DECIPHERING THE ORCHESTRATED SYMPHONY: ANLN'S MULTIFACETED ROLE IN LIVER HEPATOCELLULAR CARCINOMA PATHOGENESIS AND PROGNOSIS
Main Article Content
Keywords
ANLN, LIHC, Biomarker, Prognosis
Abstract
The role of Anillin Actin Binding protein (ANLN) in Liver Hepatocellular Carcinoma (LIHC) is investigated through comprehensive expression and methylation analyses, genetic mutation inquiry, and prognostic assessment. Utilizing the UALAN database, ANLN expression is found significantly elevated in LIHC samples compared to normal controls, suggesting its regulatory involvement in LIHC proliferation. Further examination based on different parameters such as cancer stages, patient demographics, and promoter methylation levels reveals consistent overexpression of ANLN across diverse conditions, emphasizing its pivotal role in LIHC pathogenesis. Interestingly, promoter hypomethylation of ANLN is observed in LIHC samples compared to normal controls, indicating a negative correlation between ANLN expression and promoter methylation, with therapeutic implications. Genetic mutation analysis via cBioPortal identifies a minimal proportion of ANLN mutations in LIHC, predominantly amplifications and missense mutations, indicating their basal significance in ANLN dysregulation within LIHC. Prognostic assessment utilizing KM plotter demonstrates a significant correlation between ANLN overexpression and decreased overall survival rates in LIHC patients, suggesting ANLN's potential as a prognostic biomarker for disease progression and patient outcome prediction. Collectively, these findings underscore the crucial involvement of ANLN in LIHC progression and development, providing insights into its potential as a therapeutic target and prognostic indicator in the clinical management of LIHC. Further exploration of ANLN's molecular mechanisms and its interplay within the LIHC microenvironment may unveil novel avenues for targeted therapy and precision medicine approaches in combating this challenging disease.
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Hafeez Ullah
Department of Microbiology, Abasyn University, Peshawar, Pakistan
Sonia Tariq
Department of Pharmacy, Superior University, Lahore, Pakistan
Zainab lanjar
Department of Veterinary Microbiology, SBBUVAS Sakrand, Pakistan
Ishtiaq Hussain
Allama Iqbal Medical College & Jinnah Hospital, Lahore, Pakistan
Asim Shamim
Department of Pathobiology, Faculty of Veterinary and Animal Sciences, University of Poonch, Rawalakot Azad Kashmir, Pakistan
Noorahman Noori
Allama Iqbal Medical College & Jinnah Hospital, Lahore, Pakistan
Sadia Hakeem
National Hospital & Medical Centre, Lahore, Pakistan
Erum Bughio
Department of Poultry Production, FAP&T SBBUVAS, Sakrand, Pakistan
Muhammad Mohsen Rahimoon
Department of Animal Reproduction, SBBUVAS, Sakrand, Pakistan
Muhammad Arif Rizwan
Institute of Continuing Education and Extension, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Punjab, Pakistan
Habibullah Janyaro
Department of Veterinary Surgery SBBUVAS Sakrand, Shaheed Benazir Bhutto University of Veterinary and Animal Sciences Sakrand, Pakistan,