“UNRAVELING THE GENETIC AND ENVIRONMENTAL LINK BETWEEN OBESITY AND DIABETES: STUDY TO IDENTIFYING METABOLIC BIOMARKERS FOR EARLY DETECTION OF OBESITY AND TYPE 2 DIABETES”
Main Article Content
Keywords
Obesity, Diabetes Mellitus, Genetic factors, Public health, Environmental factors
Abstract
Introduction:
Obesity and diabetes mellitus are two interconnected health conditions that have reached epidemic proportions worldwide. Obesity and diabetes mellitus (DM) represent two intertwined public health crises of the modern era. While environmental factors like diet and physical activity are pivotal, genetic predisposition also plays a significant role in the development of these conditions.
Objective:
- To examine the genetic and environmental factors associated with obesity and diabetes.
- To identify biochemical and clinical markers for early detection of these conditions.
Material and Methods: This cross-sectional study investigates the genetic, environmental, biochemical, and clinical factors linking obesity and DM. Data were collected from a representative sample of 300 individuals to identify key genetic markers, environmental influences, early metabolic biomarkers, clinical parameters and metabolomic markers associated with these conditions.
Results: There were 300 participants who included in this research after inclusion and exclusion criteria in which 25 were male and 35 were females with mean age 40 as obesity is concerned. The non obese persons include 40 were males and 50 females with mean age 37. The diabetic labeled persons include 40 each male and females with mean age 42 and non diabetic include 45 males and 25 were females with mean age 39. The other parameters include biochemical, clinical, environmental and metablomic showing significant results.
Conclusion: In conclusion, this review highlights the complex interplay between genetic, environmental, and lifestyle factors contributing to the development of obesity and diabetes mellitus. The findings of this review demonstrate significant health disparities between individuals with obesity and diabetes mellitus and non-obese and non-diabetic individuals, emphasizing the need for early intervention, personalized medicine approaches, and further research.
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Tariq Attique
Senior Registrar, Department of Medicine, FPGMI, Shaikh Zayed Hospital, Lahore
Rizwan Zafar Ahmad
Professor & Head of Department, Medical Unit 2, Akhtar Saeed Medical and Dental College, Farooq Hospital, Lahore
Shazia
Assistant Professor, Department of Pulmonology, Rawal Institute of Health Sciences, Islamabad
Asifa Karamat
Associate Professor, Department of Pulmonology, Al Aleem Medical College, Gulab Devi Teaching Hospital, Lahore
Abdur Rahman Zaheer
Senior Registrar, Department of Pulmonology, Al Aleem Medical College, Gulab Devi Teaching Hospital, Lahore
Amna Riaz
Assistant Professor & Head Department of Endocrinology, Al Aleem Medical College, Gulab Devi Teaching Hospital, Lahore