COMPARATIVE STUDY OF BIOCHEMICAL AND ANTIOXIDATIVE STATUS IN PROSTATE CANCER PATIENTS RECEIVING DIFFERENT THERAPIES
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Keywords
Prostate, Cancer, Patients, BMI, Chemotherapy, Oxidative, Stress
Abstract
Introduction: The management of prostate cancer involves a spectrum of treatment modalities, ranging from surgery and radiation therapy to hormonal manipulation and chemotherapy.
Objectives: The basic aim of the study is to find the comparative study of biochemical and antioxidative status in prostate cancer patients receiving different therapies.
Material and methods: This comparative study enrolled a total of 240 participants diagnosed with prostate cancer at Shalamar Hospital in Lahore, Pakistan, between the duration of 2022 to 2023. Patients were recruited following institutional ethical approval and informed consent. Baseline data including demographic information, tumor staging, and treatment details were recorded for each participant. Blood samples were collected pre-treatment and at specific intervals post-treatment to assess biochemical parameters such as lipid profiles, glucose levels, liver and kidney function markers, and inflammatory indicators.
Results: The study revealed treatment-specific alterations in biochemical profiles, showcasing distinct metabolic shifts among groups. Surgery demonstrated modest changes in serum cholesterol, while pharmacological intervention correlated with notable elevations in serum cholesterol, glucose, and ALT levels. Oxidative stress markers displayed marginal changes across groups, implying a mild induction of oxidative stress post-treatment. BMI and serum albumin remained relatively stable across treatments.
Conclusion: It is concluded that distinct therapeutic interventions in prostate cancer elicit diverse metabolic shifts, as evidenced by treatment-specific alterations in biochemical profiles. While oxidative stress markers showed marginal changes, stable clinical parameters suggest relative consistency in BMI and serum albumin across treatments.
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Shahid Ali
Senior Registrar Urology Department, Shalamar Hospital, Lahore - Pakistan
Shazia Siddique
Biochemistry Department, Sahiwal Mediation College, Sahiwal - Pakistan
Maleha Asim
Associate Professor Biochemistry Department, Riphah International University, Islamabad - Pakistan
Muhammad Murtaza
Department of Urology and Renal Transplantation, Allied Hospital, Faisalabad Medical University (FMU), Faisalabad – Pakistan
Saim Sattar
Associate Professor of Medicine, Watim Dental and Medical College (WDMC), Rawalpindi - Pakistan