CLINICAL CHARACTERISTICS AND ANALYSIS OF HEMATOLOGICAL VARIATIONS IN BREAST CANCER PATIENTS FROM PUNJAB PROVINCE, PAKISTAN
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Keywords
Cancer, Breast cancer, Clinical, Hematology, Pakistan
Abstract
Introduction: Cancer is characterized by the uncontrolled proliferation of abnormal cells, capable of invading surrounding tissues. Breast cancer is very common in females, about 25%. The Complete Blood Count is a standard diagnostic assessment routinely ordered by physicians to assess various diseases.
Objectives: The purpose of this work was to investigate clinical characteristics with significant role of hematological parameters in breast cancer patients.
Materials and methods: Seventy cases were enrolled, with 15 subjects in the control group and an additional 25 women diagnosed with breast cancer serving as the case group. Hematological indices were studied by Sysmex KX-21N™automated analyzer tool.
Results: Among all patients, males comprised 3.33%, while females accounted for 96.67%.The mean and standard deviation of people with clinical details show age as 41.7± 6.67. All patients were diagnosed with Invasive Ductal Carcinoma. Various hematological parameters were examined. The mean and standard deviation of people for hematological indices among control was 3.45±4.22and breast cancer patients was 7.5±10.77. Hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, platelets count, and monocytes exhibited no statistical significance (p > 0.05), while others exhibited significance. The mean ± standard deviation of HCT, MCV, MCH, and MCHC among controls were 4.32 ± 5.25, 7.57 ± 9.28, 2.72 ± 3.33, and 0.89 ± 0.99, respectively. In contrast, among breast cancer patients, these values were 35.05 ± 5.92, 82.16 ± 9.02, 26.96 ± 3.58, and 32.6 ± 2.46, respectively.
Conclusion: In conclusion, a higher proportion of females were diagnosed with breast cancer, and all cases were identified as Invasive Ductal Carcinoma. Hematological profiles differed between the control and affected groups. Further studies are needed to thoroughly investigate hematological variations between these groups.
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Saba Munir
Department of Zoology, Faculty of Life sciences, University of Okara, Okara, Pakistan
Yasir Nawaz
Department of Zoology, Faculty of Life sciences, University of Okara, Okara, Pakistan
Fouzia Tanvir
Department of Zoology, Faculty of Life sciences, University of Okara, Okara, Pakistan
Asma Umar
Department of Pathology, Allama Iqbal Medical College, Lahore, Pakistan
Aqeela Nawaz
Department of Zoology, Faculty of Life sciences, University of Okara, Okara, Pakistan
Shumila Noreen
Department of Zoology, Faculty of Life sciences, University of Okara, Okara, Pakistan
Hafiza Fizzah Riaz
Department of Zoology, The Islamia University of Bahawalpur, Rahim Yar Khan campus, Pakistan
Salman Ahmad
Department of Zoology, Kohat University of Science and Technology, Pakistan
Huma Shaheen
Department of Zoology, Shaheed Benazir Bhutto Women University Peshawar, Pakistan
Alia Iqbal
Department of Zoology, Faculty of Life sciences, University of Okara, Okara, Pakistan