ASSOCIATION OF HYPERGLYCEMIA AND HYPERURICEMIA IN DIABETIC PATIENTS AT TERTIARY CARE HOSPITALS
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Keywords
Serum uric Acid, hyperglycemia, Diabetes Mellitus, Metabolic Syndrome
Abstract
Background: Uric acid is created by the external breakdown through the metabolism of purines that come from dietary intake, as well as by endogenous decomposition of those cells that are dead. Approximately 90% of filtrated serum uric acid (SUA) gets absorbed again, demonstrating its vital role in the human body
Objective: The objective of the study was to find out the possible association between hyperglycemia and hyperuricemia among diabetes mellitus patients in tertiary care hospitals.
Methodology: The current analytical cross-sectional was conducted at the department of Biochemistry Mohtarma Benazir Bhutto Shaheed medical college Mirpur for a period of six months from July 2023 to December 2023 after approval from the ethical review board of the hospital. All the participants were selected through a convenient sampling technique. The total sample size was 217, though the WHO calculator with a 95 % confidence interval and a 5 % margin of error. Proper informed consent was obtained from all the participants after ensuring confidentiality and anonymity. Descriptive statistics were assessed using mean, standard deviation, frequency, and percentages. Statistical significance was defined as a P-value of <0.05.
Results: A total of 217 patients were included in the study, consequently, they all were screened for the purpose of their glucose level as well as serum uric acid level. Out of the total 119 were male and 98 were female patients. . 46 (21.19 %) of the total patients have high uric acid levels of which 27 (12.44 %) were male and female patients account for 19 (8.75 %). From 36-45 and 46-60 years of age, 20.31 % and 23.17 % have high uric acid levels, additionally, above 60 years of age 37.05 % have above-normal uric acid levels. There was a negative relationship between hyperglycemia and hyperuricemia with a p-value of 0.78.
Conclusion: This concluded that there was a negative relationship between high serum uric acid and hyperglycemia, however, the level of uric acid was found higher in later age, those with above 40 years of age participants.
References
2. Higgins P, Ferguson LD, Walters MR. Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach. Expert review of cardiovascular therapy. 2011 Apr 1;9(4):399-401.
3. Roep BO, Thomaidou S, van Tienhoven R, Zaldumbide A. Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?). Nature Reviews Endocrinology. 2021 Mar;17(3):150-61.
4. Care D. Standards of medical care in diabetes 2019. Diabetes Care. 2019 Jan 1;42(Suppl 1):S124-38.
5. Bellary S, Kyrou I, Brown JE, Bailey CJ. Type 2 diabetes mellitus in older adults: clinical considerations and management. Nature Reviews Endocrinology. 2021 Sep;17(9):534-48.
6. Chattaraj KG, Paul S. Underlying Mechanisms of Allopurinol in Eliminating Renal Toxicity Induced by Melamine–Uric Acid Complex Formation: A Computational Study. Chemical Research in Toxicology. 2021 Aug 19;34(9):2054-69.
7. Ghasemi A. Uric acid‐induced pancreatic β-cell dysfunction. BMC endocrine disorders. 2021 Feb 16;21(1):24.
8. Haque T, Rahman S, Islam S, Molla NH, Ali N. Assessment of the relationship between serum uric acid and glucose levels in healthy, prediabetic and diabetic individuals. Diabetology & metabolic syndrome. 2019 Dec;11:1-8.
9. Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, et al. Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care. (2017) 40:136–54. doi: 10.2337/dc16-2042
10. Boulton AJ, Armstrong DG, Kirsner RS, Attinger CE, Lavery LA, Lipsky BA, Mills Sr JL, Steinberg JS. Diagnosis and management of diabetic foot complications.
11. Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes care. 2017 Jan;40(1):136.
12. Sloan G, Selvarajah D, Tesfaye S. Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nature Reviews Endocrinology. 2021 Jul;17(7):400-20.
13. El Din UA, Salem MM, Abdulazim DO. Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: a review. Journal of advanced research. 2017 Sep 1;8(5):537-48.
14. Basit A, Shera AS. Prevalence of metabolic syndrome in Pakistan. Metabolic syndrome and related disorders. 2008 Sep 1;6(3):171-5.
15. Ullah A, Haq MU, Khan MS, Ullah I. Association of Hyperglycemia and Hyperuricemia in Diabetic Patients at Tertiary Care Hospitals of District Bannu, Khyber Pakhtunkhwa, Pakistan. BMC Journal of Medical Sciences. 2021;2(2):51-4.
16. Barbieri L, Verdoia M, Schaffer A, Marino P, Suryapranata H, De Luca G, Novara Atherosclerosis Study Group. Impact of sex on uric acid levels and its relationship with the extent of coronary artery disease: A single-centre study. Atherosclerosis. 2015 Jul 1;241(1):241-8.
17. Dehghan A, Van Hoek M, Sijbrands EJ, Hofman A, Witteman JC. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes care. 2008 Feb 1;31(2):361-2.
18. Kodama S, Saito K, Yachi Y, Asumi M, Sugawara A, Totsuka K, Saito A, Sone H. Association between serum uric acid and development of type 2 diabetes. Diabetes care. 2009 Sep 1;32(9):1737-42.
19. Bandaru P, Shankar A. Association between serum uric acid levels and diabetes mellitus. International journal of endocrinology. 2011;2011(1):604715.
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Najma Majeed
Assistant Professor Biochemistry, Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur,AJK
Uzma Riaz
Associate Professor Pharmacology, Benazir Bhutto Medical College, Mirpur, AJK
Mehwish Iftikhar
Assistant Professor Biochemistry, King Edward Medical University, Lahore, Pakistan