NAVIGATING THE CHALLENGES AND CONTROVERSIES IN SUNSCREEN: A REVIEW
Main Article Content
Keywords
Sunscreen, UV filters, toxicity, oxybenzone, octinoxate, safety
Abstract
This article explores the controversies and challenges associated with sunscreen use, focusing on the toxicity of UV filters. Sunscreens are critical in protecting against skin cancer and UV-related skin damage, yet certain chemical UV filters, such as oxybenzone and octinoxate, have raised significant health and environmental concerns. These concerns include potential endocrine disruption, allergic reactions, and the harmful impact on marine ecosystems, leading to regulatory bans in some regions. While physical UV filters like zinc oxide and titanium dioxide are generally considered safer, their nanoparticle forms warrant further investigation. The article also examines the role of regulatory bodies in reassessing the safety of these compounds and highlights consumer-driven demand for safer, more sustainable sunscreen options. By reviewing recent research and industry innovations, this article provides a comprehensive overview of the ongoing efforts to balance effective sun protection with the need to minimize risks to human health. The findings underscore the importance of continued research, regulatory oversight, and industry innovation in advancing safer sunscreen formulations that protect both our skin and the planet.
References
1. Guan, Linna L et al. “Sunscreens and Photoaging: A Review of Current Literature.” American journal of clinical dermatology 22,6 2021: 819-828.
2. Suh, Susie et al. “The banned sunscreen ingredients and their impact on human health: a systematic review.” International journal of dermatology vol. 59,9 2020
3. Adler, B.L., DeLeo, V.A. “Sunscreen Safety: a Review of Recent Studies on Humans and the Environment.” Curr Derm Rep 9, 1–9 2020
4. Matta MK, Florian J, Zusterzeel R, et al. “Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical Trial.” JAMA. 2020;323(3):256-267.
5. Suh, Susie et al. “The banned sunscreen ingredients and their impact on human health: a systematic review.” International journal of dermatology vol. 59,9 2020
6. Adler, B.L., DeLeo, V.A. “Sunscreen Safety: a Review of Recent Studies on Humans and the Environment.” Curr Derm Rep 9, 1–9 2020
7. "National Academies of Sciences, Engineering, and Medicine. Review of Fate, Exposure, and Effects of Sunscreens in Aquatic Environments and Implications for Sunscreen Usage and Human Health. Washington, DC: The National Academies Press. 2022
8. Khan, Maryam, Alim Husain Naqvi, and Masood Ahmad. "Comparative study of the cytotoxic and genotoxic potentials of zinc oxide and titanium dioxide nanoparticles." Toxicology reports 2 2015: 765-774.
9. A.C. Green, G.M. Williams, V. Logan, G.M. Strutton, “Reduced melanoma after regular sunscreen use: randomized trial follow-up”, J. Clin. Oncol. 29 (3) 2011
10. J.A. Ruszkiewicz, A. Pinkas, B. Ferrer, T.V. Peres, A. Tsatsakis, M. Aschner, “Neurotoxic effect of active ingredients in sunscreen products, a contemporary review”, Toxicol. Rep. 4 2017 245–259
11. Kockler, J.; Oelgemöller, M.; Robertson, S.; Glass, B.D. “Photostability of sunscreens.” J. Photochem. Photobiol. C Photochem. Rev. 2012, 13, 91–110.
12. Valle-Sistac, J.; Molins-Delgado, D.; Díaz, M.; Ibáñez, L.; Barceló, D.; Silvia Díaz-Cruz, M. “Determination of parabens and benzophenone-type UV filters in human placenta: First description of the existence of benzyl paraben and benzophenone-4.” Environ. Int. 2016, 88, 243–249.
13. Rehfeld, A.; Egeberg, D.L.; Almstrup, K.; Petersen, J.H.; Dissing, S.; Skakkebæk, N.E. EDC IMPACT: “Chemical UV filters can affect human sperm function in a progesterone-like manner.” Endocr. Connect. 2018, 7, 16–25.
14. López-Hera, D. “Medicina de Familia en la Red. Cremas Para el Sol Seguras: Como Elegir Fotoprotectores Solares No Tóxicos y Respetuosos Con El Medio Ambiente.” Available online: accessed on 1 September 2022
15. Kiriiri Geoffrey, A.N. Mwangi, S.M. Maru,Sunscreen products: Rationale for use, formulation development and regulatory considerations, Saudi Pharmaceutical Journal,Volume 27, Issue 7,2019,1009-1018,
16. Santander Ballestín, Sonia, and María José Luesma Bartolomé. "Toxicity of Different Chemical Components in Sun Cream Filters and Their Impact on Human Health: A Review" Applied Sciences 13, no. 2: 712. 2023
17. Skotarczak, K.; Osmola-Mańkowska, A.; Lodyga, M.; Polańska, A.; Mazur, M.; Adamski, Z. “Photoprotection: Facts and controversies.” Eur. Rev. Med. Pharmacol. Sci. 2015, 19, 98–112.
18. Narbutt, J. “Does the use of protective creams with UV filters inhibit the synthesis of vitamin D?”—For and against. Prz. Pediatry 2009, 41, 75–81.
19. Yeager, D.G.; Lim, H.W. “What’s new in photoprotection: A review of new concepts and controversies.” Dermatol. Clin. 2019, 37, 149–157.
20. Wang, S.Q.; Balagula, Y.; Osterwalder, U. “Photoprotection: A review of the current and future technologies.” Dermatol. Ther. 2010, 23, 31–47.
21. De Gruijl, F.R.; van Kranen, H.J.; Mullenders, L.H. “UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer.” J. Photochem. Photobiol. B 2001, 63, 19–27.
22. Liu, F.C.; Grimsrud, T.K.; Veierød, M.B.; Robsahm, T.E.; Ghiasvand, R.; Babigumira, R.; Shala, N.K.; Stenehjem, J.S. “Ultraviolet radiation and risk of cutaneous melanoma and squamous cell carcinoma in males and females in the Norwegian Offshore Petroleum Workers cohort.” Am. J. Ind. Med. 2021, 64, 496–510.
23. Duro Mota, E.; Campillos Páez, M.T.; “Causín Serrano, S. El sol y los filtros solares.” Medifam 2003, 13, 39–45.
24. Cole, C.; Shyr, T.; Ou-Yang, H. “Metal Oxide Sunscreens Protect Skin by Absorption, Not by Reflection or Scattering.” Photodermatol. Photoimmunol. Photomed. 2016, 32, 5–10.
