NEW INSIGHTS INTO SAFE AND EFFECTIVE MANAGEMENT OF DERMATITIS WITH POLYHERBAL FORMULATION
Main Article Content
Keywords
Dermatitis, Immunological response of dermatitis, Pathology of dermatitis, herbal treatment
Abstract
Dermatitis, a chronic inflammatory skin disorder characterized by cutaneous hyperactivity to environmental stimuli, serve as a pivotal point in the dermatitis rhythmic stride, often initiating a cascade leading to asthma, allergic rhinitis, and other associated manifestations. The clinical phenotype of dermatitis results from a complex interplay involving susceptibility genes, compromised skin barrier functions, and immunologic responses to environmental triggers. This review explores these multifaceted aspects, providing a comprehensive overview of the recent advancements in dermatitis research and their implications for innovative management strategies.
References
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2.Bylund S, von Kobyletzki LB, Svalstedt M, Svensson Å. Prevalence and incidence of atopic dermatitis: a systematic review. Acta dermato-venereologica. 2020 Jun 9;100(12):320-9.
3.Sibley MH, Arnold LE, Swanson JM, Hechtman LT, Kennedy TM, Owens E, Molina BS, Jensen PS, Hinshaw SP, Roy A, Chronis-Tuscano A. Variable patterns of remission from ADHD in the multimodal treatment study of ADHD. American Journal of Psychiatry. 2022 Feb;179(2):142-51.
4.Harding JL, Wander PL, Zhang X, Li X, Karuranga S, Chen H, Sun H, Xie Y, Oram RA, Magliano DJ, Zhou Z. The incidence of adult-onset type 1 diabetes: a systematic review from 32 countries and regions. Diabetes Care. 2022 Apr 1;45(4):994-1006.
5.Dong WL, An J, Yu M, Yin P, Xu TL, Liu B, Zuberbier T, Zhao ZT, Zhou MG. The prevalence and year lived with disability of atopic dermatitis in China: Findings from the global burden of disease study 2019. World Allergy Organization Journal. 2021 Nov 1;14(11):100604.
6.Nutten S. Atopic dermatitis: global epidemiology and risk factors. Annals of nutrition and metabolism. 2015 Apr 1;66(Suppl. 1):8-16.
7.Raimondo A, Lembo S. Atopic dermatitis: epidemiology and clinical phenotypes. Dermatology Practical & Conceptual. 2021 Oct;11(4).
8.Oranje AP, Glazenburg EJ, Wolkerstorfer A, De Waard‐van der Spek FB. Practical issues on interpretation of scoring atopic dermatitis: the SCORAD index, objective SCORAD and the three‐item severity score. British Journal of Dermatology. 2007 Oct 1;157(4):645-8.
9.Maiello N, Comberiati P, Giannetti A, Ricci G, Carello R, Galli E. New directions in understanding atopic march starting from atopic dermatitis. Children. 2022 Mar 23;9(4):450.
10.Ramírez‐Marín HA, Silverberg JI. Differences between pediatric and adult atopic dermatitis. Pediatric dermatology. 2022 May;39(3):345-53.
11.Crowley EL, Nezamololama N, Papp K, Gooderham MJ. Abrocitinib for the treatment of atopic dermatitis. Expert Review of Clinical Immunology. 2020 Oct 2;16(10):955-62.
12.van den Bogaard EH, Elias PM, Goleva E, Berdyshev E, Smits JP, Danby SG, Cork MJ, Leung DY. Targeting skin barrier function in atopic dermatitis. The Journal of Allergy and Clinical Immunology: In Practice. 2023 May 1;11(5):1335-46.
13.Hook G, Reinheckel T, Ni J, Wu Z, Kindy M, Peters C, Hook V. Cathepsin B gene knockout improves behavioral deficits and reduces pathology in models of neurologic disorders. Pharmacological Reviews. 2022 Jul 1;74(3):600-29.
14.Yang G, Seok JK, Kang HC, Cho YY, Lee HS, Lee JY. Skin barrier abnormalities and immune dysfunction in atopic dermatitis. International journal of molecular sciences. 2020 Apr 20;21(8):2867.
15.Korotchenko E, Schießl V, Scheiblhofer S, Schubert M, Dall E, Joubert IA, Strandt H, Neuper T, Sarajlic M, Bauer R, Geppert M. Laser‐facilitated epicutaneous immunotherapy with hypoallergenic beta‐glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma. Allergy. 2021 Jan;76(1):210-22.
