COMPARATIVE EFFICACY OF ALOE VERA (ALOBARBADENSIS) AND TURMERIC (CURCUMA LONGA) ON BURN WOUND HEALING IN RABBIT MODEL

Abstract

Severe burns represent some of the most distressing and physically incapacitating injuries, impacting nearly all bodily systems and resulting in substantial morbidity and mortality rates. This study investigates the efficacy of Aloe vera and turmeric, both individually and in combination, on burn wounds in a rabbit model. Forty rabbits were randomly allocated into four groups (A, B, C, and D), each subjected to topical treatments. Wounds were induced using sulfuric acid. Group A received Aloe vera, Group B received turmeric, Group C received a combination of Aloe vera and turmeric, while Group D served as the control and was treated with silver sulfadiazine. The impact of treatments was assessed in terms of wound contraction, tensile strength, healing duration, and histopathological analysis. Group C exhibited accelerated wound contraction, reaching maximum contraction by day 10, and demonstrated the shortest healing duration among all groups i.e. 22.80 ± 0. 490.Notably, the combination therapy of Aloe vera and turmeric outperformed individual treatments, showcasing synergistic effects. Histopathological examination revealed enhanced granulation and epithelial tissue growth in Group C, corroborating the observed expedited healing. These findings highlight the potential of Aloe vera and turmeric as cost-effective, easily accessible topical agents for wound management, owing to their synergistic action and stimulation of tissue regeneration