SYNTHESIS OF PALMITOYL CHLORIDE MANNOSE CONJUGATE AS TARGETING LIGAND FOR LIVER TARGETING OF CAPACITABINE LOADED LIPOSOMES
Main Article Content
Keywords
Capacitabine, Liposomes, Palmitoyl chloride mannose conjugate, hepatocyte targeting
Abstract
Nanotechnology mediated drug delivery is utilize nowadays for effective drug delivery at desired cell target. Many scientific investigators have utilized nanocarrier mediated drug delivery of antitumor drug for active targeting of encapsulated drug at desired target cells. Capacitabine is approved anticancer drug especially use for management of breast and colon cancer. Various conventional drug delivery systems of capacitabine are available for clinical use. However, limited oral bioavailability is major hurdle associated with conventional delivery of capacitabine. Thus, present study has started with aim to synthesize palmitoyl chloride mannose conjugate for hepatocyte targeting of capacitabine loaded liposomes
References
2. González-ortega, R., Luka, Š., Skrt, M., Daniela, C., Mattia, D., Pittia, P., 2020. Liposomal Encapsulation of Oleuropein and an Olive Leaf Extract : Molecular Interactions , Antioxidant Effects and Applications in Model Food Systems. Food Biophys.
https://doi.org/https://doi.org/10.1007/s11483-020-09650-y
3. Gupta, M.K., Sansare, V., Shrivastava, B., Jadhav, S., 2021. Design , fabrication and characterization of sesamol loaded polymeric nanoparticles : In vivo hepatoprotective potential in Wistar rats. Nanomedicine Res. J. 6, 296–303. https://doi.org/10.22034/nmrj.2021.03.010
4. Gupta, M.K., Sansare, V., Shrivastava, B., Jadhav, S., Gurav, P., 2022. Fabrication and evaluation of mannose decorated curcumin loaded nanostructured lipid carriers for hepatocyte targeting: In vivo hepatoprotective activity in Wistar rats. Curr. Res. Pharmacol. Drug Discov. https://doi.org/https://doi.org/10.1016/j.crphar.2022.100083
5. Marwah, M., Narain Srivastava, P., Mishra, S., Nagarsenker, M., 2020. Functionally engineered ‘hepato-liposomes’: Combating liver-stage malaria in a single prophylactic dose. Int. J. Pharm. 587, 119710. https://doi.org/10.1016/j.ijpharm.2020.119710
6. Nazari-Vanani, R., Karimian, K., Azarpira, N., Heli, H., 2019. Capecitabine-loaded nanoniosomes and evaluation of anticancer efficacy. Artif. Cells, Nanomedicine Biotechnol. 47, 420–426. https://doi.org/10.1080/21691401.2018.1559179
7. Pranatharthiharan, S., Patel, M.D., Malshe, V.C., Gorakshakar, A., Madkaikar, M., Ghosh, K., Padma, V., Pranatharthiharan, S., Patel, M.D., Malshe, V.C., Pujari, V., Gorakshakar, A., 2017. Asialoglycoprotein receptor targeted delivery of doxorubicin nanoparticles for hepatocellular carcinoma. Drug Deliv. 24, 20–29. https://doi.org/10.1080/10717544.2016.1225856
8. Sansare, V., Gupta, M.K., Shrivastava, B., Jadhav, S., Gurav, P., 2021. Comprehensive review on use of phospholipid based vesicles for phytoactive delivery. J. Liposome Res. https://doi.org/10.1080/08982104.2021.1968430
9. Sansare, V., Warrier, D., Shinde, U., 2020. Cellular trafficking of nanocarriers in alveolar macrophages for effective management of pulmonary tuberculosis. J. Tuberc. 3, 1016.
10. Shah, S.M., Pathak, P.O., Jain, A.S., Barhate, C.R., Nagarsenker, M.S., 2013. Synthesis , characterization , and in vitro evaluation of palmitoylated arabinogalactan with potential for liver targeting. Carbohydr. Res. 367, 41–47. https://doi.org/10.1016/j.carres.2012.11.025
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Subhranshu Panda
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India, 302017
Prashant Mane
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India, 302017.
B. N. Poul
Maharashtra College of Pharmacy Nilanga, Latur, Maharashtra, India, 413521