16.Tokura Y, Hayano S. Subtypes of atopic dermatitis: From phenotype to endotype. Allergology International. 2022;71(1):14-24.
17.Santamaria-Babí L, Sans-de San Nicolàs L, Czarnowicki T, Akdis M, Pujol RM, Lozano-Ojalvo D, Leung D, Guttman-Yassky E, Campus SZ. CLA+ memory T cells in atopic dermatitis.
18.Sugaya M. The role of Th17-related cytokines in atopic dermatitis. International journal of molecular sciences. 2020 Feb 15;21(4):1314.
19.Jasim SY, Abdalah ME, Mshimesh BA. Role of Immune Response and Some Microbial Agents in Atopic Dermatitis Pathogenicity and Management. Pharmaceutical and Biosciences Journal. 2020 Nov 24:07-17.
20.Fania L, Moretta G, Antonelli F, Scala E, Abeni D, Albanesi C, Madonna S. Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets. International Journal of Molecular Sciences. 2022 Feb 28;23(5):2684.
21.Tanei R, Hasegawa Y. Immunological pathomechanisms of spongiotic dermatitis in skin lesions of atopic dermatitis. International Journal of Molecular Sciences. 2022 Jun 15;23(12):6682.
22.Fujii M. Current understanding of pathophysiological mechanisms of atopic dermatitis: Interactions among skin barrier dysfunction, immune abnormalities and pruritus. Biological and Pharmaceutical Bulletin. 2020 Jan 1;43(1):12-9.
23.Xiao R, Gu L, Li AM, Gan YL, He CY, Liao JX, Li YS, Xu L, Guo SL. IL-11 drives the phenotypic transformation of tracheal epithelial cells and fibroblasts to enhance abnormal repair after tracheal injury. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2023 Apr 1;1870(4):119438.
24.David BA, Kubes P. Exploring the complex role of chemokines and chemoattractants in vivo on leukocyte dynamics. Immunological reviews. 2019 May;289(1):9-30.
25.Sato M, Matsuo K, Susami Y, Yamashita A, Hayasaka H, Hara Y, Nishiwaki K, Oiso N, Kawada A, Otsuka A, Nakayama T. A CCR4 antagonist attenuates atopic dermatitis-like skin inflammation by inhibiting the recruitment and expansion of Th2 cells and Th17 cells. International Immunology. 2023 Jun 5:dxad019.
26.Chen L, Shen Z. Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders. Cellular & molecular immunology. 2020 Jan;17(1):64-75.
27.Lehman H, Gordon C. The skin as a window into primary immune deficiency diseases: atopic dermatitis and chronic mucocutaneous candidiasis. The Journal of Allergy and Clinical Immunology: In Practice. 2019 Mar 1;7(3):788-98.
28.Li D, Ainiwaer A, Zheng X, Wang M, Shi Y, Rousu Z, Hou X, Kang X, Maimaiti M, Wang H, Li J. Upregulation of LAG3 modulates the immune imbalance of CD4+ T-cell subsets and exacerbates disease progression in patients with alveolar echinococcosis and a mouse model. PLoS Pathogens. 2023 May 12;19(5):e1011396.
29.Tanei R, Hasegawa Y. Immunological pathomechanisms of spongiotic dermatitis in skin lesions of atopic dermatitis. International Journal of Molecular Sciences. 2022 Jun 15;23(12):6682.
30.Bieber T, Paller AS, Kabashima K, Feely M, Rueda MJ, Ross Terres JA, Wollenberg A. Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options. Journal of the European Academy of Dermatology and Venereology. 2022 Sep;36(9):1432-49.
31.Lim JS, Kim JY, Lee S, Choi JK, Kim EN, Choi YA, Jang YH, Jeong GS, Kim SH. Bakuchicin attenuates atopic skin inflammation. Biomedicine & Pharmacotherapy. 2020 Sep 1;129:110466.
32.Pavel P, Blunder S, Moosbrugger-Martinz V, Elias PM, Dubrac S. Atopic dermatitis: The fate of the fat. International Journal of Molecular Sciences. 2022 Feb 14;23(4):2121.
33.Notarbartolo S, Abrignani S. Human T lymphocytes at tumor sites. InSeminars in Immunopathology 2022 Nov (Vol. 44, No. 6, pp. 883-901). Berlin/Heidelberg: Springer Berlin Heidelberg.
34.Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez JV, Peng G, Yue H, Nguyen LT, Niyonsaba F. Keratinocytes: Innate immune cells in atopic dermatitis. Clinical & Experimental Immunology. 2021 Jun;204(3):296-309.
