FORMULATION AND EVALUATION OF CARBAMAZEPINE ORO DISPERSIBLE TABLET USING LOCUST BEAN GUM
Main Article Content
Keywords
Orally disintegrating tablets (ODTs), epilepsy treatment, locust bean gum (LBG), natural disintegrant, factorial design, croscarmellose sodium, Crospovidone, drug release rates.
Abstract
This study has advanced the development of orally disintegrating tablets (ODTs) for epilepsy treatment by leveraging locust bean gum (LBG) as a natural disintegrant. The research employed a factorial design framework to assess nine distinct formulations, including various disintegrants like croscarmellose sodium and Crospovidone, to evaluate their efficacy against LBG. Formulation F3 was identified as the optimal formulation, achieving the most favorable balance across all evaluation parameters.
Formulation F3 demonstrated superior performance with rapid disintegration and improved drug release rates, outperforming other formulations that used synthetic disintegrants. Additionally, F3 exhibited significantly lower residual moisture content, enhancing tablet stability. These findings highlight the potential of LBG as an effective natural alternative in ODT formulations, offering a promising and patient-friendly solution for epilepsy management.
The study also emphasizes the successful application of factorial design in optimizing pharmaceutical formulations, showcasing the importance of rigorous methodologies in drug development. The promising results of using LBG in ODTs for epilepsy treatment may inspire further research and development, leading to more natural and sustainable alternatives in pharmaceutical formulations.
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3. "Theory and Practice of Tablet Formulation" by Michael E. Aulton, Elsevier, Fourth Edition, pages 443-450.
4. "Oral Drug Delivery: Formulation and Clinical Considerations" by Ecevit Bilensoy, Springer, 2016 Edition, pages 245-269.
5. "Fast-Dispersing Dosage Forms" by Yan V. Sun and Zhiqiang Liu, CRC Press, First Edition, pages 125-147.
6. "Pharmaceutical Dosage Forms: Disperse Systems" by Herbert A. Lieberman, Martin M. Rieger, and Gilbert S. Banker, CRC Press, Second Edition, pages 183-210.
7. "Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form" by Mark Gibson, CRC Press, Second Edition, pages 501-524.
8. "Drug Delivery: Principles and Applications" by Binghe Wang, Teruna Siahaan, and Richard Soltero, Wiley, Second Edition, pages 275-300.
9. "Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm" by Ajit S. Narang and Sherif I.F. Badawy, Elsevier, 2018 Edition, pages 601-625.
10. "Modern Pharmaceutics" by Alexander T. Florence and Juergen Siepmann, CRC Press, Fifth Edition, pages 345-368.
11. "Pharmaceutics: The Science of Dosage Form Design" by Michael E. Aulton, Churchill Livingstone, Second Edition, pages 234-256.
12. "Drug Delivery Systems" by Vasant V. Ranade and Mannfred A. Hollinger, CRC Press, Third Edition, pages 485-508.
13. "Introduction to the Pharmaceutical Sciences" by Nita K. Pandit, Lippincott Williams & Wilkins, 2007 Edition, pages 326-348.
14. "Fundamentals of Pharmaceutical and Biologics Regulations" by Howard C. Ansel, Lea &Febiger, 2010 Edition, pages 178-202.
15. "Pharmaceutical Calculations" by Howard C. Ansel and Shelly J. Prince, Lippincott Williams & Wilkins, Thirteenth Edition, pages 78-99.
16. "Encyclopedia of Pharmaceutical Technology" by James Swarbrick, Informa Healthcare, Third Edition, pages 1650-1674.
17. "Pharmaceutical Formulation Development of Peptides and Proteins" by Lars Hovgaard, Sven Frokjaer, and Marco van de Weert, CRC Press, Second Edition, pages 295-319.
18. "Biopharmaceutics Applications in Drug Development" by Rajesh Krishna, Springer, 2008 Edition, pages 150-173.
19. "Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems" by Loyd V. Allen Jr., Nicholas G. Popovich, and Howard C. Ansel, Lippincott Williams & Wilkins, Ninth Edition, pages 426-450.
20. "Controlled Drug Delivery: Fundamentals and Applications" by Joseph R. Robinson and Vincent H. L. Lee, CRC Press, Second Edition, pages 527-550.
21. "Goodman & Gilman's: The Pharmacological Basis of Therapeutics" by Laurence L. Brunton, Randa Hilal-Dandan, and Bjorn Knollmann, McGraw-Hill Education, 13th Edition, pages 583-615.
22. "Rang & Dale's Pharmacology" by James M. Ritter, Rod J. Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, and Humphrey P. Rang, Elsevier, 9th Edition, pages 467-486.
23. "Basic and Clinical Pharmacology" by Bertram Katzung, Anthony Trevor, McGraw-Hill Education, 14th Edition, pages 363-388.
24. "Pharmacotherapy: A Pathophysiologic Approach" by Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, and L. Michael Posey, McGraw-Hill Education, 10th Edition, pages 929-950.