25. Kollias, N. “The absorption properties of “physical” sunscreens.” Arch. Dermatol. 1999, 135, 209–210.
26. Garrote, A.; Bonet, R. Fotoprotección. Factores de protección y filtros solares. Offarm 2008, 27, 63–73.
27. Food and Drug Administration (US). “CFR—Code of Federal Regulations Title 21”; 2017, FDA Approved UV Filters for Sunscreens. online: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr
28. FDA Advances New Proposed Regulation to Make Sure That Sunscreens are Safe and Effective. Federal Register 84FR6204, 2019-03019. 2019. Available online: https://www.fda.gov/news-events/press-announcements/fda-advances-new-proposed-regulation-make-sure-sunscreens-are-safe-and-effective
29. Danovaro, R.; Bongiorni, L.; Corinaldesi, C.; Giovannelli, D.; Damiani, E.; Astolfi, P.; Greci, L.; Pusceddu, A. “Sunscreens cause coral bleaching by promoting viral infections.” Environ. Health Perspect. 2008, 116, 441–447.
30. Watkins, Y.S.D.; Sallach, J.B. “Investigating the exposure and impact of chemical UV filters on coral reef ecosystems: Review and research gap prioritization.” Integr. Environ. Assess Manag. 2021, 17, 967–981.
31. National Institute of Health 2020. “Endocrine Disruptors.” Available online: https://www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm
32. Environmental Protection Agency (US). Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and in Topical Sunscreen (Final). EPA/600/R-09/057F. 2010. Available online: https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=230972
33. Environmental Protection Agency (US). Endocrine Disruptor Screening Program. 2010. Available online: https://www.epa.gov/endocrine-disruption
34. “OECD.” Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption; OECD Publishing: Paris, France, 2018.
35. DeLeo, V. “Sunscreen.” In Bolognia J. Dermatology; Elsevier: London, UK, 2012; 2197–2204.
36. Garnacho Saucedo, G.M.; Salido Vallejo, R.; Moreno Giménez, J.C. “Effects of solar radiation and an update on photoprotection.” An. Pediatr. 2020, 92, 377.
37. Maier, T.; Korting, H.C. “Sunscreens—Which and what for?” Skin Pharm. Physiol. 2005, 18, 253–262.
38. Heneweer, M.; Muusse, M.; van den Berg, M.; Sanderson, J.T. “Additive estrogenic effects of mixtures of frequently used UV filters on pS2-gene transcription in MCF-7 cells.” Toxicol. Appl. Pharmacol. 2005, 208, 170–177.
39. Schlumpf, M.; Cotton, B.; Conscience, M.; Hailer, V.; Steinmann, B.; Lichtensteiger, W. “In vitro and in vivo estrogenicity of UV screens. “Environ. Health Perspect. 2001, 109, 239–244.
40. Coronado, M.; De Haro, H.; Deng, X.; Rempel, M.A.; Lavado, R. “Estrogenic activity and reproductive effects of the UV-filter oxybenzone (2-hydroxy-4-methoxyphenyl-methanone) in fish.” Aquat. Toxicol. 2008, 90, 182–187.
41. Krause, M.; Klit, A.; Blomberg Jensen, M.; Søeborg, T.; Frederiksen, H.; Schlumpf, M.; Lichtensteiger, W.; Skakkebaek, N.E.; Drzewiecki, K.T. “Sunscreens: Are they beneficial for health? An overview of endocrine disrupting properties of UV-Filters.” Int. J. Androl. 2012, 35, 424–436.
42. Broniowska, Z.; Slusarczyk, J.; Starek-Swiechowicz, B.; Trojan, E.; Pomierny, B.; Krzyzanowska, W.; Basta-Kaim, A.; Budziszewska, B. “The effect of dermal benzophenone-2 administration on immune system activity, hypothalamic-pituitary-thyroid axis activity and hematological parameters in male Wistar rats.” Toxicology 2018, 1, 1–8.
43. Krzyzanowska, W.; Pomierny, B.; Starek-Swiechowicz, B.; Broniowska, Ż.; Strach, B.; Budziszewska, B. “The effects of benzophenone-3 on apoptosis and the expression of sex hormone receptors in the frontal cortex and hippocampus of rats.” Toxicol. Lett. 2018, 296, 63–72.
44. Schreurs, R.; Lanser, P.; Seinen, W.; van der Burg, B. “Estrogenic activity of UV filters determined by an in vitro reporter gene assay and an in vivo transgenic zebrafish assay.” Arch. Toxicol. 2002, 76, 257–261.
45. Akhiyat, S.; Olasz-Harken, E.B. “Update on human safety and the environmental impact of physical and chemical sunscreen filters: What do we know about the effects of these commonly used and important molecules?” Pract. Dermatol. 2019,48–51. Available online: https://practicaldermatology.com/articles/201
46. Klimova, Z.; Hojerova, J.; Beránkova, M. “Skin absorption and human exposure estimation of three widely discussed UV filters in sunscreens–In vitro study mimicking real-life consumer habits.” Food Chem. Toxicol. 2015, 83, 237–250.
47. Joensen, U.N.; Jorgensen, N.; Thyssen, J.P.; Petersen, J.H.; Szecsi, P.B.; Stender, S.; Andersson, A.M.; Skakkebaek, N.E.; Frederiksen, H. “Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population.” Environ. Int. 2017, 105, 105–111.
48. Schlumpf, M.; Durrer, S.; Faass, O.; Ehnes, C.; Fuetsch, M.; Gaille, C.; Henseler, M.; Hofkamp, L.; Maerkel, K.; Reolon, S.; et al. “Developmental toxicity of UV filters and environmental exposure: A review.” Int. J. Androl. 2008, 31, 144–151.
49. Kim, S.; Choi, K. “Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: A mini-review.” Environ. Int. 2014, 70, 143–157.
50. Olson, E. “The rub on sunscreen.” New York Times, 19 June 2006.
51. DiNardo, J.C.; Downs, C.A. “Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/benzophenone-3.” J. Cosmet. Dermatol. 2018, 17, 15–19.
52. Huo, W.; Cai, P.; Chen, M.; Li, H.; Tang, J.; Xu, C.; Zhu, D.; Tang, W.; Xia, Y. “The relationship between prenatal exposure to BP-3 and Hirschsprung’s disease.” Chemosphere 2016, 144, 1091–1097.
53. DiNardo, J.C.; Downs, C.A. “Can oxybenzone cause Hirschsprung’s disease?” Reprod. Toxicol. 2019, 86, 98–100.
54. Alamer, M.; Darbre, P.D. “Effects of exposure to six chemical ultraviolet filters commonly used in personal care products on motility of MCF-7 and MDA-MB-231 human breast cancer cells in vitro.” J. Appl. Toxicol. 2018, 38, 148–159.
