, Article ID 2155772, 7 pages, 2022. https://doi.org/10.1155/2022/2155772
20. Shanmugam Rajeshkumar, Lakshmanan Ganesh, and Jayakodi Santhoshkumar, Selenium Nanoparticles as Therapeutic Agents in Neurodegenerative Diseases 978-3-030-30929-9 book entitled Nanobiotechnology in Neurodegenerative Diseases Mahendra Rai· Alka Yadav –Editors, ISBN 978-3-030-30929-9 ISBN 978-3-030-30930-5 (eBook), https://doi.org/10.1007/978-3-030-30930-5.pp-209-224
21. Soumya Menon, Shrudhi Devi KS, Santhiya R, Rajeshkumar S, Venkat Kumar S, Selenium nanoparticles: A potent chemotherapeutic agent and an elucidation of its mechanism, Colloids and Surfaces B: Biointerfaces (2018) 1;170:280-92. https://doi.org/10.1016/j.colsurfb.2018.06.006.
2. Afshari, M., Pazoki, A., & Sadeghipour, O. (2022). Biochemical changes of coriander ( Coriandrum sativum L. ) plants under drought stress and foliar application of salicylic acid and silicon nanoparticlesJournal of Medicinal Plants and By-Products https://doi.org/10.47363/jftns/2021(3)124
3. Adibzadeh, P., & Motakef-kazemi, N. (2018). Preparation and characterization of curcumin-silver nanoparticle and evaluation of the effect of poly ethylene glycol and temperatureJournal of Nanoanalysishttps://doi.org/10.1016/j.lwt.2016.11.051
4. Abdelsalam, N. R., Fouda, M. M. G., Abdel-Megeed, A., Ajarem, J., Allam, A. A., & El-Naggar, M. E. (2019). Assessment of silver nanoparticles decorated starch and commercial zinc nanoparticles with respect to their genotoxicity on onionInternational Journal of Biological Macromolecules. https://doi.org/10.1016/S0367-326X(02)00235-6
5. Abdellah, A. M., Sliem, M. A., Bakr, M., & Amin, R. M. (2018). Green synthesis and biological activity of silver-curcumin nanoconjugatesFuture Medicinal Chemistry, 10(22), 2577–2588https://doi.org/10.4155/fmc-2018-0152
6. Abbassi, A., Mahmoudi, H., Zaouali, W., M’Rabet, Y., Casabianca, H., & Hosni, K. (2018). Enzyme-aided release of bioactive compounds from coriander (Coriandrum sativum L.) seeds and their residue by-products and evaluation of their antioxidant activityJournal of Food Science and Technology, 55(8), 3065–3076https://doi.org/10.1007/s13197-018-3229-4
7. Ahmed, B., Shahid, M., Khan, M. S., & Musarrat, J. (2018). Chromosomal aberrations, cell suppression and oxidative stress generation induced by metal oxide nanoparticles in onion (Allium cepa) bulbMetallomics, 10(9), 1315–1327https://doi.org/10.1039/c8mt00093j
8. Al-Ghamdi, A. Y. (2019). Antimicrobial and catalytic activities of green synthesized silver
nanoparticles using bay laurel (Laurus nobilis) leaves extractJournal of Biomaterials and Nanobiotechnology, 10(01), 26–39https://doi.org/10.4236/jbnb.2019.10100
9. Al-Saif, S. S. A. L., Awad, M. A., & Siddiqui, M. I. (2018). Formation, characterization and pathogen activities of green synthesis of curcuma silver nanoparticlesJournal of Computational and Theoretical Nanoscience, 15(4), 1300–1306https://doi.org/10.1166/jctn.2018.7306
10. Alghuthaymi, M. A., Diab, A. M., Elzahy, A. F., Mazrou, K. E., Tayel, A. A., & Moussa, S. H. (2021). Green biosynthesized selenium nanoparticles by cinnamon extract and their antimicrobial activity and application as edible coatings with nano-chitosanJournal of Food Quality, 2021https://doi.org/10.1155/2021/6670709
11. Alhumaydhi, F. A., Khan, I., Rauf, A., Qureshi, M. N., Aljohani, A. S. M., Khan, S. A., Khalil, A. A., El-Esawi, M. A., & Muhammad, N. (2021). Synthesis, characterization, biological activities, and catalytic applications of alcoholic extract of saffron (Crocus sativus) flower stigma-based gold nanoparticlesGreen Processing and Synthesis, 10(1), 230–245https://doi.org/10.1515/gps-2021-0024
12. Alquraidi, A. O., Mosa, K. A., & Ramamoorthy, K. (2019). Phytotoxic and genotoxic effects of copper nanoparticles in coriander (Coriandrum sativum—apiaceae)Plants, 8(1), 19https://doi.org/10.3390/plants8010019
13. Katyal, D., Jain, R.K. and Rajeshkumar, S., Evaluation Of Cytotoxicity Of A Novel Mouthwash Containing Selenium Nanoparticles And Chitosan Colloid. Eur. Chem. Bull. 2023, 12 (S2), 156 – 163. DOI: 10.31838/ecb/2023.12.s2.019
14. Ms. Priyadharshni. Dr. R, Lakshmi Thangavelu, Dr. Rajeshkumar Shanmugam, Dr. Elumalai Perumal, Anticancer Activity Of Selenium Nanoparticles Synthesis Using Clove And Cumin Against Colon Cancer Cell Line, Journal of Survey in Fisheries Sciences, 2023, 10(1S) 243-252.
