EVALUATION OF ANTI-DIABETIC, ANTI-EPILEPTIC AND CARDIO PROTECTIVE ACTIVITIES BERCHEMIA PAKISTANICA
Main Article Content
Keywords
Anti-diabetic, Anti-epileptic, Cardioprotective, Berchemia pakistanica
Abstract
Berchemia pakistanica is a medicinal plant of Balochistan, used for treatment of various diseases intraditional medicine. In current study, preliminary phytochemical tests, FT-IR studies, determinationof the heavy metal concentrations, acute toxicity, anti-diabetic, anti-epileptic and cardioprotectiveactivitieswereevaluated.Inpreliminaryphytochemicaltests,alkaloids,saponins,flavonoids,glycosides, Terpenoids and tannins were present. In FT-IR studies presence of various functionalgroups were confirmed. The concentration of Se, Cr, Co, Sb and Mn were within the permitted limit.Up to dose of 5000 mg/kg B. pakistanica did not showed any sign of toxicity. B. pakistanica ethanolextractshowedsignificant(p<0.05)anti-diabeticeffectsandalloxaninduceddiabetes.B.pakistanicaethanol extract also showed significant (p<0.05) anti-epileptic effects in strychnine and picrotoxininducedanti-convulsantactivity.InCardioprotectiveactivityB.pakistanicaethanolextractproducedsignificant (p<0.05) protective effects. It is concluded that B. pakistanica showed significant anti-diabetic, anti-epileptic and cardioprotective activities and can be used as an alternative drug formanagementofEpilepsy,diabetes and asan cardioprotectiveagent.
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Abdul Jabbar
Department of Pharmacognosy, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan
Iqbal Azhar
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan
Shafi Muhammad
Department of Pharmacognosy, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan
Shahlla Imam
Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi
Mohammad Arslan
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan
Nagina Soomer Khan
Department of Eastern Medicine, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan
Nisar Ahmad Shahwani
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan
Muhammad Younis
Department of Pharmacology, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan
Ghulam Mustafa
Department of Pharmaceutics, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan
Abdul Qadir
Department of Pharmaceutics, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan