PHARMACOGNOSTIC AND PHYTOCHEMICAL ANALYSIS OF FICUS RUMPHII BL.: UNVEILING ITS THERAPEUTIC POTENTIAL THROUGH MODERN SCIENTIFIC APPROACHES
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Keywords
Ficus rumphii Bl, Moraceae family, neurodegenerative diseases, Ficus genus
Abstract
This study evaluates the pharmacognostic features and phytochemical makeup of Ficus rumphii Bl., a plant classified under the Moraceae family. The plant has undergone thorough examination for its pharmacological activity, encompassing antibacterial, antioxidant, anti-inflammatory, antidiabetic, and anticancer characteristics. “The plant's extracts have demonstrated the ability to decrease markers of oxidative stress, decrease the expression of pro-inflammatory cytokines, decrease blood glucose levels in models of diabetes, inhibit the growth of various cancer cell lines, shield liver cells from damage caused by toxins and oxidative stress, alleviate neurotoxicity, and enhance cognitive functions.” These findings suggest that the plant extracts can potentially treat neurodegenerative diseases. The study also compared Ficus rumphii Bl. with other species belonging to the Ficus genus to emphasize its commonalities and distinctive characteristics. The results validated the ethnomedicinal significance of Ficus rumphii Bl., providing evidence for its traditional application in treating many diseases. Further investigation should prioritize the isolation and characterization of certain bioactive chemicals, comprehending their mechanisms of action, and conducting clinical studies to confirm the therapeutic effectiveness of Ficus rumphii in humans.
References
2. Prasad, A. et al. (2016). "Hepatoprotective and neuroprotective properties of Ficus religiosa." Pharmacognosy Reviews, 10(20), 73-80.
3. Riaz, M. et al. (2018). "Antimicrobial properties of flavonoids and phenolic compounds from Ficus carica and Ficus religiosa." Asian Pacific Journal of Tropical Biomedicine, 8(5), 371-376.
4. Sharma, V. et al. (2015). "Anti-inflammatory activity of Ficus racemosa." Journal of Ayurveda and Integrative Medicine, 6(1), 10-15.
5. Solomon, T. et al. (2017). "Antidiabetic potential of Ficus carica." Journal of Medicinal Plants Research, 11(29),448-455.
6. Wu, X. et al. (2018). "Anticancer effects of Ficus hirta on human cancer cell lines." BioMed Research International, 2018, Article ID 6947604.
7. Adeyanju O, Lajide L, Ajayi OO, Amoo IA. 2014. Morphological and physicochemical characterization of ipin gum (Ficus elastica). Scholars Acad J Biosci 2 (11): 773-777. DOI: 10.13005/bbra/1335.
8. Afifudin Y, Marpaung L, Silitonga Y. 2015. Eksplorasi tumbuhan beracun di Cagar Alam Mertelu Purba. Peronema Fore Sci J 4 (2): 92-102. [Indonesian]
9. Akhtar P, Yaakob Z, Ahmed Y, Shahinuzzaman Md. 2019. Ficus species good sources of natural antioxidant drugs. Turk J Pharm Sci 2: 1-14.
10. Al-Khdhairawi AAQ, Krishnan P, Mai C, Chung FF, Leong C, Yong K, Chong K, Low Y, Kam T, Lim K. 2017. A bis-benzopyrroloisoquinoline alkaloid incorporating a cyclobutene core and achlorophenanthroindolizidine alkaloid with cytotoxic activity from Ficus fistulosa var tengerensis. J Nat Prod 80 (10): 2734-2740. DOI: 10.1021/acs.jnatprod.7b00500.
11. Alqasoumi SI, Basudan OA, Al-Rehaily AJ, Abdel-Kader MS. 2014. Phytochemical and pharmacological study of Ficus palmata growing in Saudi Arabia. Saudi Pharm J 22 (5): 460-471. DOI: 10.1016/j.jsps.2013.12.010.
12. Al-Snafi AE. 2017. Pharmacology of Ficus religiosa- a review. IOSR J Pharm 7 (3): 49-60. DOI: 10.9790/3013-0703014960.
13. Anisa K, Rahayu T, Hayati A. 2018. Secondary metabolite profile of Ficus carica through histochemical analysis and flavonoids detection by thin-layer chromatography (TLC). E-Jurnal Ilmiah Sains Alami 1 (1): 104-110. DOI: 10.33474/j.sa.v1i1.1266. [Indonesian]
14. Anjum N, Tripathi YC. 2019a. In vitro alpha-amylase and alpha-glucosidase inhibitory activities of fruits of Ficus auriculata Lour. Intl J Pharm Biosci 10 (4): 134-141. DOI: 10.22376/ijpbs.2019.10.4.p134-141.
15. Anjum N, Tripathi YC. 2019b. Phytochemical screening and in vitro evaluation of antidiabetic activity of Ficus palmata fruits. Europ J Pharm Med Res 6 (11): 251-258.
