FORMULATION DEVELOPMENT OF SUSTAINED RELEASE ANTIULCER DRUG AND STUDY OF PRE-FORMULATION PARAMETERS AND ITS CHARACTERIZATION
Main Article Content
Keywords
Sustained Release, Antiulcer, Nizatidine, Pre-formulation, characterization
Abstract
The aim of present study was to formulate and developed sustained release tablets of Nizatidine (220 mg) by varying concentration of polymers like chitosan, Kollidon SR and HPMC K100M by wet granulation technique. The pre-formulation parameters were studied like melting point of drug, FTIR study and DSC analysis of drug. Various pre-compression parameters were evaluated like Bulk density, Tapped Density, Carr’ Index, Angle of repose. This study revealed the idea about how the concentration of polymers affects pre-compression parameters of the drug formulation.
References
2. Loyd V. Allen, Howard, C. Anesel (2016) Ansel’s Pharmaceutical Dosage for and Drug Delivery Systems,9 ed: Lippincott Williams & Wilkins.
3. Kapil, Parshant Patil, Salil Pawar AJPTR (2016) A basic approach on Sustained Relese Drug Delivery System.
4. Syed Iftequar, Maria Saifee, Lahoti Swaroop, Zahid Zaheer (2016) Formulation amd evaluation of Floting drug delivery System of Ramipril. JIPBS 86.
5. Surnthra K. Gunatilake, S, S. Samaratunga and Folahan (2016) Effect of binder on the physico-chemical properties and the quamtity of paracetamol tablets. Der Pharamachemica 237-38.
6. Veego, VMP-D India, Instruction manual.
7. R Motukuri et al. Development and Evaluation of Gastric Retentive Floating Tablets of Nizatidine. International Journal of Pharmaceutical Research And Bio-Science. 2014, 3,252-276.
8. Motukuri R, Nagesh P, Development And Evaluation Of Gastric Retentive Floating Tablets Of Nizatidine, IJPRBS, 2014; Volume 3(1): 252-276
9. Jain AK, Jain CP, Gaur K, Kakde A, Meena M, et al. (2009) Effect of natural biodegradable and synthetic polymer for gastric disease by floating microballons. Continental J Pharm Sci 3: 1-6. Link: https://bit.ly/32ZBYxi
10. Jain AK, Jain CP, Tanwar YS, Naruka PS (2009) Formulation, characterization and in vitro evaluation of floating microballons of famotidine as a gastro retentive dosage form. Asi J of Pharmac 3: 222-226. Link: https://bit.ly/3f57AUz
11. Trivedi, N D., Trivedi, U N., Patel, M M., Patel, J K., Bhandari, A. Preparation and evaluation of floating matrix tablet of ranitidine ,American Journal of Drug Discovery and Development. 2011;1(1):8-23.
12. Irene, N., Sasikanth, K., Preparation and in vitro evaluation of rosiglitazone maleate bi layered bioadhesive floating tablets. J. Chem. Pharm. Res. 2011; 3(4):140-149.
13. Ghosh, Santanu & Barik, Bhakti Bhusan. (2009). Preparation and evaluation of aceclofenac sustained release formulation and comparison of formulated and marketed product. International Journal of Medicine and Medical Sciences. 1. 375-382.
14. Shanmugam S, Srivastav A, Vetrichelvan, “Formulation and Evaluation of Sustained Release Matrix Tablets of Venlafaxine Hydrochloride.” 1:(5) 506-510, 2013.
15. Kalpana Patle, Mithun Bhowmick, Jagdish Rathi.“Formulation and Evaluation of Monolithic Matrix Transdermal therapeutic system of vildagliptin using polymer Eudragit RSPO and RLPO.6:(2), 50-61,2018.
16. Kumar, Pradeep & Kumar, Sachin. (2020). Formulation And Evaluation Of Sustained Release Matirx Tablet Of Vildagliptin Using Natural And Synthetic Polymers.
17. Suman Gehlot & Sumeet Dwivedi, 2017. "Design, Development and Characterization of Sustain Release Matrix Type Tablet of Cinnarazine," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 1(5), pages 1446-1452, October.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Satbir Singh
Research Scholar, Department of Pharmacy, Sunrise University, Alwar, Rajasthan
Dr. Gaikwad Dushyant Dadabhau
Professor, Department of Pharmacy, Sunrise University, Alwar, Rajasthan
Kehar Singh
Research Scholar, Department of Pharmacy, Sunrise University, Alwar, Rajasthan