35.Staudenmaier L, Focken J, Schlatterer K, Kretschmer D, Schittek B. Bacterial membrane vesicles shape Staphylococcus aureus skin colonization and induction of innate immune responses. Experimental Dermatology. 2022 Mar;31(3):349-61.
36.Imokawa G. Cutting edge of the pathogenesis of atopic dermatitis: Sphingomyelin deacylase, the enzyme involved in its ceramide deficiency, plays a pivotal role. International Journal of Molecular Sciences. 2021 Feb 5;22(4):1613.
37.Meng J, Li Y, Fischer MJ, Steinhoff M, Chen W, Wang J. Th2 modulation of transient receptor potential channels: an unmet therapeutic intervention for atopic dermatitis. Frontiers in Immunology. 2021 Jun 30;12:696784.
38.de Vries SR, Gonzales-Wong CD. Herbal Remedies, Over-the-Counter Drugs, and Dietary Supplements: A Primer for Counselors. Professional Counselor. 2022;12(2):105-22.
39.Kalb B, Meixner L, Trendelenburg V, Unterleider N, Dobbertin-Welsch J, Heller S, Dölle-Bierke S, Roll S, Lau S, Lee Y, Fauchère F. Tolerance induction through early feeding to prevent food allergy in infants with eczema (TEFFA): rationale, study design, and methods of a randomized controlled trial. Trials. 2022 Dec;23(1):1-1.
40.Liao X, Bu Y, Jia Q. Traditional Chinese medicine as supportive care for the management of liver cancer: past, present, and future. Genes & diseases. 2020 Sep 1;7(3):370-9.
41.Tarasov AV, Rakhmanov RS. Climate and Weather: Impact on the Body. InMarine Climate of Russian Coastal Territories: Public Health Aspects of Biological Adaption 2023 May 23 (pp. 5-17). Cham: Springer International Publishing.
42.Hon KL, Leung AK, Leung TN, Lee VW. Complementary, alternative and integrative medicine for childhood atopic dermatitis. Recent Patents on Inflammation & Allergy Drug Discovery. 2017 Oct 1;11(2):114-24.
43.Hashempur MH, Ghasemi MS, Daneshfard B, Ghoreishi PS, Lari ZN, Homayouni K, Zargaran A. Efficacy of topical chamomile oil for mild and moderate carpal tunnel syndrome: A randomized double-blind placebo-controlled clinical trial. Complementary Therapies in Clinical Practice. 2017 Feb 1;26:61-7.
44.Rezapour-Firouzi S, Arefhosseini SR, Mehdi F, Mehrangiz EM, Baradaran B, Sadeghihokmabad E, Mostafaei S, Fazljou SM, Torbati MA, Sanaie S, Zamani F. Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complementary therapies in medicine. 2013 Oct 1;21(5):473-80.
45.Nakase K, Tashiro A, Yamada T, Ikoshi H, Noguchi N. Shiunko and Chuoko, topical Kampo medicines, inhibit the expression of gehA encoding the extracellular lipase in Cutibacterium acnes. The Journal of Dermatology. 2019 Apr;46(4):308-13.
46.Reuter J, Wölfle U, Weckesser S, Schempp C. Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2010 Oct;8(10):788-96.
47.Wang Z, Wang ZZ, Geliebter J, Tiwari R, Li XM. Traditional Chinese medicine for food allergy and eczema. Annals of Allergy, Asthma & Immunology. 2021 Jun 1;126(6):639-54.
48.Wang T, Liao J, Zheng L, Zhou Y, Jin Q, Wu Y. Aloe vera for prevention of radiation-induced dermatitis: a systematic review and cumulative analysis of randomized controlled trials. Frontiers in Pharmacology. 2022 Sep 29;13:976698.
49.Hon KL, Ng WG, Kung JS, Leung PC, Leung TF. Pilot studies on two complementary bath products for atopic dermatitis children: pine-tar and tea. Medicines. 2019 Jan 8;6(1):8.
50.Li Y, Li L. Contact dermatitis: classifications and management. Clinical Reviews in Allergy & Immunology. 2021 Dec;61(3):245-81.
2.Bylund S, von Kobyletzki LB, Svalstedt M, Svensson Å. Prevalence and incidence of atopic dermatitis: a systematic review. Acta dermato-venereologica. 2020 Jun 9;100(12):320-9.
