ASSESSMENT OF PERIODONTAL STATUS, C-REACTIVE PROTEIN AND FIBRINOGEN LEVELS IN PATIENTS WITH PERIODONTITIS AND MYOCARDIAL INFARCTION
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Keywords
myocardial infarction, c-reactive protein, fibrinogen, periodontitis, inflammation
Abstract
The aim of the study was to assess and compare the periodontal status, C-reactive protein and plasma fibrinogen levels, in periodontitis patients with and without myocardial infarction in association with the other confounding factors.
Materials and Methods: The study comprised of 86 subjects aged 30 years and above divided into 2 groups: MI+P: Patients with Myocardial Infarction with periodontitis and P: periodontitis. Medical history was taken and all the confounding factors were recorded including the history of hypertension and diabetes. All the subjects underwent assessment and comparison of periodontal status such as Plaque index (PI), Periodontal index (Pi), Clinical attachment level (CAL) and Probing Pocket depth (PPD) along with the estimation of C-reactive protein and fibrinogen levels.
Results: The periodontal parameters were found to be increased in patients with myocardial infarction and periodontitis with more possibility of the presence of the various confounding factors associated with MI+P group. C- reactive protein and fibrinogen levels were also found to be elevated in these patients with significant p-value. Plaque index and fibrinogen level showed a significant odds ratio in comparison with the other confounding variables.
Conclusion: Our study confirms an increase in the severity of periodontal status in patients with myocardial infarction with periodontitis. Increased C- reactive protein and elevated fibrinogen levels were also observed to be increased indicating them as potential inflammatory markers for myocardial infarction (MI). In future, more prospective studies with periodontal intervention are needed to further authenticate the role of periodontitis with respect to the other confounding factors considering C- reactive protein and fibrinogen levels as markers of inflammation.
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