55. Pollack, A.Z.; Buck Louis, G.M.; Chen, Z.; Sun, L.; Trabert, B.; Guo, Y.; Kannan, K. Bisphenol A, “benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma.” Environ. Res. 2015, 137, 101–107.
56. Phiboonchaiyanan, P.P.; Busaranon, K.; Ninsontia, C.; Chanvorachote, “P. Benzophenone-3 increases metastasis potential in lung cancer cells via epithelial to mesenchymal transition.” Cell Biol. Toxicol. 2017, 33, 251–261.
57. Wang, W.Q.; Duan, H.X.; Pei, Z.T.; Xu, R.R.; Qin, Z.T.; Zhu, G.C.; Sun, L.W. “Evaluation by the Ames assay of the mutagenicity of UV filters using benzophenone and benzophenone-1.” Int. J. Environ. Res. Public Health 2018, 15, 1907.
58. Lim, H.W.; Thomas, L.; Rigel, D.S. “Photoprotection.” In Photoaging; Rigel, D.S., Weiss, R.A., Lim, H.W., Eds.; Marcel Dekker: New York, NY, USA, 2004; 73–88.
59. Schauder, S.; Ippen, H. Contact and photocontact sensitivity to sunscreens. “Review of a 15-year experience and of the literature.” Contact Dermat. 1997, 37, 221–232.
60. Heurung, A.R.; Raju, S.I.; Warshaw, E.M. “Adverse reactions to sunscreen agents: Epidemiology, responsible irritants and allergens, clinical characteristics, and management.” Dermatitis 2014, 25, 289–326.
61. Carrascosa, J.M. El futuro se hace presente en fotoprotección solar. Rev. Piel 2011, 26, 311–314.
62. Sánchez Saldaña, L.; Lanchipa Yokota, P.; Pancorbo Mendoza, J.; Regis Roggero, A.; Saenz Anduaga, E.M. “Fotoprotectores tópicos.” Rev. Peru. Dermatol. 2002, 12, 156–163.
63. EWG’s Low Danger: 1–2. 2018. Available online: https://www.ewg.org/sunscreen/report/executive-summary/#.WxcjvVMvxmB
64. Cosmetics Regulation (EC) No. 1223/2009. Available online: https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009:342:0059:0209:es:PDF
65. Manová, E.; von Goetz, N.; Hungerbühler, K. “Ultraviolet filter contact and photocontact allergy: Consumer exposure and risk assessment for octocrylene from personal care products and sunscreens.” Br. J. Dermatol. 2014, 171, 1368–1374.
66. Bury, D.; Belov, V.N.; Qi, Y.; Hayen, H.; Volmer, D.A.; Brüning, T.; Koch, “H.M. Determination of urinary metabolites of the emerging UV filter octocrylene by online-SPE-LC-MS/MS.” Anal. Chem. 2018, 90, 944–951.
67. Available online: https://ec.europa.eu/growth/content/call-data-ingredients-potential-endocrine-disrupting-properties-used-cosmetic-products_en
68. Elder, D.P.; Snodin, D.J. “Drug substances presented as sulfonic acid salts: Overview of utility, safety and regulation.” J. Pharm. Pharmacol. 2009, 61, 269–278.
69. Fivenson, D.; Sabzevari, N.; Qiblawi, S.; Blitz, J.; Norton, B.B.; Norton, S.A. “Sunscreens: UV filters to protect us: Part 2-Increasing awareness of UV filters and their potential toxicities to us and our environment.” Int. J. Womens Dermatol. 2020, 7, 45–69, PMCID:PMC7838327.
70. Scheuer, E.; Warshaw, E. “Sunscreen allergy: A review of epidemiology, clinical characteristics, and responsible allergens.” Dermatitis 2006, 17, 3–11.
71. Osmond, M.J.; McCall, M.J. “Zinc oxide nanoparticles in modern sunscreens: An analysis of potential exposure and hazard.” Nanotoxicology 2010, 4, 15–41.
72. Hanigan, D.; Truong, L.; Schoepf, J.; Nosaka, T.; Mulchandani, A.; Tanguay, R.L.; Westerhoff, P. “Trade-offs in ecosystem impacts from nanomaterial versus organic chemical ultraviolet filters in sunscreens.” Water Res. 2018, 139, 281–290.
73. Smijs, T.G.; Pavel, S. “Titanium dioxide and zinc oxide nanoparticles in sunscreens: Focus on their safety and effectiveness.” Nanotechnol. Sci. Appl. 2011, 4, 95–112.
74. Schilling, K.; Bradford, B.; Castelli, D.; Dufour, E.; Nash, J.F.; Pape, W.; Schulte, S.; Tooley, I.; van den Bosch, J.; Schellauf, F. “Human safety review of “nano” titanium dioxide and zinc oxide.” Photochem. Photobiol. Sci. 2010, 9, 495–509.
75. Senzui, M.; Tamura, T.; Miura, K.; Ikarashi, Y.; Watanabe, Y.; Fujii, M. “Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro.” J. Toxicol. Sci. 2010, 35, 107–113.
76. Dussert, A.S.; Gooris, E.; Hemmerle, J. “Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum.” Int. J. Cosmet. Sci. 1997, 19, 119–129.
77. Zvyagin, A.V.; Zhao, X.; Gierden, A.; Sanchez, W.; Ross, J.A.; Roberts, “M.S. Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo.” J. Biomed. Opt. 2008, 13, 064031.
78. Scientific Committee on Consumer Safety (SCCS). Opinion on Zinc Oxide (Nano Form). 2012. Available online: http://ec.europa.eu/health/scientific_committ
79. Yabe, S.; Sato, T. “Cerium oxide for sunscreen cosmetics.” J. Solid State Chem. 2003, 171, 7–11.
80. Seixas, V.C.; Serra, O.A. “Stability of sunscreens containing CePO4: Proposal for a new inorganic UV filter.” Molecules 2014, 19, 9907–9925.
81. He, H.; Li, A.; Li, S.; Tang, J.; Li, L.; Xiong, L. “Natural components in sunscreens: Topical formulations with sun protection factor (SPF).” Biomed Pharmacother. 2021, 134, 111161.
82. Matsui, M.S.; Hsia, A.; Miller, J.D.; Hanneman, K.; Scull, H.; Cooper, K.D.; Baron, E. “Non-sunscreen photoprotection: Antioxidants add value to a sunscreen.” J. Investig. Dermatol. Symp. Proc. 2009, 14, 56–59.
83. Landaeta, K.V.; Piombo, M.E. “Estrés oxidativo, carcinogénesis cutánea por radiación solar y quimioproteccion con polifenoles.” Piel 2012, 27, 446–452.
