ASSOCIATION BETWEEN MALE ERECTILE DYSFUNCTION (MED) AND LEVELS OF VITAMIN D IN INDIVIDUALS WITH DIABETES MELLITUS (TYPE II)
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Keywords
Male Erectile Dysfunction, Vitamin D, Diabetes Mellitus
Abstract
Background: Present investigations have recommended that an association could be present between Vitamin D deficiency and male erectile dysfunction (MED).
Objective: The current investigation assessed the association between vitamin D levels and MED in individuals with type 2 diabetes mellitus (DM).
Methodology: The investigation included 150 participants with type 2 DM aged between 19-75 years. The questionnaire known as the ‘International Index of Erectile Function’ (IIEF-5) was used. Based on their IIEF-5 score, the participants were divided into three categories: those with ‘severe ED’ (IIEF-5 score between 5 and 10); ‘moderate ED’ (IIEF-5 score between 11 and 20); and ‘no ED’ (IIEF-5 score between 21 and 25). Every individual had their biochemical variables, vitamin D, and hormonal assessment performed. The three categories were evaluated on all characteristics.
Results: Out of 150 participants that were part of the investigation, 38 patients (25.3%) were not diagnosed with erectile dysfunction, whereas 112 patients (74.6%) satisfied the criteria for ED (IIEF-5 < 21). The mean age was 60.25 ± 9.86 years and the average level of vitamin D was 14.78 ± 9.26 ng/ml. Vitamin D levels were quite distinct among all three categories (p =0.031) when the participants were split into three categories based on IIEF-5 assessment. Specifically, there was a significant difference in vitamin D levels between patients who had an IIEF-5 score of 5–10 points and those who had a score of 11–20 points (p < 0.027). There were age differences (p=0.022) across the three categories.
Conclusion: In conclusion, MED and vitamin D insufficiency are significantly correlated in male patients with diabetes type 2 mellitus. This association is thought to be driven by the increased synthesis of nitric oxide in vascular cells caused by vitamin D through a variety of routes, the repression of apoptosis, and the avoidance of endothelial dysfunction through the suppression of oxidative stress. In conclusion, there is a correlation between vitamin D levels and ED scores, particularly for males with type 2 diabetes mellitus who are among the ages of 40 and 60.
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Dr. Shahid Shehzad
Assistant Professor of Endocrinology, Department of Diabetes and Endocrinology, Mercy Teaching Hospital, Peshawar Medical College, Riphah International University, Islamabad
Dr. Munir Khan
Medical Officer, Urology Department, Mian Rashid Hussain Shaheed Memorial Hospital, Pabbi, District Nowshehra
Dr. Ambreen Gul
Associate Professor Chemical Pathology, Peshawar Medical College, Riphah International University, Islamabad
Dr. Shabina Saifullah
Assistant Professor, Department of Chemical Pathology, Peshawar Medical College, Riphah International University, Islamabad.
Dr. Khalid Shehzad
Lecturer Department of Anatomy, College of Medicine, Qassim University