THE UP-REGULATED CUL7 GENE IS ASSOCIATED WITH PATHOGENESIS, METASTASIS, AND LOW SURVIVAL RATES IN LIVER HEPATOCELLULAR CARCINOMA PATIENTS
Main Article Content
Keywords
CUL7, LIHC, Metastasis, Prognosis
Abstract
The investigation focused on exploring the role of CUL7 genes in Liver Hepatocellular Carcinoma (LIHC) development and progression. Utilizing the UALCAN database, a significant up-regulation of CUL7 expression was observed in LIHC tissues, suggesting its potential involvement in the development of LIHC. Subsequent analysis across various clinical parameters revealed consistent up-regulation of CUL7 expression in LIHC, regardless of cancer stage, patient gender, age, or racial background. Furthermore, promoter methylation analysis indicated hypermethylation of the CUL7 promoter in LIHC samples compared to normal controls, implying potential epigenetic dysregulation of CUL7 in LIHC pathogenesis. Notably, differences in promoter methylation levels were observed across different cancer stages, patient genders, ages, and racial groups, highlighting the complex relationship between CUL7 promoter methylation and various clinical parameters in LIHC. Additionally, survival analysis demonstrated a significant association between CUL7 expression levels and patient overall survival, with high CUL7 expression correlating with shorter survival rates in LIHC patients. However, mutational analysis using the cBioPortal platform did not reveal significant mutations in CUL7 in LIHC samples. Overall, these findings shed light on the potential role of CUL7 as a biomarker and therapeutic target in LIHC management, emphasizing its clinical significance in prognostic assessment and personalized treatment strategies.
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Muhammad Ejaz
Govrnemnt FMF Graduate College, Gujranwala, Pakistan, Pakistan,
Sanobar Gull
Department of Biochemistry, Government College University Faisalabad, Pakistan,
Huma Umbreen
Department of Nutritional Sciences, Government College University Faisalabad, Pakistan
Farhana Noureen
Government Associate College for Women, Sargodha, Pakistan
Syeda Amber Hameed
Department of Zoology Microbiology Division, Emerson University Multan, Pakistan
Qudratullah Kalwar
Department of Theriogenology SBBUVAS, Sakrand , Pakistan,
Reema Bughio
Department Animal Breeding and Genetics SBBUVAS, Sakrand, Pakistan,
Muhammad Arif Rizwan
Institute of Continuing Education and Extension, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan,
Junaid Farooq
Institute of Biotechnology and Microbiology, Bacha Khan University Charsadda, Pakistan
Habibullah Janyaro
Department of Veterinary Surgery, SBBUVAS, Sakrand, Pakistan
I Made Dwi Mertha Adnyana
Department of Biology, Faculty of Technology and Science, Universitas Hindu Indonesia, Jl. Sangalangit, Tembau, Penatih, Denpasar city, 80236, Indonesia,
Department of Tropical Medicine, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, East Java, 60132 Indonesia
Associate Epidemiologist, Indonesian Society of Epidemiologists, Jl. Percetakan Negara No.29 23, RT.23/RW.7, Johar Baru, Kec. Johar Baru, Kota Jakarta Pusat, Daerah Khusus Ibukota Jakarta 10560, Indonesia