INTEGRATIVE ANALYSIS OF OXIDATIVE STRESS, HORMONAL DYSREGULATION, AND BIOMARKER PROFILES IN METABOLIC DISORDERS: A CASE-CONTROL STUDY

Abstract

Metabolic disorders, a growing global health challenge, are intricately linked to oxidative stress and hormonal dysregulation. Compared to healthy controls, this study investigates the interplay between oxidative stress markers, hormonal profiles, and novel biomarkers in individuals with metabolic disorders. Utilizing a robust case-control design, this study included 200 participants (100 cases and 100 controls) recruited based on strict inclusion criteria. Oxidative stress parameters were analyzed, including malondialdehyde (MDA) and total antioxidant capacity (TAC), alongside hormonal markers such as insulin, cortisol, and adiponectin.
Results demonstrated significantly elevated MDA levels (p<0.001) and reduced TAC levels (p<0.05) in cases compared to controls, indicating heightened oxidative stress. Hormonal profiling revealed a marked dysregulation in insulin (p<0.001) and cortisol (p<0.01) levels, coupled with diminished adiponectin concentrations (p<0.05). Biomarker analysis highlighted emerging markers with significant potential for clinical application. This study's findings underscore the multifaceted nature of metabolic disorders, offering novel insights into the biomolecular underpinnings. These results contribute to understanding the etiopathogenesis and identify potential targets for early intervention