16. Arbi TA, Guntara DJ. 2021. Minimum inhibitory and bactericidal concentration of the hydrogel formula of tin’s leaf (Ficus carica) towards the growth of Staphylococcus aureus. Cakradonya Dent J 13 (1): 22-31. DOI: 10.24815/cdj.v13i1.20915.
17. Aritan J, Mongie J, Untu S, Pareta D. 2019. Uji toksititas akut ekstrak etanol daun tagalolo Ficus septica Burm f terhadap larva Artemia salina leach dengan metode brine shrimp lethality test (bslt). J Biofarmasetikal Tropis 2 (1): 85-90. DOI: 10.30602/jlk.v2i1.320. [Indonesian]
18. Ashraf A, Zafar S, Ashraf MY, Ijaz MU, Muzammal S, Asad F, Jabeen F, Shahid M. 2020. Phytochemical composition and potent biological activities of Ficus benjamina var comosa leaves extract. Pak J Bot 52 (2): 531-535. DOI: 10.30848/PJB2020-2(3).
19. Asis J, Yusoff N, Mat N. 2018. Allelopathic assessments of Ficus deltoidea varietas and Ficus microcarpa. J Agrobiotech 9 (1S): 214-221.
20. Awad NE, Abdelqawy MA, Hamed MA, Aboshehata MM. 2018. Quantitation and characterization of phenolic compounds in butanol fraction of Ficus lyrata leaves and in vivo assessment of hepatoprotective and hypocholesterolemic activities in rats. J Herbs Spices Med Plants 25 (4): 1-17. DOI: 10.1080/10496475.2019.1619650.
21. Awolola GV, Chenia H, Baijnath H, Koorbanally NA. 2017. Anti-adhesion potential of non-polar compounds and extracts from Ficus natalensis. Revista Brasileira de Farmacognosia 27: 599-602. DOI: 10.1016/j.bjp.2017.07.004.
22. Bagyalakshmi B, Nivedhitha P, Balamurugan A. 2019. Studies on phytochemical analysis, antioxidant and antibacterial activity of Ficus racemose L. leaf and fruit extracts against wound pathogens. Vegetos 32 (1): 58-63.DOI: 10.1007/s42535-019-00007-6.
23. Bahri S, Ambarwati Y, Marlina L, Utami. 2020. Identification of phenyl propanoid compound isolated from root bark datuan (Ficus vasculosa Wall. Ex Miq) and antibacterial activity test on Eshcerichia coli. IOP Conf Ser Earth Environ Sci 537: 1-9. DOI: 10.1088/1755-1315/537/1/012046.
24. Bairagi SM, Aher AA, Nema N, Pathan IB. 2014. Evaluation of anti-diarrhoeal activity of the leaves extract of Ficus Microcarpa L. (Moraceae). Marmara Pharm J 18 (3): 135-138. DOI: 10.12991/mpj.2014187240.
25. Bala A, Singh AP, Singh AP. 2021. Phytopharmaceutical profile of Ficus thonningii: An updated review. World J Curr Med Pharm Res 3 (4): 104-106. DOI: 10.37022/wjcmpr.v3i4.188.
26. Baskara B, Wicaksono KP. 2013. Tumbuhan Ficus: Penjaga keberlanjutan budaya dan ekonomi di lingkungan karst. Prosiding Temu Ilmiah IPLBI 2013. [Indonesian]
27. Bawondes JN, Maarisit W, Ginting A, Kanter J. 2021. Uji aktivitas antibakteri ekstrak etanol buah awar-awar Ficus septica Burm.f terhadap Staphylococcus aureus. J Biofarmasetikal Tropis 4 (1): 21-29. [Indonesian]
28. Berg CC. 2003. Flora Malesiana precursor for the treatment of Moraceae 1: The main subdivision of Ficus: the subgenera. Blumea 48 (1): 167-178. DOI: 10.3767/000651903X686132.
29. Bertoletti LL, Skoronski E, Moroni LS, Kempka AP. 2020. Extracts of branches and fruit of Ficus auriculata Lour.: Antioxidant, antimicrobial and phytotoxic activities. Agriculturae Conspectus Scientificus 85 (4): 303-310.
30. Bertoletti LL, Skoronski E, Schittler L, Kempka AP. 2018. Extracts of leaves of Ficus auriculata Lour.: Antioxidant, antimicrobial, and phytotoxic activity. Agriculturae Conspectus Scientificus 83 (4): 321-328.
31. Bhogaonkar PY, Chavhan VN, Kanerkar UR. 2014. Nutritional potential of Ficus racemosa L. fruits. Biosci Discov 5 (2): 150-153.
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Madhulika Krishan Yadav
Shri Jagdishprasad Jhabarmal Tibrewala University, Rajasthan 333001, India
Dr. Dinesh Kumar Singh
Shri Jagdishprasad Jhabarmal Tibrewala University, Rajasthan 333001, India