RANDOMIZED STUDY ON GLUCOSE AND LIPID METABOLIC PARAMETERS IN TYPE-II DIABETICS BY MULTISTRAIN PROBIOTIC SUPPLEMENTATION
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Keywords
Diabetes Mellitus, lipid profiles, gastrointestinal microbiota, Probiotics, Anthropometric parameters
Abstract
Diabetes Mellitus type 2 patients were assessed over a six-month period for metabolic and glycemic responses. Sixty participants were divided into two groups and received standard treatment and probiotic treatment. Baseline, three month, and six month measurements were taken of anthropometric and biochemical parameters. The probiotic group had significantly higher average ages, BMIs, waist-hip ratios, and blood pressures at baseline in comparison to Group I (standard treatment group), with p-values of 0.0321, 0.006, 0.0158, and 0.0223 (systolic) and 0.0297 (diastolic), respectively. Over the study period, Group II exhibited a significant reduction in glucose levels from 174.20±3.708 mg/dl to 147.63±5.275 mg/dl (p=0.0327). It does not appear that there is a statistically significant difference between the two groups, despite the fact that insulin and C-peptide levels were lower in both groups (p=0.829 and p=0.623, respectively). Although the difference wasn't significant (p<0.567), HOMA-IR values decreased more significantly in Group II. There were significant improvements in lipid profiles in both groups, with HDL-cholesterol in Group II increasing from 47.69 to 55.933mg/dl (p=0.0299). Also, triglycerides and LDL cholesterol levels decreased more in Group II, but not significantly (p=0.1219 and p=0.1758). Over the course of six months, glucose control and HDL cholesterol levels were significantly improved in T2DM patients who were treated with probiotics. The findings suggest that probiotics may be a helpful adjunct therapy for the treatment of diabetes type 2.
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Dr. Lavanya R
Assistant Professor, Department of Pharmacology, Faculty of Medicine, Sri Lalithambigai Medical College & Hospital, Dr. M. G.R. Educational and Research Institute, Chennai 95, Tamilnadu, India.
Dr. Soumya Annu Achankunju
Assistant Professor, Department of Pharmacology, Faculty of Medicine, Sri Lalithambigai Medical College & Hospital, Dr. M. G.R. Educational and Research Institute, Chennai 95, Tamilnadu, India.