15. Ms. K. Esha Gayathri, Dr. Lakshmi Thangavelu, Dr. Rajeshkumar Shanmugam, Dr. Elumalai Perumal*, Green synthesis of cumin and clove mediated selenium nanoparticles and its anticancer activity against osteosarcoma cell line, Journal of Survey in Fisheries Sciences, 2023, 10(1S) 300-311.
16. Indumathi M, S Rajeshkumar, D Ezhilarasan, Lakshmi.T, Biosynthesis of Selenium Nanoparticles using Ficus benghalensis and its Oral Pathogen Control, International Journal ofEarly Childhood Special Education Vol 14, Issue 03 2022,3339-3350
17. Pandiyan I, SriS, Indiran MA, Rathinavelu PK, Prabakar J, Rajeshkumar S. Antioxidant, anti-inflammatory activity of Thymus vulgaris-mediated selenium nanoparticles: An in vitro study. J Conserv Dent 2022;25:241-5. https://www.jcd.org.in/text.asp?2022/25/3/241/347343.
18. Divij Khullar, S Rajeshkumar, Nabeel AhmedPhyto-assisted Synthesis and Assessment of Properties of Selenium Nanoparticles prepared Using Banana Stem Extracts and Incorporating them in a Mouthwash-A Patent, J Res Med Dent Sci, 2022, 10(1): 480-483.
19. M. Nagalingam, S. Rajeshkumar, Satheesh Kumar Balu, M. Tharani, Kalirajan Arunachalam, "Anticancer and Antioxidant Activity of Morinda Citrifolia Leaf Mediated Selenium Nanoparticles", Journal of Nanomaterials, vol. 2022, Article ID 2155772, 7 pages, 2022. https://doi.org/10.1155/2022/2155772
20. Shanmugam Rajeshkumar, Lakshmanan Ganesh, and Jayakodi Santhoshkumar, Selenium Nanoparticles as Therapeutic Agents in Neurodegenerative Diseases 978-3-030-30929-9 book entitled Nanobiotechnology in Neurodegenerative Diseases Mahendra Rai· Alka Yadav –Editors, ISBN 978-3-030-30929-9 ISBN 978-3-030-30930-5 (eBook), https://doi.org/10.1007/978-3-030-30930-5.pp-209-224
21. Soumya Menon, Shrudhi Devi KS, Santhiya R, Rajeshkumar S, Venkat Kumar S, Selenium nanoparticles: A potent chemotherapeutic agent and an elucidation of its mechanism, Colloids and Surfaces B: Biointerfaces (2018) 1;170:280-92. https://doi.org/10.1016/j.colsurfb.2018.06.006.
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Published
Jun 1, 2023
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How to Cite
A.Ruhina hussaini, S Rajeshkumar, & T Lakshmi. (2023). Antidiabetic activity of selenium nanoparticle synthesized using clove and cumin formulation. Journal of Population Therapeutics and Clinical Pharmacology, 30(13), 130-135. https://doi.org/10.47750/jptcp.2023.30.13.013
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
A.Ruhina hussaini, S Rajeshkumar, & T Lakshmi. (2023). Antidiabetic activity of selenium nanoparticle synthesized using clove and cumin formulation. Journal of Population Therapeutics and Clinical Pharmacology, 30(13), 130-135. https://doi.org/10.47750/jptcp.2023.30.13.013