CLINICOPATHOLOGICAL EVALUATION OF ENDOMETRIAL CURETTAGE SPECIMENS FROM A TERTIARY CARE CENTRE

Abstract

Introduction: Endometrial sampling stands as the benchmark for diagnosing abnormal uterine bleeding (AUB), chiefly aimed at uncovering its origins, particularly to ascertain the presence of cancerous or precancerous conditions. AUB ranks as the most frequent complaint encountered in gynecological clinics. This paper delves into an analysis of endometrial curettage specimens, focusing on their clinicopathological characteristics, based on a study encompassing numerous cases.

Objectives: The primary goal of this investigation was to conduct a clinicopathological assessment of a substantial collection of endometrial curettage specimens within a tertiary healthcare setting.

Methods: The study meticulously examined 400 endometrial curettage specimens, applying Hematoxylin and Eosin (H&E) staining as the fundamental technique. Additional special stains and immunohistochemistry (IHC) were utilized as necessary. A thorough clinicopathological comparison was performed for each case, with findings benchmarked against previous research.

Results: The age range of subjects in this study spanned from 18 to 70 years, with a predominant age bracket of 31-40 years. The most frequent observations included cyclical endometrial changes, followed by various endometrial pathologies and trophoblastic diseases.

Conclusion: The endometrial biopsy emerges as a crucial diagnostic instrument for gynecological disorders. Recognizing the histopathological patterns of the endometrium associated with AUB across different age groups is vital for patient management. Bleeding post-menopause should be treated with suspicion for malignancy until proven otherwise.