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31. "Modern Pharmacology with Clinical Applications" by Charles R. Craig and Robert E. Stitzel, Lippincott Williams & Wilkins, 6th Edition, pages 379-405.
32. "Applied Therapeutics: The Clinical Use of Drugs" by Mary Anne Koda-Kimble, Lloyd Yee Young, B. Joseph Guglielmo, Wayne A. Kradjan, and R. Rebecca Alldredge, Lippincott Williams & Wilkins, 10th Edition, pages 1025-1051.
33. "CNS Neurotransmitters and Neuromodulators: Glutamate" by Trevor W. Stone, CRC Press, 1st Edition, pages 217-238.
34. "The Comprehensive Evaluation and Treatment of Epilepsy" by Steven C. Schachter, Donald L. Schomer, and Joseph T. Devinsky, Academic Press, 1st Edition, pages 145-178.
35. "Antiepileptic Drugs: A Clinician's Manual" by Ali A. Asadi-Pooya and Michael R. Sperling, Oxford University Press, 1st Edition, pages 89-115.
36. "Neuropharmacology: Methods and Protocols" by James T. Barrett, Humana Press, 1st Edition, pages 395-417.
37. "The Pharmacology of Functional, Biochemical, and Molecular Aspects of CNS Proteins" by Sidney B. Wallace and David R. Brown, Springer, 1st Edition, pages 123-145.
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39. "Drug Metabolism and Pharmacokinetics in Drug Discovery: A Primer for Bioanalytical Chemists, Part II" by Donglu Zhang, Rodney F. Prelusky, and Larry D. Sasso, John Wiley & Sons, 1st Edition, pages 231-254.
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41. "Orally Disintegrating Tablets: A Review" by S. Kaushik and R. Kumar, International Journal of Pharmaceutical Sciences and Drug Research, 2010, pages 74-80.
42. "Formulation Strategies for Orally Disintegrating Tablets: A Review with Current Insights" by N. Priyanka and K. S. V. Krishna Rao, Research Journal of Pharmacy and Technology, 2021, pages 2149-2155.
43. "Orally Disintegrating Tablets: Formulation, Preparation Techniques, and Evaluation" by A. K. Patil, R. H. Tambe, and D. B. Koli, Journal of Drug Delivery and Therapeutics, 2019, pages 412-421.
44. "Recent Advances in Orally Disintegrating Tablet Technology: A Review" by N. A. Chivate, P. A. Pagar, and D. P. Dandge, International Journal of Pharmaceutical Research and Allied Sciences, 2017, pages 1-11.
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46. "Orally Disintegrating Tablets: Formulation, Preparation Techniques and Evaluation" by P. R. Gajra, S. K. Godbole, and P. R. S. Babu, Journal of Drug Delivery and Therapeutics, 2020, pages 315-323.
47. "Formulation and Evaluation of Orally Disintegrating Tablets: A Review" by N. G. R. Rao, M. G. Rajan, and P. R. Mohan, Journal of Pharmaceutical Sciences and Research, 2019, pages 3167-3176.
48. "Emerging Trends in Orally Disintegrating Tablets: A Review" by A. K. Singh, S. K. Dubey, and S. K. Jha, Research Journal of Pharmacy and Technology, 2020, pages 1851-1857.
49. "Oral Disintegrating Tablets: An Overview of Formulation Techniques" by R. M. Sangave, S. B. Bari, and S. J. Wadher, International Journal of Pharmaceutical and Chemical Sciences, 2013, pages 265-272.
50. "Recent Trends in Orally Disintegrating Tablets: An Overview" by S. S. Rajput, P. D. Chaudhari, and P. R. Vavia, Journal of Drug Delivery and Therapeutics, 2012, pages 145-153.
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Jul 30, 2024
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Mr. Saurabh Mishra, Mr. Amit Kumar Shukla, & Dr. J.N Mishra. (2024). FORMULATION AND EVALUATION OF CARBAMAZEPINE ORO DISPERSIBLE TABLET USING LOCUST BEAN GUM. Journal of Population Therapeutics and Clinical Pharmacology, 31(7), 1514-1536. https://doi.org/10.53555/jptcp.v31i7.7305
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Author Biographies
Mr. Saurabh Mishra
Research Scholar, Kipm College Gida Gorakhpur
Mr. Amit Kumar Shukla
Associate Professor, Kipm College Gida Gorakhpur
Dr. J.N Mishra
Director, Kipm College Gida Gorakhpur
How to Cite
Mr. Saurabh Mishra, Mr. Amit Kumar Shukla, & Dr. J.N Mishra. (2024). FORMULATION AND EVALUATION OF CARBAMAZEPINE ORO DISPERSIBLE TABLET USING LOCUST BEAN GUM. Journal of Population Therapeutics and Clinical Pharmacology, 31(7), 1514-1536. https://doi.org/10.53555/jptcp.v31i7.7305