84. Li, S.X.; Li, M.F.; Bian, J.; Wu, X.F.; Peng, F.; Ma, M.G. “Preparation of organic acid lignin submicrometer particle as a natural broad-spectrum photo-protection agent.” Int. J. Biol. Macromol. 2019, 132, 836–843.
85. Netto, M.G.; Jose, J. “Development, characterization, and evaluation of sunscreen cream contain-ing solid lipid nanoparticles of silymarin.” J. Cosmet. Dermatol. 2018, 17, 1073–1083.
86. Álvarez-Gómez, F.; Korbee, N.; Casas-Arrojo, V.; Abdala-Díaz, R.T.; Figueroa, F.L. “UV photoprotection, cytotoxicity and immunology capacity of red algae extracts.” Molecules 2019, 24, 341.
87. Garcia-Pichel, F.; Wingard, C.E.; Castenholz, R.W. “Evidence regarding the UV sunscreen role of a mycosporine-like compound in the cyanobacterium.” Gloeocapsa sp. Appl. Environ. Microbiol. 1993, 59, 170–176.
88. Ahmad, H.I.; Khan, H.M.S.; Akhtar, N. “Development of topical drug delivery system with Sphaeranthus indicus flower extract and its investigation on skin as a cosmeceutical product.” J. Cosmet. Dermatol. 2020, 19, 985–994.
89. Ahmady, A.; Amini, M.H.; Zhakfar, A.M.; Babak, G.; Sediqi, M.N. “Sun protective potential and physical stability of herbal sunscreen de-veloped from afghan medicinal plants.” Turk. J. Pharm. Sci. 2020, 17, 285–292.
90. Baldisserotto, A.; Buso, P.; Radice, M.; Dissette, V.; Lampronti, I.; Gambari, R.; Manfredini, S.; Vertuani, S. “Moringa oleifera leaf extracts as multifunctional ingredients for “natural and organic” sunscreens and photoprotective preparations.” Molecules 2018, 23, 664.
91. Banerjee, K.; Thiagarajan, N.; Thiagarajan, P. “Formulation and characterization of a Heli annuus-alkyl polyglucoside emulsion cream for topical applications.” J. Cosmet. Dermatol. 2019, 18, 628–637.
92. Gaweł-Bęben, K.; Kukula-Koch, W.; Hoian, U.; Czop, M.; “Characterization of Cistus × incanus L. and Cistus ladanifer L. ex-tracts as potential multifunctional antioxidant ingredients for skin protecting cosmetics.” Antioxidants 2020, 9, 202.
93. Hiller, J.; Klotz, K.; Meyer, S.; Uter, W.; Hof, K.; Greiner, A.; Göen, T.; Drexler, H. “Systemic availability of lipophilic organic UV filters through dermal sunscreen exposure.” Environ. Int. 2019, 132, 105068.
94. Witorsch, R.J.; Thomas, J.A. “Personal care products and endocrine disruption: A critical review of the literature.” Crit. Rev. Toxicol. 2010, 40, 515563.
95. Rehfeld, A.; Dissing, S.; Skakkebæk, N.E. “Chemical UV filters mimic the effect of progesterone on Ca2+ signaling in human sperm cells.” Endocrinology 2016, 157, 4297–4308.
96. Ponzo, O.J.; Silvia, C. “Evidence of reproductive disruption associated with neuroendocrine changes induced by UV-B filters, phtalates and nonylphenol during sexual maturation in rats of both gender.” Toxicology 2013, 311, 41–51.
97. Axelstad, M.; Boberg, J.; Hougaard, K.S.; Christiansen, S.; Jacobsen, P.R.; Mandrup, K.R.; Nellemann, C.; Lund, S.P.; Hass, U. “Effects of pre- and postnatal exposure to the UV-filter Octyl Methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring.” Toxicol. Appl. Pharmacol. 2011, 250, 278–290.
98. Ozáez, I.; Martínez-Guitarte, J.L.; Morcillo, G. “Effects of in vivo exposure to UV filters (4-MBC, OMC, BP-3, 4-HB, OC, OD-PABA) on endocrine signaling genes in the insect Chironomus riparius.” Sci. Total Environ. 2013, 456, 120–126.
99. Li, A.J.; Law, J.C.F.; Chow, C.H.; Huang, Y.; Li, K.; Leung, K.S.Y. “Joint Effects of Multiple UV Filters on Zebrafish Embryo Development. Environ.” Sci. Technol. 2018, 52, 9460–9467.
100. Li, V.W.T.; Tsui, M.P.M.; et al. “Effects of 4-methylbenzylidene camphor (4-MBC) on neuronal and muscular development in zebrafish (Danio rerio) embryos.” Environ. Sci. Pollut. Res. 2016, 23, 8275–8285.
101. Balázs, A.; Krifaton, C.; Orosz, I.; Szoboszlay, S.; Kovács, R.; Csenki, Z.; Urbányi, B.; Kriszt, B. “Hormonal activity, cytotoxicity and developmental toxicity of UV filters.” Ecotoxicol. Environ. Saf. 2016, 131, 45–53.
102. Chen, T.H.; Hsieh, C.Y.; Ko, F.C.; Cheng, J.O. “Effect of the UV-filter benzophenone-3 on intra-colonial social behaviors of the false clown anemonefish” (Amphiprion ocellaris). Sci. Total Environ. 2018, 644, 1625–1629.
103. Carvalhais, A.; Pereira, B.; Sabato, M.; Seixas, R.; Dolbeth, M.; Marques, A.; Guilherme, S.; Pereira, P.; Pacheco, M.; Mieiro, C. “Mild effects of sunscreen agents on a marine flatfish: Oxidative stress, energetic profiles, neurotoxicity and behavior in response to titanium dioxide nanoparticles and oxybenzone.” Int. J. Mol. Sci. 2021, 22, 1567.
104. Bahia, M.F. Proteção “Solar—Actualização”, 1st ed.; Universidade do Porto: Porto, Portugal, 2003.
105. Bonda, C.A.; Lott, D. “Sunscreen photostability.” In Principles and Practice of Photoprotection; Springer: Berlin/Heidelberg, Germany, 2016; 247–273.
106. Tarras-Wahlberg, N.; Stenhagen, G.; Larko, O.; Rosen, A.; Wennberg, A.M.; Wennerstrom, O. “Changes in ultraviolet absorption of sunscreens after ultraviolet irradiation. J”. Investig. Dermatol. 1999, 113, 547–553.
