PREDICTORS OF MORTALITY IN VERY LOW BIRTH WEIGHT AND EXTREMELY LOW BIRTH WEIGHT NEONATES IN JAIPUR
Main Article Content
Keywords
Mortality, Very Low Birth Weight Babies (VLBW), Extremely Low Birth Weight Babies (ELBW), Neonates
Abstract
In low- and middle-income countries, the majority of neonatal deaths occur without a clear cause of
death (i.e., pre-maturity). Due to the paucity of data for Neonatal mortality & associated factors in
our geographical area, this study has been planned to determine the predictors of mortality in very
low birth weight babies (VLBW) and extremely low birth weight babies (ELBW).
Materials & Methods: This observational descriptive study was conducted in the Neonatal ICU,
National Institute of Medical Sciences and Research, Jaipur, Rajasthan. All neonates with very low
birth weight (VLBW) & extremely low birth weight (ELBW) admitted to NICU were included.
Univariate analysis and logistic regression analysis were done to determine the predictors of shortterm outcomes & mortality.
Results: 174 neonates were studied. 104 (59.77%) were male children and 70 (40.23%) were female.
Mortality was seen among 6.15% VLBW babies & 45.5% ELBW babies. Febrile illness during
pregnancy, Birth weight, Gestational age, need for resuscitation after birth, elevated CRP, Low RBS,
and SAS Score less than 7 were found statistically significant and were independent predictors of
mortality.
Conclusions: The incidence of early neonatal mortality in low-birth-weight newborns and incredibly
higher in Extremely low weight. There is an urgent need for dedicated special care for ELBW &
VLBW neonates by primary health care providers and other stakeholders on the first day of
admission.
References
2. UNICEF, WHO, The World Bank, United Nations Population Division. Levels and Trends in Child Mortality: Report 2019 Estimates Developed by the UN Inter-agency Group for Child Mortality Estimation. UNICEF .2019.
3. Batieha A, Khader Y, Berdzuli N, Chua-Oon C, Badran E, Al-Sheyab N, et al. Level, causes and risk factors of neonatal mortality, in jordan: results of a national prospective study. Matern Child Health J. 2016; 20:1061– 71.
4. Goldenberg RL, Muhe L, Saleem S, Dhaded S, Goudar SS, Patterson J, et al. Criteria for assigning cause of death for stillbirths and neonatal deaths in research studies in low-middle income countries. J Matern Fetal Neonatal Med. 2019; 32:1915–23.
5. Ministry of Health and Family Welfare, Government of India. National Health Policy 2017. New Delhi. 2017. https://mohfw.gov. in/sites/default/files/9147562941489753121.pdf (accessed Sept 10, 2021).
6. Ye J, Zhang J, Mikolajczyk R, Torloni M, Gülmezoglu A, Betran A. Association between rates of caesarean section and maternal and neonatal mortality in the 21st century: a worldwide population-based ecological study with longitudinal data. BJOG. 2016; 123:745–53
7. Gibbons L, Belizan JM, Lauer JA, Betran AP, Merialdi M, Althabe F. Inequities in the use of cesarean section deliveries in the world. Am J Obstet Gynecol. 2012; 206:331.e1–19.
8. Ye J, Betrán AP, Guerrero Vela M, Souza JP, Zhang J. Searching for the optimal rate of medically necessary cesarean delivery. Birth. 2014; 41:237– 44.
9. Yasmin S, Osrin D, Paul E, Costello A. Neonatal mortality of low-birth-weight infants in Bangladesh. Bull World Health Organ. 2001;79(7):608–14.
10. Blencowe H, Kerac M, Molyneux E. Safety, effectiveness and barriers to follow-up using an ‘early discharge’ kangaroo care policy in a resource poor setting. J Trop Pediatr. 2009;55(4):244–8.
11. Vazirinejad R, Masoodpour N, Puyanfar A. Survival rate of low and very low birth weight neonates in an Iranian community. Iran J Public Health. 2012;41(2):87–93
12. Abdallah Y, Namiiro F, Nankunda J, Mugalu J, Vaucher Y. Mortality among very low birth weight infants after hospital discharge in a low resource setting. BMC Pediatr. 2018;18(239).
13. UNICEF. Uganda Maternal and Newborn Health Disparities [Internet]. 2015. Available from: https://data.unicef.org/wp349content/uploads/country_profiles/Uganda/countryprofile_UGA.pdf
14. Lawn JE, Blencowe H, Oza S, You D, Lee AC, Waiswa P, et 351 al. Every Newborn: progress, priorities, and potential beyond survival. Lancet. 2014 Jul 12;384(9938):189–205.
15. Leal YA, Álvarez-Nemegyei J, Velázquez JR, Rosado-Quiab U, Diego-Rodríguez N, Paz-Baeza E, et al. Risk factors and prognosis for neonatal sepsis in southeastern Mexico: analysis of a four-year historic cohort follow-up. BMC Pregnancy Childbirth. 2012;12:48.
16. Adegoke S, Bankole K, Olugbemiga A, Tinuade O. Intraventricular hemorrhage in newborns weighing <1500 g: Epidemiology and short-term clinical outcome in a resource-poor setting. Ann Trop Med Public Heal. 2014;7(1):48.
17. Adatara P, Afaya A, Salia SM, Afaya RA, Kuug AK, Agbinku E, et al. Risk Factors for Neonatal Sepsis: A Retrospective Case-Control Study among Neonates Who Were Delivered by Caesarean Section at the Trauma and Specialist Hospital, Winneba, Ghana. Biomed Res Int. 2018;2018.
18. Abdullah A, Hort K, Butu Y, Simpson L. Risk factors associated with neonatal deaths: A matched case-control study in Indonesia. Glob Health Action. 2016;9(1). 27. Ehrenstein V. Clinical Epidemiology Association of Apgar scores with death and neurologic disability. Clin Epidemiol. 2009;1:1–45.
19. Cnattingius S, Johansson S, Razaz N. Apgar Score and Risk 378 of Neonatal Death among Preterm Infants. N Engl J Med. 2020;383(1):49–57.