DUCTAL ECTASIA IN SYNDROMIC CONTEXTS: A COMPARATIVE META-ANALYSIS OF CLINICAL FEATURES IN NEUROFIBROMATOSIS TYPE 1, COWDEN SYNDROME, AND PEUTZ-JEGHERS SYNDROME
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Abstract
Background: Ductal ectasia is frequently observed in various syndromic contexts, including Neurofibromatosis Type 1 (NF1), Cowden Syndrome, and Peutz-Jeghers Syndrome. The clinical features of ductal ectasia can vary significantly among these syndromes.
Objective: To compare the clinical features of ductal ectasia in patients with NF1, Cowden Syndrome, and Peutz-Jeghers Syndrome through a systematic review and meta-analysis.
Methods: A comprehensive literature search was conducted in PubMed, EMBASE, and Cochrane Library databases. Studies were selected based on predefined inclusion criteria, focusing on patients diagnosed with ductal ectasia in the context of NF1, Cowden Syndrome, and Peutz-Jeghers Syndrome. Data were extracted and analyzed for prevalence, clinical presentation, and complications.
Results: The analysis included 20 studies, encompassing 1,200 patients. Significant differences were observed in the prevalence, clinical presentation, and complications of ductal ectasia among the three syndromes.
Conclusion: Ductal ectasia presents with distinct clinical features in NF1, Cowden Syndrome, and Peutz-Jeghers Syndrome, underscoring the need for tailored diagnostic and management approaches
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Dr Hashim Mahmood
University of Lahore Teaching Hospital, University College of Medicine and Dentistry, LahoreDr Usama Zahid Raja
Shifa College of Medicine, Islamabad, PakistanAlian Fatima
RAK Medical and Health Sciences University, RAK, UAEDr Urfa Mahmood
University College of Medicine and Dentistry, UOL, LahoreDr Basma Jawed
Medical School, Services Institute of Medical Sciences, LahoreDr Wahaj Naeem
Shifa International Hospital, Islamabad, Pakistan
Dana Al Tarawneh
RAK Medical and Health Sciences University, RAK, UAE
Dr Ashtar Kariem
Post Graduate Clinical Trainee under SGH, UAE
Dr Nimra Riaz
Department of Medicine, PAEC Islamabad, Pakistan