107. Stiefel, C.; Schwack, W. Reactions of cosmetic UV filters with skin proteins: Model studies of esters with primary amines. Trends Photochem. Photobiol. 2013, 15, 105–116
108. Sander, Megan et al. “The efficacy and safety of sunscreen use for the prevention of skin cancer.” CMAJ: Canadian Medical Association journal vol. 192,50 2020
109. Latha MS, Martis J, Shobha V, et al. Sun screening agents: a review. The Journal of Clinical and Aesthetic Dermatology. 2013 Jan;6(1):16-26
2. Suh, Susie et al. “The banned sunscreen ingredients and their impact on human health: a systematic review.” International journal of dermatology vol. 59,9 2020
3. Adler, B.L., DeLeo, V.A. “Sunscreen Safety: a Review of Recent Studies on Humans and the Environment.” Curr Derm Rep 9, 1–9 2020
4. Matta MK, Florian J, Zusterzeel R, et al. “Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical Trial.” JAMA. 2020;323(3):256-267.
5. Suh, Susie et al. “The banned sunscreen ingredients and their impact on human health: a systematic review.” International journal of dermatology vol. 59,9 2020
6. Adler, B.L., DeLeo, V.A. “Sunscreen Safety: a Review of Recent Studies on Humans and the Environment.” Curr Derm Rep 9, 1–9 2020
7. "National Academies of Sciences, Engineering, and Medicine. Review of Fate, Exposure, and Effects of Sunscreens in Aquatic Environments and Implications for Sunscreen Usage and Human Health. Washington, DC: The National Academies Press. 2022
8. Khan, Maryam, Alim Husain Naqvi, and Masood Ahmad. "Comparative study of the cytotoxic and genotoxic potentials of zinc oxide and titanium dioxide nanoparticles." Toxicology reports 2 2015: 765-774.
9. A.C. Green, G.M. Williams, V. Logan, G.M. Strutton, “Reduced melanoma after regular sunscreen use: randomized trial follow-up”, J. Clin. Oncol. 29 (3) 2011
10. J.A. Ruszkiewicz, A. Pinkas, B. Ferrer, T.V. Peres, A. Tsatsakis, M. Aschner, “Neurotoxic effect of active ingredients in sunscreen products, a contemporary review”, Toxicol. Rep. 4 2017 245–259
11. Kockler, J.; Oelgemöller, M.; Robertson, S.; Glass, B.D. “Photostability of sunscreens.” J. Photochem. Photobiol. C Photochem. Rev. 2012, 13, 91–110.
12. Valle-Sistac, J.; Molins-Delgado, D.; Díaz, M.; Ibáñez, L.; Barceló, D.; Silvia Díaz-Cruz, M. “Determination of parabens and benzophenone-type UV filters in human placenta: First description of the existence of benzyl paraben and benzophenone-4.” Environ. Int. 2016, 88, 243–249.
13. Rehfeld, A.; Egeberg, D.L.; Almstrup, K.; Petersen, J.H.; Dissing, S.; Skakkebæk, N.E. EDC IMPACT: “Chemical UV filters can affect human sperm function in a progesterone-like manner.” Endocr. Connect. 2018, 7, 16–25.
14. López-Hera, D. “Medicina de Familia en la Red. Cremas Para el Sol Seguras: Como Elegir Fotoprotectores Solares No Tóxicos y Respetuosos Con El Medio Ambiente.” Available online: accessed on 1 September 2022
15. Kiriiri Geoffrey, A.N. Mwangi, S.M. Maru,Sunscreen products: Rationale for use, formulation development and regulatory considerations, Saudi Pharmaceutical Journal,Volume 27, Issue 7,2019,1009-1018,
16. Santander Ballestín, Sonia, and María José Luesma Bartolomé. "Toxicity of Different Chemical Components in Sun Cream Filters and Their Impact on Human Health: A Review" Applied Sciences 13, no. 2: 712. 2023
17. Skotarczak, K.; Osmola-Mańkowska, A.; Lodyga, M.; Polańska, A.; Mazur, M.; Adamski, Z. “Photoprotection: Facts and controversies.” Eur. Rev. Med. Pharmacol. Sci. 2015, 19, 98–112.
18. Narbutt, J. “Does the use of protective creams with UV filters inhibit the synthesis of vitamin D?”—For and against. Prz. Pediatry 2009, 41, 75–81.
19. Yeager, D.G.; Lim, H.W. “What’s new in photoprotection: A review of new concepts and controversies.” Dermatol. Clin. 2019, 37, 149–157.
20. Wang, S.Q.; Balagula, Y.; Osterwalder, U. “Photoprotection: A review of the current and future technologies.” Dermatol. Ther. 2010, 23, 31–47.
21. De Gruijl, F.R.; van Kranen, H.J.; Mullenders, L.H. “UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer.” J. Photochem. Photobiol. B 2001, 63, 19–27.
22. Liu, F.C.; Grimsrud, T.K.; Veierød, M.B.; Robsahm, T.E.; Ghiasvand, R.; Babigumira, R.; Shala, N.K.; Stenehjem, J.S. “Ultraviolet radiation and risk of cutaneous melanoma and squamous cell carcinoma in males and females in the Norwegian Offshore Petroleum Workers cohort.” Am. J. Ind. Med. 2021, 64, 496–510.
23. Duro Mota, E.; Campillos Páez, M.T.; “Causín Serrano, S. El sol y los filtros solares.” Medifam 2003, 13, 39–45.
24. Cole, C.; Shyr, T.; Ou-Yang, H. “Metal Oxide Sunscreens Protect Skin by Absorption, Not by Reflection or Scattering.” Photodermatol. Photoimmunol. Photomed. 2016, 32, 5–10.
25. Kollias, N. “The absorption properties of “physical” sunscreens.” Arch. Dermatol. 1999, 135, 209–210.
26. Garrote, A.; Bonet, R. Fotoprotección. Factores de protección y filtros solares. Offarm 2008, 27, 63–73.
27. Food and Drug Administration (US). “CFR—Code of Federal Regulations Title 21”; 2017, FDA Approved UV Filters for Sunscreens. online: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr
28. FDA Advances New Proposed Regulation to Make Sure That Sunscreens are Safe and Effective. Federal Register 84FR6204, 2019-03019. 2019. Available online: https://www.fda.gov/news-events/press-announcements/fda-advances-new-proposed-regulation-make-sure-sunscreens-are-safe-and-effective
29. Danovaro, R.; Bongiorni, L.; Corinaldesi, C.; Giovannelli, D.; Damiani, E.; Astolfi, P.; Greci, L.; Pusceddu, A. “Sunscreens cause coral bleaching by promoting viral infections.” Environ. Health Perspect. 2008, 116, 441–447.
30. Watkins, Y.S.D.; Sallach, J.B. “Investigating the exposure and impact of chemical UV filters on coral reef ecosystems: Review and research gap prioritization.” Integr. Environ. Assess Manag. 2021, 17, 967–981.