3.Sibley MH, Arnold LE, Swanson JM, Hechtman LT, Kennedy TM, Owens E, Molina BS, Jensen PS, Hinshaw SP, Roy A, Chronis-Tuscano A. Variable patterns of remission from ADHD in the multimodal treatment study of ADHD. American Journal of Psychiatry. 2022 Feb;179(2):142-51.
4.Harding JL, Wander PL, Zhang X, Li X, Karuranga S, Chen H, Sun H, Xie Y, Oram RA, Magliano DJ, Zhou Z. The incidence of adult-onset type 1 diabetes: a systematic review from 32 countries and regions. Diabetes Care. 2022 Apr 1;45(4):994-1006.
5.Dong WL, An J, Yu M, Yin P, Xu TL, Liu B, Zuberbier T, Zhao ZT, Zhou MG. The prevalence and year lived with disability of atopic dermatitis in China: Findings from the global burden of disease study 2019. World Allergy Organization Journal. 2021 Nov 1;14(11):100604.
6.Nutten S. Atopic dermatitis: global epidemiology and risk factors. Annals of nutrition and metabolism. 2015 Apr 1;66(Suppl. 1):8-16.
7.Raimondo A, Lembo S. Atopic dermatitis: epidemiology and clinical phenotypes. Dermatology Practical & Conceptual. 2021 Oct;11(4).
8.Oranje AP, Glazenburg EJ, Wolkerstorfer A, De Waard‐van der Spek FB. Practical issues on interpretation of scoring atopic dermatitis: the SCORAD index, objective SCORAD and the three‐item severity score. British Journal of Dermatology. 2007 Oct 1;157(4):645-8.
9.Maiello N, Comberiati P, Giannetti A, Ricci G, Carello R, Galli E. New directions in understanding atopic march starting from atopic dermatitis. Children. 2022 Mar 23;9(4):450.
10.Ramírez‐Marín HA, Silverberg JI. Differences between pediatric and adult atopic dermatitis. Pediatric dermatology. 2022 May;39(3):345-53.
11.Crowley EL, Nezamololama N, Papp K, Gooderham MJ. Abrocitinib for the treatment of atopic dermatitis. Expert Review of Clinical Immunology. 2020 Oct 2;16(10):955-62.
12.van den Bogaard EH, Elias PM, Goleva E, Berdyshev E, Smits JP, Danby SG, Cork MJ, Leung DY. Targeting skin barrier function in atopic dermatitis. The Journal of Allergy and Clinical Immunology: In Practice. 2023 May 1;11(5):1335-46.
13.Hook G, Reinheckel T, Ni J, Wu Z, Kindy M, Peters C, Hook V. Cathepsin B gene knockout improves behavioral deficits and reduces pathology in models of neurologic disorders. Pharmacological Reviews. 2022 Jul 1;74(3):600-29.
14.Yang G, Seok JK, Kang HC, Cho YY, Lee HS, Lee JY. Skin barrier abnormalities and immune dysfunction in atopic dermatitis. International journal of molecular sciences. 2020 Apr 20;21(8):2867.
15.Korotchenko E, Schießl V, Scheiblhofer S, Schubert M, Dall E, Joubert IA, Strandt H, Neuper T, Sarajlic M, Bauer R, Geppert M. Laser‐facilitated epicutaneous immunotherapy with hypoallergenic beta‐glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma. Allergy. 2021 Jan;76(1):210-22.
16.Tokura Y, Hayano S. Subtypes of atopic dermatitis: From phenotype to endotype. Allergology International. 2022;71(1):14-24.
17.Santamaria-Babí L, Sans-de San Nicolàs L, Czarnowicki T, Akdis M, Pujol RM, Lozano-Ojalvo D, Leung D, Guttman-Yassky E, Campus SZ. CLA+ memory T cells in atopic dermatitis.
18.Sugaya M. The role of Th17-related cytokines in atopic dermatitis. International journal of molecular sciences. 2020 Feb 15;21(4):1314.
19.Jasim SY, Abdalah ME, Mshimesh BA. Role of Immune Response and Some Microbial Agents in Atopic Dermatitis Pathogenicity and Management. Pharmaceutical and Biosciences Journal. 2020 Nov 24:07-17.
20.Fania L, Moretta G, Antonelli F, Scala E, Abeni D, Albanesi C, Madonna S. Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets. International Journal of Molecular Sciences. 2022 Feb 28;23(5):2684.
21.Tanei R, Hasegawa Y. Immunological pathomechanisms of spongiotic dermatitis in skin lesions of atopic dermatitis. International Journal of Molecular Sciences. 2022 Jun 15;23(12):6682.
