DEVELOPMENT AND EVALUATION OF SESAMOL LOADED LINUM USITATISSIMUM SEED MUCILAGE BASED MICROSPHERES
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Keywords
Sesamol, Linum usitatissimum, Natural Mucilage, Microspheres, Antihyperlipidemic
Abstract
The mucilages are polysaccharide obtained from various seeds. Thus, present study is started with aim to formulate Linum usitatissimum seed mucilage based microspheres of sesamol. The drug loaded microspheres were formulated using ionic gelation method and evaluated for physicochemical properties. The mucilage showed acceptable colour, odour and taste. The microspheres showed good swelling ability, mucoadhesive potential and sustained drug release. Thus, linseed mucilage could be promising alternative for fabrication of gastroretentive drug delivery system.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Subhranshu Panda
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India, 302017.
Umesh Jirole
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India, 302017
Santosh Jadhav
Department of Pharmaceutical Chemistry, SVPM'S College of Pharmacy, Malegaon, Maharashtra, India, 413115.
Dhanashree Jirole
Ashokrao Mane Institute of Pharmaceutical Sciences and Research, Save Tal- Shahuwadi, Dist- Kolhapur, 416213
Vivek Kulkarni
Department of Pharmaceutical chemistry, Indira Institute of Pharmacy, Sadavali, Maharashtra, India, 415804.