31. National Institute of Health 2020. “Endocrine Disruptors.” Available online: https://www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm
32. Environmental Protection Agency (US). Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and in Topical Sunscreen (Final). EPA/600/R-09/057F. 2010. Available online: https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=230972
33. Environmental Protection Agency (US). Endocrine Disruptor Screening Program. 2010. Available online: https://www.epa.gov/endocrine-disruption
34. “OECD.” Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption; OECD Publishing: Paris, France, 2018.
35. DeLeo, V. “Sunscreen.” In Bolognia J. Dermatology; Elsevier: London, UK, 2012; 2197–2204.
36. Garnacho Saucedo, G.M.; Salido Vallejo, R.; Moreno Giménez, J.C. “Effects of solar radiation and an update on photoprotection.” An. Pediatr. 2020, 92, 377.
37. Maier, T.; Korting, H.C. “Sunscreens—Which and what for?” Skin Pharm. Physiol. 2005, 18, 253–262.
38. Heneweer, M.; Muusse, M.; van den Berg, M.; Sanderson, J.T. “Additive estrogenic effects of mixtures of frequently used UV filters on pS2-gene transcription in MCF-7 cells.” Toxicol. Appl. Pharmacol. 2005, 208, 170–177.
39. Schlumpf, M.; Cotton, B.; Conscience, M.; Hailer, V.; Steinmann, B.; Lichtensteiger, W. “In vitro and in vivo estrogenicity of UV screens. “Environ. Health Perspect. 2001, 109, 239–244.
40. Coronado, M.; De Haro, H.; Deng, X.; Rempel, M.A.; Lavado, R. “Estrogenic activity and reproductive effects of the UV-filter oxybenzone (2-hydroxy-4-methoxyphenyl-methanone) in fish.” Aquat. Toxicol. 2008, 90, 182–187.
41. Krause, M.; Klit, A.; Blomberg Jensen, M.; Søeborg, T.; Frederiksen, H.; Schlumpf, M.; Lichtensteiger, W.; Skakkebaek, N.E.; Drzewiecki, K.T. “Sunscreens: Are they beneficial for health? An overview of endocrine disrupting properties of UV-Filters.” Int. J. Androl. 2012, 35, 424–436.
42. Broniowska, Z.; Slusarczyk, J.; Starek-Swiechowicz, B.; Trojan, E.; Pomierny, B.; Krzyzanowska, W.; Basta-Kaim, A.; Budziszewska, B. “The effect of dermal benzophenone-2 administration on immune system activity, hypothalamic-pituitary-thyroid axis activity and hematological parameters in male Wistar rats.” Toxicology 2018, 1, 1–8.
43. Krzyzanowska, W.; Pomierny, B.; Starek-Swiechowicz, B.; Broniowska, Ż.; Strach, B.; Budziszewska, B. “The effects of benzophenone-3 on apoptosis and the expression of sex hormone receptors in the frontal cortex and hippocampus of rats.” Toxicol. Lett. 2018, 296, 63–72.
44. Schreurs, R.; Lanser, P.; Seinen, W.; van der Burg, B. “Estrogenic activity of UV filters determined by an in vitro reporter gene assay and an in vivo transgenic zebrafish assay.” Arch. Toxicol. 2002, 76, 257–261.
45. Akhiyat, S.; Olasz-Harken, E.B. “Update on human safety and the environmental impact of physical and chemical sunscreen filters: What do we know about the effects of these commonly used and important molecules?” Pract. Dermatol. 2019,48–51. Available online: https://practicaldermatology.com/articles/201
46. Klimova, Z.; Hojerova, J.; Beránkova, M. “Skin absorption and human exposure estimation of three widely discussed UV filters in sunscreens–In vitro study mimicking real-life consumer habits.” Food Chem. Toxicol. 2015, 83, 237–250.
47. Joensen, U.N.; Jorgensen, N.; Thyssen, J.P.; Petersen, J.H.; Szecsi, P.B.; Stender, S.; Andersson, A.M.; Skakkebaek, N.E.; Frederiksen, H. “Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population.” Environ. Int. 2017, 105, 105–111.
48. Schlumpf, M.; Durrer, S.; Faass, O.; Ehnes, C.; Fuetsch, M.; Gaille, C.; Henseler, M.; Hofkamp, L.; Maerkel, K.; Reolon, S.; et al. “Developmental toxicity of UV filters and environmental exposure: A review.” Int. J. Androl. 2008, 31, 144–151.
49. Kim, S.; Choi, K. “Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: A mini-review.” Environ. Int. 2014, 70, 143–157.
50. Olson, E. “The rub on sunscreen.” New York Times, 19 June 2006.
51. DiNardo, J.C.; Downs, C.A. “Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/benzophenone-3.” J. Cosmet. Dermatol. 2018, 17, 15–19.
52. Huo, W.; Cai, P.; Chen, M.; Li, H.; Tang, J.; Xu, C.; Zhu, D.; Tang, W.; Xia, Y. “The relationship between prenatal exposure to BP-3 and Hirschsprung’s disease.” Chemosphere 2016, 144, 1091–1097.
53. DiNardo, J.C.; Downs, C.A. “Can oxybenzone cause Hirschsprung’s disease?” Reprod. Toxicol. 2019, 86, 98–100.
54. Alamer, M.; Darbre, P.D. “Effects of exposure to six chemical ultraviolet filters commonly used in personal care products on motility of MCF-7 and MDA-MB-231 human breast cancer cells in vitro.” J. Appl. Toxicol. 2018, 38, 148–159.
55. Pollack, A.Z.; Buck Louis, G.M.; Chen, Z.; Sun, L.; Trabert, B.; Guo, Y.; Kannan, K. Bisphenol A, “benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma.” Environ. Res. 2015, 137, 101–107.
56. Phiboonchaiyanan, P.P.; Busaranon, K.; Ninsontia, C.; Chanvorachote, “P. Benzophenone-3 increases metastasis potential in lung cancer cells via epithelial to mesenchymal transition.” Cell Biol. Toxicol. 2017, 33, 251–261.
57. Wang, W.Q.; Duan, H.X.; Pei, Z.T.; Xu, R.R.; Qin, Z.T.; Zhu, G.C.; Sun, L.W. “Evaluation by the Ames assay of the mutagenicity of UV filters using benzophenone and benzophenone-1.” Int. J. Environ. Res. Public Health 2018, 15, 1907.
58. Lim, H.W.; Thomas, L.; Rigel, D.S. “Photoprotection.” In Photoaging; Rigel, D.S., Weiss, R.A., Lim, H.W., Eds.; Marcel Dekker: New York, NY, USA, 2004; 73–88.
59. Schauder, S.; Ippen, H. Contact and photocontact sensitivity to sunscreens. “Review of a 15-year experience and of the literature.” Contact Dermat. 1997, 37, 221–232.