22.Fujii M. Current understanding of pathophysiological mechanisms of atopic dermatitis: Interactions among skin barrier dysfunction, immune abnormalities and pruritus. Biological and Pharmaceutical Bulletin. 2020 Jan 1;43(1):12-9.
23.Xiao R, Gu L, Li AM, Gan YL, He CY, Liao JX, Li YS, Xu L, Guo SL. IL-11 drives the phenotypic transformation of tracheal epithelial cells and fibroblasts to enhance abnormal repair after tracheal injury. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2023 Apr 1;1870(4):119438.
24.David BA, Kubes P. Exploring the complex role of chemokines and chemoattractants in vivo on leukocyte dynamics. Immunological reviews. 2019 May;289(1):9-30.
25.Sato M, Matsuo K, Susami Y, Yamashita A, Hayasaka H, Hara Y, Nishiwaki K, Oiso N, Kawada A, Otsuka A, Nakayama T. A CCR4 antagonist attenuates atopic dermatitis-like skin inflammation by inhibiting the recruitment and expansion of Th2 cells and Th17 cells. International Immunology. 2023 Jun 5:dxad019.
26.Chen L, Shen Z. Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders. Cellular & molecular immunology. 2020 Jan;17(1):64-75.
27.Lehman H, Gordon C. The skin as a window into primary immune deficiency diseases: atopic dermatitis and chronic mucocutaneous candidiasis. The Journal of Allergy and Clinical Immunology: In Practice. 2019 Mar 1;7(3):788-98.
28.Li D, Ainiwaer A, Zheng X, Wang M, Shi Y, Rousu Z, Hou X, Kang X, Maimaiti M, Wang H, Li J. Upregulation of LAG3 modulates the immune imbalance of CD4+ T-cell subsets and exacerbates disease progression in patients with alveolar echinococcosis and a mouse model. PLoS Pathogens. 2023 May 12;19(5):e1011396.
29.Tanei R, Hasegawa Y. Immunological pathomechanisms of spongiotic dermatitis in skin lesions of atopic dermatitis. International Journal of Molecular Sciences. 2022 Jun 15;23(12):6682.
30.Bieber T, Paller AS, Kabashima K, Feely M, Rueda MJ, Ross Terres JA, Wollenberg A. Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options. Journal of the European Academy of Dermatology and Venereology. 2022 Sep;36(9):1432-49.
31.Lim JS, Kim JY, Lee S, Choi JK, Kim EN, Choi YA, Jang YH, Jeong GS, Kim SH. Bakuchicin attenuates atopic skin inflammation. Biomedicine & Pharmacotherapy. 2020 Sep 1;129:110466.
32.Pavel P, Blunder S, Moosbrugger-Martinz V, Elias PM, Dubrac S. Atopic dermatitis: The fate of the fat. International Journal of Molecular Sciences. 2022 Feb 14;23(4):2121.
33.Notarbartolo S, Abrignani S. Human T lymphocytes at tumor sites. InSeminars in Immunopathology 2022 Nov (Vol. 44, No. 6, pp. 883-901). Berlin/Heidelberg: Springer Berlin Heidelberg.
34.Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez JV, Peng G, Yue H, Nguyen LT, Niyonsaba F. Keratinocytes: Innate immune cells in atopic dermatitis. Clinical & Experimental Immunology. 2021 Jun;204(3):296-309.
35.Staudenmaier L, Focken J, Schlatterer K, Kretschmer D, Schittek B. Bacterial membrane vesicles shape Staphylococcus aureus skin colonization and induction of innate immune responses. Experimental Dermatology. 2022 Mar;31(3):349-61.
36.Imokawa G. Cutting edge of the pathogenesis of atopic dermatitis: Sphingomyelin deacylase, the enzyme involved in its ceramide deficiency, plays a pivotal role. International Journal of Molecular Sciences. 2021 Feb 5;22(4):1613.
37.Meng J, Li Y, Fischer MJ, Steinhoff M, Chen W, Wang J. Th2 modulation of transient receptor potential channels: an unmet therapeutic intervention for atopic dermatitis. Frontiers in Immunology. 2021 Jun 30;12:696784.
38.de Vries SR, Gonzales-Wong CD. Herbal Remedies, Over-the-Counter Drugs, and Dietary Supplements: A Primer for Counselors. Professional Counselor. 2022;12(2):105-22.
