FLOW INJECTION DETERMINATION OF PARACETAMOL IN PHARMACEUTICAL FORMULATIONS USING LUMINOL – DIPERIODATOARGENTATE (III) SYSTEM WITH CHEMILUMINESCENCE DETECTION
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Keywords
Flow injection, chemiluminescence, luminol, diperiodatoargentate (DPA), tablets
Abstract
A simple flow injection-chemiluminescence (FI-CL) method has been developed for the rapid and sensitive detection of paracetamol (PCM) in pharmaceutical formulations. Utilizing luminol-diperiodatoargentate (III) (DPA) system and optimizing all parameters, we attained an effective linearity range of 0.075-0.75 mg L-1, with a coefficient of determination (R2) of 0.9999. The method showed a limit of detection (LOD) of 7 × 10-4 mg L-1, a limit of quantification (LOQ) of 2 × 10-3 mg L-1, and relative standard deviations (RSDs) ranging from 0.3-1.1%, which indicated high precision. Furthermore, the method achieved a high injection throughput of 120 h-1, which showed it was suitable for real-world applications. Validation through comparison with a reported FI-CL method using the paired Student's t-test shown no significant differences at the 95% confidence level, and the method was successfully applied to determine PCM in pharmaceutical tablets.
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Abdul Hakeem
Faculty of Basic Sciences, Department of Chemistry, University of Balochistan, Quetta, Pakistan
Naqeebullah Khan
Faculty of Basic Sciences, Department of Chemistry, University of Balochistan, Quetta, Pakistan
Rehana Kamal
Gynecology Department, Bolan University of Medical and Health Sciences Quetta, Balochistan, Pakistan
Attiq-Ur-Rehman Kakar
Faculty of Basic Sciences, Department of Chemistry, University of Balochistan, Quetta, Pakistan
Samiullah
Faculty of Basic Sciences, Department of Chemistry, University of Balochistan, Quetta, Pakistan
Habiba Taj
Faculty of Basic Sciences, Department of Chemistry, University of Balochistan, Quetta, Pakistan
Khair Un Nisa
Faculty of Basic Sciences, Department of Chemistry, University of Balochistan, Quetta, Pakistan