60. Heurung, A.R.; Raju, S.I.; Warshaw, E.M. “Adverse reactions to sunscreen agents: Epidemiology, responsible irritants and allergens, clinical characteristics, and management.” Dermatitis 2014, 25, 289–326.
61. Carrascosa, J.M. El futuro se hace presente en fotoprotección solar. Rev. Piel 2011, 26, 311–314.
62. Sánchez Saldaña, L.; Lanchipa Yokota, P.; Pancorbo Mendoza, J.; Regis Roggero, A.; Saenz Anduaga, E.M. “Fotoprotectores tópicos.” Rev. Peru. Dermatol. 2002, 12, 156–163.
63. EWG’s Low Danger: 1–2. 2018. Available online: https://www.ewg.org/sunscreen/report/executive-summary/#.WxcjvVMvxmB
64. Cosmetics Regulation (EC) No. 1223/2009. Available online: https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009:342:0059:0209:es:PDF
65. Manová, E.; von Goetz, N.; Hungerbühler, K. “Ultraviolet filter contact and photocontact allergy: Consumer exposure and risk assessment for octocrylene from personal care products and sunscreens.” Br. J. Dermatol. 2014, 171, 1368–1374.
66. Bury, D.; Belov, V.N.; Qi, Y.; Hayen, H.; Volmer, D.A.; Brüning, T.; Koch, “H.M. Determination of urinary metabolites of the emerging UV filter octocrylene by online-SPE-LC-MS/MS.” Anal. Chem. 2018, 90, 944–951.
67. Available online: https://ec.europa.eu/growth/content/call-data-ingredients-potential-endocrine-disrupting-properties-used-cosmetic-products_en
68. Elder, D.P.; Snodin, D.J. “Drug substances presented as sulfonic acid salts: Overview of utility, safety and regulation.” J. Pharm. Pharmacol. 2009, 61, 269–278.
69. Fivenson, D.; Sabzevari, N.; Qiblawi, S.; Blitz, J.; Norton, B.B.; Norton, S.A. “Sunscreens: UV filters to protect us: Part 2-Increasing awareness of UV filters and their potential toxicities to us and our environment.” Int. J. Womens Dermatol. 2020, 7, 45–69, PMCID:PMC7838327.
70. Scheuer, E.; Warshaw, E. “Sunscreen allergy: A review of epidemiology, clinical characteristics, and responsible allergens.” Dermatitis 2006, 17, 3–11.
71. Osmond, M.J.; McCall, M.J. “Zinc oxide nanoparticles in modern sunscreens: An analysis of potential exposure and hazard.” Nanotoxicology 2010, 4, 15–41.
72. Hanigan, D.; Truong, L.; Schoepf, J.; Nosaka, T.; Mulchandani, A.; Tanguay, R.L.; Westerhoff, P. “Trade-offs in ecosystem impacts from nanomaterial versus organic chemical ultraviolet filters in sunscreens.” Water Res. 2018, 139, 281–290.
73. Smijs, T.G.; Pavel, S. “Titanium dioxide and zinc oxide nanoparticles in sunscreens: Focus on their safety and effectiveness.” Nanotechnol. Sci. Appl. 2011, 4, 95–112.
74. Schilling, K.; Bradford, B.; Castelli, D.; Dufour, E.; Nash, J.F.; Pape, W.; Schulte, S.; Tooley, I.; van den Bosch, J.; Schellauf, F. “Human safety review of “nano” titanium dioxide and zinc oxide.” Photochem. Photobiol. Sci. 2010, 9, 495–509.
75. Senzui, M.; Tamura, T.; Miura, K.; Ikarashi, Y.; Watanabe, Y.; Fujii, M. “Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro.” J. Toxicol. Sci. 2010, 35, 107–113.
76. Dussert, A.S.; Gooris, E.; Hemmerle, J. “Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum.” Int. J. Cosmet. Sci. 1997, 19, 119–129.
77. Zvyagin, A.V.; Zhao, X.; Gierden, A.; Sanchez, W.; Ross, J.A.; Roberts, “M.S. Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo.” J. Biomed. Opt. 2008, 13, 064031.
78. Scientific Committee on Consumer Safety (SCCS). Opinion on Zinc Oxide (Nano Form). 2012. Available online: http://ec.europa.eu/health/scientific_committ
79. Yabe, S.; Sato, T. “Cerium oxide for sunscreen cosmetics.” J. Solid State Chem. 2003, 171, 7–11.
80. Seixas, V.C.; Serra, O.A. “Stability of sunscreens containing CePO4: Proposal for a new inorganic UV filter.” Molecules 2014, 19, 9907–9925.
81. He, H.; Li, A.; Li, S.; Tang, J.; Li, L.; Xiong, L. “Natural components in sunscreens: Topical formulations with sun protection factor (SPF).” Biomed Pharmacother. 2021, 134, 111161.
82. Matsui, M.S.; Hsia, A.; Miller, J.D.; Hanneman, K.; Scull, H.; Cooper, K.D.; Baron, E. “Non-sunscreen photoprotection: Antioxidants add value to a sunscreen.” J. Investig. Dermatol. Symp. Proc. 2009, 14, 56–59.
83. Landaeta, K.V.; Piombo, M.E. “Estrés oxidativo, carcinogénesis cutánea por radiación solar y quimioproteccion con polifenoles.” Piel 2012, 27, 446–452.
84. Li, S.X.; Li, M.F.; Bian, J.; Wu, X.F.; Peng, F.; Ma, M.G. “Preparation of organic acid lignin submicrometer particle as a natural broad-spectrum photo-protection agent.” Int. J. Biol. Macromol. 2019, 132, 836–843.
85. Netto, M.G.; Jose, J. “Development, characterization, and evaluation of sunscreen cream contain-ing solid lipid nanoparticles of silymarin.” J. Cosmet. Dermatol. 2018, 17, 1073–1083.
86. Álvarez-Gómez, F.; Korbee, N.; Casas-Arrojo, V.; Abdala-Díaz, R.T.; Figueroa, F.L. “UV photoprotection, cytotoxicity and immunology capacity of red algae extracts.” Molecules 2019, 24, 341.
87. Garcia-Pichel, F.; Wingard, C.E.; Castenholz, R.W. “Evidence regarding the UV sunscreen role of a mycosporine-like compound in the cyanobacterium.” Gloeocapsa sp. Appl. Environ. Microbiol. 1993, 59, 170–176.
88. Ahmad, H.I.; Khan, H.M.S.; Akhtar, N. “Development of topical drug delivery system with Sphaeranthus indicus flower extract and its investigation on skin as a cosmeceutical product.” J. Cosmet. Dermatol. 2020, 19, 985–994.
