VARIATION PROFILE OF SERUM CALCIUM IN PATIENTS SUFFERING FROM PULMONARY TUBERCULOSIS
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Keywords
Pulmonary Tuberculosis, Biochemical parameters, serum calcium
Abstract
Background Pulmonary Tuberculosis is a serious global health issue that has a significant influence on public health systems all over the world.
Aims and Objectives: This study investigates the variation profile in serum calcium alterations associated with pulmonary tuberculosis (TB) caused by Mycobacterium in a Pakistani population. Study carried in Institute of Biochemistry University of Sindh Jamshoro in collaboration with Chest Centre disease Kotri, Indus hospital and Civil Hospitals respectively, samples were collected from Pulmonology wards of respective hospitals, from December 2022 to June 2023.
Methods A retrospective case control study comprises total 200 participants, randomly selected 100 subjects of pulmonary tuberculosis and 100 age and gender matched healthy non T.B controls were analyzed for demographic characteristics of the patients and determination of calcium profile in PTB patients. Statistical analysis was done on SPSS software.
Results The detailed analysis of serum Calcium with Pulmonary Tuberculosis presents as calcium level mean ± SD 8.95 + 0.77 than in controls mean ± SD 9.49 + 0.81, with a p-value of 0.000, showing results are statically significant.
Conclusion we have observed altered biochemical abnormalities such as hypocalcaemia, serum calcium levels were observed significantly low in TB patients as compare to healthy controls. This study may contribute to the development of improved diagnostic and monitoring tools for TB patients, facilitating early detection and effective disease management.
References
2. Barry 3rd, C.E., et al., The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nature Reviews Microbiology, 2009. 7(12): p. 845-855.
3. Arcila, M.L., et al., Activation of apoptosis, but not necrosis, during Mycobacterium tuberculosis infection correlated with decreased bacterial growth: role of TNF-α, IL-10, caspases and phospholipase A2. Cellular immunology, 2007. 249(2): p. 80-93.
4. Bandyopadhyay, A., et al., COVID-19 and tuberculosis co-infection: a neglected paradigm. Monaldi Archives for Chest Disease, 2020. 90(3).
5. Ahmed, N. and S.E. Hasnain, Molecular epidemiology of tuberculosis in India: Moving forward with a systems biology approach. Tuberculosis, 2011. 91(5): p. 407-413.
6. Nogueira, B.M., et al., Diagnostic biomarkers for active tuberculosis: progress and challenges. EMBO Molecular Medicine, 2022. 14(12): p. e14088.
7. Behera, D., Textbook of Pulmonary Medicine Volumes 1 and 2. 2010: Jaypee Brothers Pvt. Limited.
8. Russell, D.G., Mycobacterium tuberculosis: here today, and here tomorrow. Nature reviews Molecular cell biology, 2001. 2(8): p. 569-578.
9. Gordon, S.V. and T. Parish, Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe. Microbiology, 2018. 164(4): p. 437-439.
10. Fu, L. and C. Fu-Liu, Is Mycobacterium tuberculosis a closer relative to Gram-positive or Gram–negative bacterial pathogens? Tuberculosis, 2002. 82(2-3): p. 85-90.
11. Travis, W.D., et al., Introduction to the 2015 World Health Organization classification of tumors of the lung, pleura, thymus, and heart. Journal of Thoracic Oncology, 2015. 10(9): p. 1240-1242.
12. Organization, W.H., Global tuberculosis report 2013. 2013: World Health Organization.
13. Kontsevaya, I., et al., Update on the diagnosis of tuberculosis. Clinical Microbiology and Infection, 2023.
14. Society, A.T., Diagnostic standards and classification of tuberculosis in adults and children. Am J Respir Crit Care Med., 2000. 161: p. 1376-1395.
15. Trimble, W.S. and S. Grinstein, TB or not TB: calcium regulation in mycobacterial survival. Cell, 2007. 130(1): p. 12-14.
16. Schenck, P.A., et al., Disorders of calcium: hypercalcemia and hypocalcemia. Fluid, electrolyte, and acid-base disorders in small animal practice, 2006. 4: p. 120-94.
17. Li, M., et al., Evaluation of the Cepheid 3-gene host response blood test for tuberculosis diagnosis and treatment response monitoring in a primary-level clinic in rural China. Journal of Clinical Microbiology, 2023. 61(11): p. e00911-23.
18. Katsoulos, P., et al., Serum calcium determination with atomic absorption spectrophotometry and colorimetric method: association and predictive equations between them in cattle and sheep samples. Comparative Clinical Pathology, 2021. 30(1): p. 11-15.
19. Loupy, A., et al., PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor. The Journal of clinical investigation, 2012. 122(9): p. 3355-3367.
20. Rohini, K., et al., Assessment of serum calcium and phosphorus in pulmonary tuberculosis patients before, during and after chemotherapy. Indian Journal of Clinical Biochemistry, 2014. 29: p. 377-381.
21. Memon, Z.M., A.M. Shah, and T. Kazi, Study of calcium in active pulmonary tuberculosis patients by flame atomic absorption spectrophotometer. Indo American Journal of harm Research, 2014. 4(11).
22. Sales, A.C.d.S., et al., Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period. Journal of Clinical Medicine, 2023. 12(14): p. 4843.
23. Dosumu, E. and J. Momoh, Hypercalcemia in patients with newly diagnosed tuberculosis in Abuja, Nigeria. Canadian respiratory journal, 2006. 13: p. 83-87.
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Saad un Nisa Mahesar
M.phil scholar, Institute of Biochemistry University of Sindh Jamshoro
Mahvish jabeen Channa
Asst. Prof. University of Sindh Jamshoro
Beenish Khanzada
Asst. Prof. University of Sindh Jamshoro
Shagufta jabeen
Institute of Microbiology University of Sindh Jamshoro
Jennica Rose
Institute of Biochemistry, University of Sindh Jamshoro
Autif Hussain Mangi
Asst. Prof. University of Sindh Jamshoro Sindh Pakistan
Shah Muhammad Mahesar
Prof. Dean IBN-E-SINA university Mirpurkhas