PROTECTIVE EFFECTS OF MUSA PARADISIACA FRUIT EXTRACT AGAINST REPRODUCTIVE TOXICITY IN FEMALE RATS EXPOSED TO BISPHENOL A (BPA)
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Abstract
Bisphenol A (BPA) is a prevalent endocrine-disrupting chemical that poses risks to female reproductive health. In this study, we substantiated the traditional claim of the efficacy of Musa paradisiaca (banana) fruit plus peel in treating female reproductive system disorders. we investigated the potential protective effects of M. paradisiaca (banana) fruit extract against BPA-induced reproductive toxicity in female rats. The hydroalcoholic extract of M. paradisiaca fruit was administered to female Wistar rats exposed to BPA. The animals were divided into different groups: control, BPA-exposed, and Musa paradisiaca extract pre-treated followed by BPA exposure. Serum hormonal levels, histopathological changes in ovarian tissues, and estrous cyclicity were assessed to evaluate the protective effects. Our results revealed that BPA exposure led to disruptions in reproductive parameters, including altered hormonal profiles and abnormal estrous cycles. However, pre-treatment with M. paradisiaca fruit extract mitigated these adverse effects, restoring hormonal balance and promoting more regular estrous cycles. Histopathological examination showed improvements in ovarian tissue architecture in the M. paradisiaca extract pre-treated group compared to the BPA-exposed group. Our study provides supporting evidence for the traditional use of M. paradisiaca fruit plus peel in treating female reproductive system disorders, further highlighting the potential of natural remedies for female reproductive health. These findings suggest that M. paradisiaca fruit extract may possess protective properties against BPA-induced reproductive toxicity in female rats. The observed effects may be attributed to the presence alkaloids, terpenes, and flavonoids (phenolic compounds) in the extract. Our findings are consistent with previous research indicating that these compounds possess potential anti-infertility effects due to their radical scavenging and antioxidant properties. warranting further investigation to understand the underlying mechanisms and explore its potential therapeutic applications for female reproductive health.
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Maryam Khan
College of Pharmacy, University of Sargodha, 40100 Sargodha, Pakistan
Hafiz M. Irfan
College of Pharmacy, University of Sargodha, 40100 Sargodha, Pakistan
Taseer Ahmed Khan
The Department of Physiology, University of Karachi, 75270 Karachi, Pakistan.