FORMULATION AND EVALUATION OF NIOSOMAL SUSPENSION OF TELMISARTAN
Main Article Content
Keywords
Telmisartan, niosomal suspensions, Span 60, cholesterol, factorial design, thin film hydration method, drug release, stability.
Abstract
This study successfully formulated niosomal suspensions of Telmisartan by optimizing the concentrations of Span 60 and cholesterol using a factorial design. This strategic approach allowed for systematic variation and analysis, leading to the identification of optimal concentrations that enhanced formulation effectiveness. Niosomal formulations with higher concentrations of Span 60 and cholesterol demonstrated controlled drug release and improved stability, which are essential for maintaining consistent therapeutic effects and potentially reducing dosing frequency, thereby improving patient compliance.
The thin film hydration method used to prepare niosomes consistently produced reliable and reproducible formulations, highlighting its suitability for pharmaceutical development. The enhanced stability and controlled release properties of the optimized niosomal formulations suggest their potential for further pharmaceutical development. These formulations can maintain a consistent drug release profile, enhancing the therapeutic efficacy of Telmisartan and offering significant benefits in terms of patient compliance and treatment outcomes.
In conclusion, this study underscores the promising potential of niosomal systems as carriers for Telmisartan. The successful optimization of niosomal formulations via factorial design and the consistent preparation using the thin film hydration method highlight the feasibility and effectiveness of this approach. These findings pave the way for further research and development, aiming to fully exploit the potential of niosomal suspensions in enhancing the delivery and efficacy of Telmisartan in pharmaceutical applications.
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Ms. Vaishnavi Pandey
Research Scholar, Kipm College Gida Gorakhpur
Mr. D K.V Vishwakarma
Head Of Department, Kipm College Gida Gorakhpur
Dr. J.N Mishra
DIRECTOR, Kipm College Gida Gorakhpur