89. Ahmady, A.; Amini, M.H.; Zhakfar, A.M.; Babak, G.; Sediqi, M.N. “Sun protective potential and physical stability of herbal sunscreen de-veloped from afghan medicinal plants.” Turk. J. Pharm. Sci. 2020, 17, 285–292.
90. Baldisserotto, A.; Buso, P.; Radice, M.; Dissette, V.; Lampronti, I.; Gambari, R.; Manfredini, S.; Vertuani, S. “Moringa oleifera leaf extracts as multifunctional ingredients for “natural and organic” sunscreens and photoprotective preparations.” Molecules 2018, 23, 664.
91. Banerjee, K.; Thiagarajan, N.; Thiagarajan, P. “Formulation and characterization of a Heli annuus-alkyl polyglucoside emulsion cream for topical applications.” J. Cosmet. Dermatol. 2019, 18, 628–637.
92. Gaweł-Bęben, K.; Kukula-Koch, W.; Hoian, U.; Czop, M.; “Characterization of Cistus × incanus L. and Cistus ladanifer L. ex-tracts as potential multifunctional antioxidant ingredients for skin protecting cosmetics.” Antioxidants 2020, 9, 202.
93. Hiller, J.; Klotz, K.; Meyer, S.; Uter, W.; Hof, K.; Greiner, A.; Göen, T.; Drexler, H. “Systemic availability of lipophilic organic UV filters through dermal sunscreen exposure.” Environ. Int. 2019, 132, 105068.
94. Witorsch, R.J.; Thomas, J.A. “Personal care products and endocrine disruption: A critical review of the literature.” Crit. Rev. Toxicol. 2010, 40, 515563.
95. Rehfeld, A.; Dissing, S.; Skakkebæk, N.E. “Chemical UV filters mimic the effect of progesterone on Ca2+ signaling in human sperm cells.” Endocrinology 2016, 157, 4297–4308.
96. Ponzo, O.J.; Silvia, C. “Evidence of reproductive disruption associated with neuroendocrine changes induced by UV-B filters, phtalates and nonylphenol during sexual maturation in rats of both gender.” Toxicology 2013, 311, 41–51.
97. Axelstad, M.; Boberg, J.; Hougaard, K.S.; Christiansen, S.; Jacobsen, P.R.; Mandrup, K.R.; Nellemann, C.; Lund, S.P.; Hass, U. “Effects of pre- and postnatal exposure to the UV-filter Octyl Methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring.” Toxicol. Appl. Pharmacol. 2011, 250, 278–290.
98. Ozáez, I.; Martínez-Guitarte, J.L.; Morcillo, G. “Effects of in vivo exposure to UV filters (4-MBC, OMC, BP-3, 4-HB, OC, OD-PABA) on endocrine signaling genes in the insect Chironomus riparius.” Sci. Total Environ. 2013, 456, 120–126.
99. Li, A.J.; Law, J.C.F.; Chow, C.H.; Huang, Y.; Li, K.; Leung, K.S.Y. “Joint Effects of Multiple UV Filters on Zebrafish Embryo Development. Environ.” Sci. Technol. 2018, 52, 9460–9467.
100. Li, V.W.T.; Tsui, M.P.M.; et al. “Effects of 4-methylbenzylidene camphor (4-MBC) on neuronal and muscular development in zebrafish (Danio rerio) embryos.” Environ. Sci. Pollut. Res. 2016, 23, 8275–8285.
101. Balázs, A.; Krifaton, C.; Orosz, I.; Szoboszlay, S.; Kovács, R.; Csenki, Z.; Urbányi, B.; Kriszt, B. “Hormonal activity, cytotoxicity and developmental toxicity of UV filters.” Ecotoxicol. Environ. Saf. 2016, 131, 45–53.
102. Chen, T.H.; Hsieh, C.Y.; Ko, F.C.; Cheng, J.O. “Effect of the UV-filter benzophenone-3 on intra-colonial social behaviors of the false clown anemonefish” (Amphiprion ocellaris). Sci. Total Environ. 2018, 644, 1625–1629.
103. Carvalhais, A.; Pereira, B.; Sabato, M.; Seixas, R.; Dolbeth, M.; Marques, A.; Guilherme, S.; Pereira, P.; Pacheco, M.; Mieiro, C. “Mild effects of sunscreen agents on a marine flatfish: Oxidative stress, energetic profiles, neurotoxicity and behavior in response to titanium dioxide nanoparticles and oxybenzone.” Int. J. Mol. Sci. 2021, 22, 1567.
104. Bahia, M.F. Proteção “Solar—Actualização”, 1st ed.; Universidade do Porto: Porto, Portugal, 2003.
105. Bonda, C.A.; Lott, D. “Sunscreen photostability.” In Principles and Practice of Photoprotection; Springer: Berlin/Heidelberg, Germany, 2016; 247–273.
106. Tarras-Wahlberg, N.; Stenhagen, G.; Larko, O.; Rosen, A.; Wennberg, A.M.; Wennerstrom, O. “Changes in ultraviolet absorption of sunscreens after ultraviolet irradiation. J”. Investig. Dermatol. 1999, 113, 547–553.
107. Stiefel, C.; Schwack, W. Reactions of cosmetic UV filters with skin proteins: Model studies of esters with primary amines. Trends Photochem. Photobiol. 2013, 15, 105–116
108. Sander, Megan et al. “The efficacy and safety of sunscreen use for the prevention of skin cancer.” CMAJ: Canadian Medical Association journal vol. 192,50 2020
109. Latha MS, Martis J, Shobha V, et al. Sun screening agents: a review. The Journal of Clinical and Aesthetic Dermatology. 2013 Jan;6(1):16-26
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Dec 11, 2024
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Joshi Aryan, Ms. Krupa Vyas, & Dr. Pragnesh Patani. (2024). NAVIGATING THE CHALLENGES AND CONTROVERSIES IN SUNSCREEN: A REVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 986-997. https://doi.org/10.53555/crgtsp35
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Author Biographies
Joshi Aryan
Student, Khyati College of Pharmacy, Palodia, Ahmedabad.
Ms. Krupa Vyas
Assistant Professor, Khyati College of Pharmacy, Palodia, Ahmedabad
Dr. Pragnesh Patani
Principal and Professor, Khyati College of Pharmacy, Palodia, Ahmedabad
How to Cite
Joshi Aryan, Ms. Krupa Vyas, & Dr. Pragnesh Patani. (2024). NAVIGATING THE CHALLENGES AND CONTROVERSIES IN SUNSCREEN: A REVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 986-997. https://doi.org/10.53555/crgtsp35