EFFECTS OF FOLIC ACID AND METHYLCOBALAMIN ADJUVANT THERAPY ON IMPROVEMENT OF CLINICAL SYMPTOMS AND BDNF LEVELS IN SCHIZOPHRENIA PATIENTS
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Keywords
Schizophrenia, Folic acid, Methylcobalamin, Risperidone, Clinical Symptoms, BDNF Serum, Adjuvant Therapy, Mental Health, Integrative Treatment, Cognitive Markers.
Abstract
Schizophrenia, characterized by delusions, hallucinations, and cognitive impairments, poses significant challenges for individuals and society. This study investigates the effects of adjuvant therapy with folic acid and methylcobalamin on clinical symptoms and brain-derived neurotrophic factor (BDNF) levels in schizophrenia patients receiving risperidone. A total of 46 subjects participated in 8-week experimental analysis, with the treatment group receiving adjuvant therapy alongside risperidone at Department of Psychiatry, Jinnah Post Graduate Medical Centre Karachi. Positive and significant improvements in clinical symptoms (63.33%) and BDNF levels were observed in the treatment group compared to the control group. The study contributes valuable insights into the potential benefits of adjuvant therapy for schizophrenia treatment.
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Dr Kulsoom Lashari
FCPS, Consultant Psychiatrist, Jinnah Post Graduate Medical Center Karachi
Dr Muhammad Ilyas
Assistant Professor Psychiatry at Balochistan Institute of Psychiatry and Behavioral Sciences Quetta
Dr Raz Muhammad Bazai
Professor of Neurosurgery, BMCH Quetta
Dr Manisha Kumari
Post Graduate Trainee, Department of Psychiatry, Jinnah Post Graduate Medical Centre Karachi
Sandya Bai
MBBS, Ghulam Mohammad Mahar Medical College Sukkur (SMBBU Larkana)
Sangeet
FCPS Post Graduate Resident at Jinnah Post Graduate Medical Center, Karachi