39.Kalb B, Meixner L, Trendelenburg V, Unterleider N, Dobbertin-Welsch J, Heller S, Dölle-Bierke S, Roll S, Lau S, Lee Y, Fauchère F. Tolerance induction through early feeding to prevent food allergy in infants with eczema (TEFFA): rationale, study design, and methods of a randomized controlled trial. Trials. 2022 Dec;23(1):1-1.
40.Liao X, Bu Y, Jia Q. Traditional Chinese medicine as supportive care for the management of liver cancer: past, present, and future. Genes & diseases. 2020 Sep 1;7(3):370-9.
41.Tarasov AV, Rakhmanov RS. Climate and Weather: Impact on the Body. InMarine Climate of Russian Coastal Territories: Public Health Aspects of Biological Adaption 2023 May 23 (pp. 5-17). Cham: Springer International Publishing.
42.Hon KL, Leung AK, Leung TN, Lee VW. Complementary, alternative and integrative medicine for childhood atopic dermatitis. Recent Patents on Inflammation & Allergy Drug Discovery. 2017 Oct 1;11(2):114-24.
43.Hashempur MH, Ghasemi MS, Daneshfard B, Ghoreishi PS, Lari ZN, Homayouni K, Zargaran A. Efficacy of topical chamomile oil for mild and moderate carpal tunnel syndrome: A randomized double-blind placebo-controlled clinical trial. Complementary Therapies in Clinical Practice. 2017 Feb 1;26:61-7.
44.Rezapour-Firouzi S, Arefhosseini SR, Mehdi F, Mehrangiz EM, Baradaran B, Sadeghihokmabad E, Mostafaei S, Fazljou SM, Torbati MA, Sanaie S, Zamani F. Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complementary therapies in medicine. 2013 Oct 1;21(5):473-80.
45.Nakase K, Tashiro A, Yamada T, Ikoshi H, Noguchi N. Shiunko and Chuoko, topical Kampo medicines, inhibit the expression of gehA encoding the extracellular lipase in Cutibacterium acnes. The Journal of Dermatology. 2019 Apr;46(4):308-13.
46.Reuter J, Wölfle U, Weckesser S, Schempp C. Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2010 Oct;8(10):788-96.
47.Wang Z, Wang ZZ, Geliebter J, Tiwari R, Li XM. Traditional Chinese medicine for food allergy and eczema. Annals of Allergy, Asthma & Immunology. 2021 Jun 1;126(6):639-54.
48.Wang T, Liao J, Zheng L, Zhou Y, Jin Q, Wu Y. Aloe vera for prevention of radiation-induced dermatitis: a systematic review and cumulative analysis of randomized controlled trials. Frontiers in Pharmacology. 2022 Sep 29;13:976698.
49.Hon KL, Ng WG, Kung JS, Leung PC, Leung TF. Pilot studies on two complementary bath products for atopic dermatitis children: pine-tar and tea. Medicines. 2019 Jan 8;6(1):8.
50.Li Y, Li L. Contact dermatitis: classifications and management. Clinical Reviews in Allergy & Immunology. 2021 Dec;61(3):245-81.
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Feb 14, 2024
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Muhammad Osama Alam, Muhammad Noman Khan, Sheraz Muhammad Siddiqui, Taseer Ahmed Khan, & Safila Naveed. (2024). NEW INSIGHTS INTO SAFE AND EFFECTIVE MANAGEMENT OF DERMATITIS WITH POLYHERBAL FORMULATION. Journal of Population Therapeutics and Clinical Pharmacology, 31(2), 668-679. https://doi.org/10.53555/jptcp.v31i2.4144
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Author Biographies
Muhammad Osama Alam
Faculty of Eastern Medicine, Hamdard University, Karachi, 74600, Pakistan
Muhammad Noman Khan
Faculty of Eastern Medicine, Hamdard University, Karachi, 74600, Pakistan
Sheraz Muhammad Siddiqui
Faculty of Eastern Medicine, Hamdard University, Karachi, 74600, Pakistan
Taseer Ahmed Khan
Department of Physiology, University of Karachi, Karachi, 75270, Pakistan
Safila Naveed
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, 75270, Pakistan
How to Cite
Muhammad Osama Alam, Muhammad Noman Khan, Sheraz Muhammad Siddiqui, Taseer Ahmed Khan, & Safila Naveed. (2024). NEW INSIGHTS INTO SAFE AND EFFECTIVE MANAGEMENT OF DERMATITIS WITH POLYHERBAL FORMULATION. Journal of Population Therapeutics and Clinical Pharmacology, 31(2), 668-679. https://doi.org/10.53555/jptcp.v31i2.4144